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| 1 | Research trends and development status of TCM network pharmacology: a bibliometric study显示文摘Objective: To analyze the research status, development context and trend of traditional Chinese medicine (TCM) network pharmacology from birth to the present. Methods: In this study, bibliographic data and references of articles on TCM network pharmacology were collected from Web of Science Core Collection (WoSCC), and software including CiteSpace, VOSviewer and Microsoft Excel were applied for the bibliometric analysis of periodicals and the quantity of literature, and for the construction and analysis of the co-occurrence network of countries, journals, research institutes and authors, clusters of co-cited references, and time distribution network of keywords. Results: 249 articles were included in this study. The time span was from 2011 to 2018, and the annual volume of publications showed an increasing trend year by year. The 77 journals contain relevant literature, and the average impact factor of the journal is 3.215. Chinese Journal of Natural Medicines, Scientific Reports, PLoS One have high influence in the field of TCM network pharmacology. Universities and research institutes including China Academy of Chinese Medical Science and Northwest Agriculture & Forestry University are the major forces in this field. Wang Yonghua and Li Shao are authors with high influence in this field, with a considerable number of relevant documents and citations. According to the clustering results of co-cited references, research topics can be classified into 13 development contexts such as “compound danshen formula”,“computational tool”, and “new multi-compound drug discovery”. Hotspots of TCM network pharmacology include “drug discovery”,“mechanism” and “cardiovascular disease”, and relevant research methods and research contents including drugs and diseases tend to be constantly enriched. Conclusion: This study comprehensively demonstrates the research status, development context and trends of TCM network pharmacology, and provides a scientific reference for TCM network pharmacology researchers. | Yu-Zhi Shang Qing-Huai Zhang Qiu-Xia Chen Xiu-Song Tang Yu-Zhou Pang Gang Fang | 2019 | Drug Combination Therapy2019，1，3： | 2 |
| 2 | A network pharmacological study on the potential mechanism of Yinchenhao Decoction in treatment of chronic hepatitis B显示文摘Background: Yinchenhao Decoction (YCHD), an ancient Chinese herbal medicinal compound prescribe for the treatment of jaundice, which long-term clinical experience and randomized trials have shown is effective against chronic hepatitis B (CHB). However, its mechanism remains unknown. With the gradual separation of pharmacodynamic components in YCHD and the development of computer virtual technology, network pharmacology provides an opportunity. Our study is to explore the underlying mechanism of YCHD for the treatment of CHB. Methods: The active compounds of YCHD were screened from TCMSP database, whose targets were predicted based on the ligands structures and the targets of CHB was selected from the TTD, DisGeNET, and Drugbank databases to obtain the potential targets of YCHD for CHB treating. Cytoscape 3.6.1 was applied for network analysis to identify key targets, and gene enrichment of the targets shared by both YCHD and CHB was performed by DAVID database. The virtual verification of binding abilities between the target protein and the small molecule was finally performed by the Sytems Dock platform. Results: The potentially important targets associated with CHB corresponding to 33 compound components from YCHD included ESR1, CYP1A2, PTGS2, CYP1A1, ABCG2, MMP9. Besides, enriched were the related 8 KEGG pathways (P<0.05) such as ABC transporters, Bile secretion, TNF signaling pathway. Conclusions: This study used network pharmacology method to reveal the characteristics,“multi-component and multi-target and multi-pathway”, of YCHD on CHB treatment, providing thoughts for further research. | Jin-Yu Zhang Xian-Fa Cai | 2019 | Drug Combination Therapy2019，1，3： | 2 |
