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| 1 | Residential environment index system and evaluation model established by subjective and objective methods显示文摘In this research, the residential environment index system and evaluation model were established by means of subjective and objective methods. The methodology for establishing the evaluation system for residential environment was first analyzed; then the subjective evaluation data-base was established by questionnaire survey; and at the same time, the objective evaluation data-base was constructed by Geographic Information System (GIS); and then the related equation system between subjective and objective system was developed by multiple regression analysis. This research could benefit evaluation of the residential environment quality for various purposes, and also provide important rudimentary data-base for the development and improvement of residential environment for officials. Furthermore, the index system and evaluation model established in this research could construct a strong relation between subjective evaluation and objective data; and thus could provide a comprehensive, efficient and effective methodology for the evaluation of residential environment. | 葛坚 HOKAOKazunori | 2004 | Journal of Zhejiang University Science2004，5，9： | 30 |
| 2 | Effects of atorvastatin on vascular remodeling in spontaneously hypertensive rats显示文摘Objective: To investigate the structural changes of aorta, and evaluate the effects of atorvastatinon the remodeling of thoracic aorta in spontaneously hypertensive rats(SHR) . Methods : Twelve eight-week-old SHR were randomized into atorvastatin treated group( ATV group, n = 6) and distilled water group( DW group, n = 6) ; Wistar-Kyoto rats(WKY) were used as normal controls. Atorvastatin was administered to ATV group for 10 weeks by gavage in mixture with distilled water( 1ml) ; the latter two groups were given the same amount of distilled water by gavage for 10 weeks. Systolic blood pressure of caudal artery was examined before and after treatment, and serum concentrations of total cholesterol, triglycerides and HDL-C were measured.Wall thickness, media thickness, medial cross-sectional area and lumen diameter of thoracic aorta were assessed with computed video processing. Results: Systolic blood pressure in ATV group was markedly lower than that in DW group( P < 0.01). Compared with DW group and WKY group, serum concentrations of total cholesterol, triglycerides and HDL-C in ATV group were significantly lower( P < 0.01, P < 0.05). Wall thickness, media thickness, and medial cross-sectional area to lumen ratio in DW group were significantly higher than those in WKY group and ATV group( P < 0.01, P < 0.05), but no such difference was found between WKY group and ATV group( P > 0.05 ). Conclusion : Vascular structural changes of aorta are due to the alteration of the vessel wall in early stage of SHR. Atorvastatin can markedly improve vascular remodeling. | 葛长江 胡申江 武垚森 陈乃云 | 2003 | Journal of Zhejiang University Science2003，4，5： | 25 |
| 3 | Experimental study on micro-electrolysis technology for pharmaceutical wastewater treatment显示文摘Experiments were conducted to study the role of micro-electrolysis in removng chromaticity and COD and improving the biodegradability of pharmaceutical wastewater.The results showed that the use of micro-electrolysis technology could remove more than 90% of chromaticity and more than 50% of COD and greatly improved the biodegradability of phamaceutical wastewater.Lower initial pH could be advantageous to the removal of chromaticity .A retention time of 30 minutes was recommended for the process design of micro-electrolysis. | 金一中 张月锋 李伟 | 2002 | Journal of Zhejiang University Science2002，3，4： | 24 |
| 4 | Numerical investigation of cavitating flow behind the cone of a poppet valve in water hydraulic system显示文摘Computational Fluid Dynarmics(CFD) simulations of cavitating flow throuth water hydraulic poppet valves were performed using advanced RNG κ-epsilon turbulence model. The flow was turbulent, incom-pressible and unsteady, for Reynolds nurnbers greater than 43 000.The working fluid was water, and the structure of the valve was simplified as a two dimensionl axisynmmetric gecomtrical model. Flow Field vlsual-ization was numerically achieved. The effects of inlet velocity, outlet pressure, opening size as wall as popet angle on cavitation intensity in the poppet valve were numerically investigated. Experimentall flow visualization was coonducted to capture cavitation images near the orifice in the poppet valve with 30° poppet angle using high speed video camera.The binary cavitafing flow field distrilxrdon obtalned frcra digital processing of the original cavitation image showed a gtxxt agreement with the ntmaerieal | 高红 傅新 杨华勇 TSUKIJITetsuhiro | 2002 | Journal of Zhejiang University Science2002，3，4： | 24 |
| 5 | Verifiable threshold signature schemes against conspiracy attack显示文摘In this study, the author has designed new verifiable (t, n) threshold untraceable signature schemes. The proposed schemes have the following properties: ( 1 ) Verification: The shadows of the secret distributed by the trusted center can be verified by all of the participants; (2) Security: Even if the number of the dishonest member is over the value of the threshold, they cannot get the system secret parameters , such as the group secret key, and forge other member's individual signature; (3) Efficient verification: The verifier can verify the group signature easily and the verification time of the group signature is equivalent to that of an individual signature; (4) Untraceability: The signers of the group signature cannot be traced. | 甘元驹 | 2004 | Journal of Zhejiang University Science2004，5，1： | 21 |
| 6 | An adaptive ant colony system algorithm for continuous-space optimization problems显示文摘Ant colony algorithms comprise a novel category of evolutionary computation methods for optimization problems, especially for sequencing-type combinatorial optimization problems. An adaptive ant colony algorithm is proposed in this paper to tackle continuous-space optimization problems, using a new objective-function-based heuristic pheromone assignment approach for pheromone update to filtrate solution candidates.Global optimal solutions can be reached more rapidly by self-adjusting the path searching behaviors of the ants according to objective values. The performance of the proposed algorithm is compared with a basic ant colony algorithm and a Square Quadratic Programming approach in solving two benchmark problems with multiple extremes. The results indicated that the efficiency and reliability of the proposed algorithm were greatly improved. | 李艳君 吴铁军 | 2003 | Journal of Zhejiang University Science2003，4，1： | 20 |
| 7 | Intrusion detection using rough set classification显示文摘Recently machine learning-based intrusion detection approaches have been subjected to extensive researches because they can detect both misuse and anomaly. In this paper, rough set classification (RSC), a modern learning algorithm, is used to rank the features extracted for detecting intrusions and generate intrusion detection models. Feature ranking is a very critical step when building the model. RSC performs feature ranking before generating rules, and converts the feature ranking to minimal hitting set problem addressed by using genetic algorithm (GA). This is done in classical approaches using Support Vector Machine (SVM) by executing many iterations, each of which removes one useless feature. Compared with those methods, our method can avoid many iterations. In addition, a hybrid genetic algorithm is proposed to increase the convergence speed and decrease the training time of RSC. The models generated by RSC take the form of'IF-THEN' rules, which have the advantage of explication. Tests and comparison of RSC with SVM on DARPA benchmark data showed that for Probe and DoS attacks both RSC and SVM yielded highly accurate results (greater than 99% accuracy on testing set). | 张连华 张冠华 郁郎 张洁 白英彩 | 2004 | Journal of Zhejiang University Science2004，5，9： | 16 |
| 8 | MRS study on lentiform nucleus in idiopathic Parkinson‘s disease with unilateral symptoms显示文摘Objective: To investigate changes in magnetic resonance spectroscopy (MRS) of lentiform nucleus during the early stage of Parkinson's disease. Methods: Twenty-five patients with idiopathic Parkinson disease with unilateral symptoms (IPDUS) and 25 healthy volunteers were enrolled in this study. MRS of the lentiform nucleus in each patient was taken and then concentrations ofN-acetylaspartate (NAA), Creatine (Cr) and Choline (Cho) were calculated. Results: Compared to that in the control, NAA/(Cho+Cr) was significantly lower in the lentiform nucleus contralateral to symptoms and even that in the ipsilateral side in IPDUS patients (all P<0.05); while there was no difference between the two sides in the healthy volunteer (P>0.05). The ratio of NAA/(Cho+Cr) ipsilateral to the sympatomatic side of the patient was also lower than that of the control (P<0.05). Conclusions: there might be some changes with MRS on the lentiform nucleus during the early stage of idiopathic Parkinson's disease with unilateral symptom. MRS may be one of the reliable methods for early or even sub-clinical diagnosis. | 郑旭宁 朱雄超 阮凌翔 张玲菊 袁敏 商德胜 柳扬 | 2004 | Journal of Zhejiang University Science2004，5，2： | 16 |