| 3 | Spin models on bipartite distance-regular graphs 显示文摘 | NOMURA K | 1995 | J Combin Theory (Ser B)1995，64，： | 2 |
| 4 | Decomposing Complete Graphs into Isomorphic Subgraphs with Six Vertices and Seven Edges 显示文摘 | TIAN Zi-hong DU Yan-ke KANG Qing-de | 2006 | Ars Combin2006，81，： | 1 |
| 5 | The 2-pebbling property and a conjecture of Graham's显示文摘 | Foster J A | 2000 | Graphs Combin2000，16，2： | 1 |
| 6 | Upper Bounds for the SPOT5 Daily Photograph Scheduling Problem 显示文摘 | Michel Vasquez | 2003 | Journal of Combinational Optimization2003，7，3： | 1 |
| 7 | On large sets of resolvable and almost resolvable oriented triple systems显示文摘 | KANG Oing-de LEI Jian-guo | 1996 | J Combin Designs1996，4，2： | 1 |
| 8 | Maximum permanents of matrices of zeros and ones显示文摘 | Brualdi R A Coldwasser J L Michael S T | 1988 | J Combin Theory( Ser A)1988，，49： | 1 |
| 9 | Almost every K4 -homeomorph is chromatically unique 显示文摘 | LI W M | 1987 | Ars Combin1987，23，： | 1 |
| 10 | Flows in infinite graphs 显示文摘 | Folkman J Fulkerson D R | 1970 | J Combin Theory1970，，8： | 1 |
| 11 | Multicolored hamilton cycles显示文摘 | ALBERT M FRIEZE A REED B | 1995 | Electronic J Combin1995，2，： | 1 |
| 12 | On the powers of tournament matrices 显示文摘 | Moon J W Pullman N J | 1967 | J Combin Theory1967，，3： | 1 |
| 13 | Equitable coloring of trees显示文摘 | Chen B L Lih K W | 1994 | J Combin Theory Ser B1994，61，1： | 1 |
| 14 | The Search for Chromatically Unique Graphs显示文摘 | KOH K M TEO K L | 1990 | Graph Combin1990，6，： | 1 |
| 15 | Jianpi Bushen Recipe affects epithelial-mesenchymal transition in hepatocellular carcinoma through TGF-β and Twist显示文摘Backgroud:To explore the effects of Jianpi Bushen Recipe on the epithelial-mesenchymal transition(EMT)of nude mice with transplanted human liver cancer SK-HEP-1 cells.Methods:To establish models with transplanted liver cancer cells,nude mice were divided randomly into three groups:blank group,traditional Chinese medicine(TCM)group and control group.They were given normal saline,Jianpi Bushen Recipe and solafeni through administration by gavage for four weeks.The expression of TGF-β and twist mRNA were detected by real-time PCR.The expression of E-cadherin was detected by Western blot.Results:Compared with the blank group,the expression of transforming growth factor-P(TGF-β)mRNA and twist mRNA in the TCM group and the control group decreased significantly(P<0.05).There was no significant difference between the two groups(P>0.05).The expression of E-cadherin protein in TCM group and control group increased significantly(P<0.01).There was no significant difference between the two groups(P>0.05).Conclusion:Jianpi Bushen Recipe can inhibit the EMT of liver cancer SK-HEP-1 cells in vivo by down-regulating the expression of TGF-β/twist signaling and indirectly up-regulating E-cadherin expression in transplanted liver cancer tissue,indicating the potential of Jianpi Bushen Recipe to inhibit invasion and metastasis of liver cancer. | Hong-Jie Liu You—Ying Lai Zhi-Fen Han Jian-Jie Chen Xin-Wen Ma | 2020 | Drug Combination Therapy2020，2，1： | 1 |
| 16 | The book thickness of a graph显示文摘 | Bemhart F R Kainen P C | 1979 | Combin Theory Ser B1979，27，3： | 1 |
| 17 | Edge coloring of embedded graphs with large girth显示文摘 | LI X LUO R | 2003 | Graphs Combin2003，19，3： | 1 |
| 18 | Constructions of optimal variable-weight optical orthogonal codes显示文摘 | ZHAO H WU D FAN P | 2010 | J Combin Des2010，18，： | 1 |
| 19 | Adam's conjecture is true in the square-free case显示文摘 | MUZYCHUK M | 1995 | J Combin Theory:A1995，72，： | 1 |
| 20 | A Fan type condition for heavy cycles in weighted graphs显示文摘 | Zhang Shenggui Broersma H J Li Xueliang | 2002 | Graphs Combin2002，18，： | 1 |
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