| 9 | Production of bacterial blight resistant lines from somatic hybridization between Oryza sativa L. and Oryza meyeriana L.显示文摘Novel bacterial blight (BB) resistance gene(s) for rice was (were) introduced into a cultivated japonica rice variety Oryza sativa (cv. 8411), via somatic hybridization using the wild rice Oryza meyeriana as the donor of the resistance gene(s). Twenty-nine progenies of somatically hybridized plants were obtained. Seven somatically hybridized plants and their parents were used for AFLP (amplified fragment length polymorphism) analysis using 8 primer pairs. Results confirmed that these plants were somatic hybrids containing the characteristic bands of both parents. The morphology of the regenerated rice showed characters of both O.sativa and O.meyeriana. Two somatic hybrids showed highest BB resistance and the other 8 plants showed moderate resistance. The new germplasms with highest resistance have been used in the rice breeding program for the improvement of bacterial blight resistance. | 严成其 钱凯先 薛刚平 吴忠长 陈跃磊 颜秋生 张雪琴 吴平 | 2004 | Journal of Zhejiang University Science2004，5，10： | 15 |
| 10 | EAG and behavioral responses of Helicoverpa armigera males to volatiles from poplar leaves and their combinations with sex pheromone显示文摘Electroantennogram (EAG) evaluation of selected compounds from wilted leaves of black poplar, Populus nigra, showed that phenyl acetaldehyde, methyl salicylate, (E)-2-hexenal elicited strong responses from male antennae of Helicoverpa armigera. When mixed with sex pheromone (Ph), some volatiles, e.g. phenyl acetaldehyde, benzyl alcohol, phenylethanol, methylsalicylate, linalool, benzaldehyde, (Z)-3-hexenol, (Z)-3-hexenylacetate, (Z)-6-nonenol, cineole, (E)-2-hexenal, and geraniol elicited stronger responses from male antennae than Ph alone. Wind tunnel bioassay demonstrated that various volatiles could either enhance or inhibit the effect of synthetic sex pheromone. (E)-2-hexenal, (Z)-3-hexenol and linalool in combination with Ph could not induce any male to land on source at all, whereas phenyl acetaldehyde, benzaldehyde, (Z)-6-nonenol and salicylaldehyde combined with Ph enhanced male response rates by 58.63%, 50.33%, 51.85% and 127.78%, respectively, compared to Ph alone. These results suggested that some volatiles shouldmodify sex pheromone caused behavior and that some of them could possibly be used as a tool for disrupting mating or for enhancing the effect of synthetic sex pheromone in the field. | 邓建宇 黄永平 魏洪义 | 2004 | Journal of Zhejiang University Science2004，5，12： | 15 |
| 11 | Study on shift schedule saving energy of automatic transmission of ground vehicles显示文摘To improve ground vehicle efficiency, shift schedule energy saving was proposed for the ground vehicle automatic transmission by studying the function of the torque converter and transmission in the vehicular drivetrain. The shift schedule can keep the torque converter working in the high efficiency range under all the working conditions except in the low efficiency range on the left when the transmission worked at the lowest shift, and in the low efficiency range on the right when the transmission worked at the highest shift. The shift quality key factors were analysed. The automatic trans-mission's bench-test adopting this shift schedule was made on the automatic transmission's test-bed. The experimental results showed that the shift schedule was correct and that the shift quality was controllable. | 龚捷 赵丁选 陈鹰 陈宁 | 2004 | Journal of Zhejiang University Science2004，5，7： | 15 |
| 12 | Preparation of protein samples for gel electrophoresis by sequential extraction显示文摘Since preparation and solubilization of protein samples are crucial factors in proteome research,the authors established a sequential extraction technique to prepare protein samples from the body wall of the 5th instar larvae of silkworm.Bombyx mori.Two kinds of protein samples were obtained from the body wall using the method.Between the two types of samples only about 15% proteins were identical;the majority were different,indicating that more species of proteins could be obtained with the sequential extraction method;which will be useful for preparation of protein samples for proteome study. | 钟伯雄 翁宏飚 等 | 2002 | Journal of Zhejiang University Science2002，3，5： | 15 |
| 13 | Suppressing progress of pancreatitis through selective inhibition of NF-κB activation by using NAC显示文摘Objective:To explore the characteristics of NF-κB activation in the progress of pancreatitis,the relationship with expression of TNF-α in the inflammatory reaction, and prevent the exacerbation of pancreatitis by using NAC.Method:Forty-eight rats were divided into three groups: therapy (group C), pancreatitis (group B) and control (group A).NAC served as the inhibitor of NF-κB activation.In the time intervals of 1.5, 3.0, 6.0, 12.0 hour, NF-κB activation was detected with flow cytometry (FCM) and the expression of TNF-α mRNA and protein with in situ hybridization (ISH) and enzyme-linked immuno-sorbent assay (ELISA) respectively. Meanwhile, the level of lipase and amylase in the serum was assayed and the pathological change was evaluated. Result:NF-κB activation in the pancreatitis group was higher than that in the control group (P<0.01),peaked at 3 hours,and was depressed by the inhibitor of NF-κB, NAC.The expression of TNF-α as well as the level of lipase and amylase in the serum also rose synchronously with activation of NF-κB.In contrast to group A, it was significantly different (P<0.01) in group B.After using NAC in group C,all of these values were decreased and the inflammatory reaction in the pancreas abated evidently. The pathology changes of the pancreas were shown to be alleviated in group C. Conclusion: First,NF-κB activity is intensively initiated in the course of pancreatitis and shown to have closely relationship with the release of cytokines. Second, use of NAC markedly depressed NF-κB activation. TNF-α expression is down regulated by cytokines. It is suggested that NAC probably acts as a useful agent for treatment of pancreatitis by indirectly inhibiting activation of NF-κB. | 赵志成 郑树森 陈文亮 王选 齐莹 | 2004 | Journal of Zhejiang University Science2004，5，4： | 14 |
| 14 | Antioxidant power of phytochemicals from Psidium guajava leaf显示文摘Dried ground leaves ofPsidium guajava L. (guava) were extracted by water and aqueous ethyl alcohol 50%(1:10) ratio, and the total phenolic content in the extracts was determined spectrophotometrically according to FolinCiocalteu's phenol method and calculated as gallic acid equivalent (GAE). Remarkably high total phenolic content 575.3±15.5 and 511.6±6.2 mg of GAE/g of dried weight material (for ethanol guava leaf extracts and water guava leaf extracts,respectively) were obtained. The antioxidant activity of lyophilized extracts was determined at ambient temperature by means of a 2,2-diphenyl-1-picrylhydryzyl (DPPH') colorimetry with detection scheme at 515 nm. The activity was evaluated by the decrease in absorbance as the result of DPPH' color change from purple to yellow. The higher the sample concentration used, the stronger was the free radical-scavenging effect. The results obtained showed that ascorbic acid was a substantially more powerful antioxidant than the extracts from guava leaf. On the other hand, the commercial guava leaf extracts and ethanol guava leaf extracts showed almost the same antioxidant power whereas water guava leaf extracts showed lower antioxidant activity. The parameter EC50 and the time needed to reach the steady state to EC50 concentration (TEC50) affected the antiradical capacity of the sample. The antioxidant efficiency (AE) has been shown to be a more adequate parameter for selecting antioxidants than the widely used ECs0. This study revealed that guava leaf extracts comprise effective potential source of natural antioxidants. | 钱和 NIHORIMBEREVenant | 2004 | Journal of Zhejiang University Science2004，5，6： | 14 |
| 15 | Allograftic bone marrow-derived mesenchymal stem cells transplanted into heart infarcted model of rabbit to renovate infarcted heart显示文摘Objective: To investigate the directed transplantation of allograftic bone marrow-derived mesenchymal stem cells (MSCs) in myocardial infarcted (MI) model rabbits. Materials and Methods: Rabbits were divided into 3 groups, heart infarcted model with MSCs transplanted treatment (MSCs group, n=12), heart infarcted model with PBS injection (control group, n=20), sham operation with PBS injection (sham group, n=17). MSCs labelled by BrdUrd were injected into the MI area of the MSCs group. The same volume of PBS was injected into the MI area of the control group and sham group. The mortality, LVIDd, LVIDs and LVEF of the two groups were compared 4 weeks later. Tropomyosin inhibitory component (Tn Ⅰ) and BrdUrd immunohistochemistry identified the engrafted cells 4 weeks after transplantation. Result: The mortality of the MSCs group was 16.7% (2/12), and remarkably lower than the control group's mortality [35% (7/20) (P<0.05)]. Among the animals that survived for 4 weeks, the LVIDd and LVIDs of the MSCs group after operation were 1.17±0.21cm and 0.74±0.13cm, and remarkably lower than those of the model group, which were 1.64±0.14cm and 1.19±0.12cm (P<0.05); the LVEF of the MSCs group after operation was 63±6%, and remarkably higher than that of the model group, which was 53±6% (P<0.05). Among the 10 cases of animals that survived for 4 weeks in the MSCs group, in 8 cases (80%), the transplanted cells survived in the non MI, MI region and its periphery, and even farther away; part of them differentiated into cardiomyocytes; in 7 cases (70%), the transplanted cells participated in the formation of blood vessel tissue in the MI region. Conclusion: Transplanted allograftic MSCs can survive and differentiate into cardiomyocytes, form the blood vessels in the MI region. MSCs transplantation could improve the heart function after MI. | 王建安 李长岭 樊友启 何红 孙勇 | 2004 | Journal of Zhejiang University Science2004，5，10： | 14 |
| 16 | Anticoagulation therapy in intra-aortic balloon counterpulsation: Does IABP really need anti-coagulation ?显示文摘Objective: To investigate if intra-aortic balloon pump(IABP) is contraindicated without anticoag-ulation therapy. Methods: Some 153 IABP patients in the King Abdulaziz Cardiac Center(KSA) were random-ly assigned into two groups. Anticoagulation group( Group A) consisted of 71 patients who were given heparin intravenously with target aPTT 50 - 70 seconds. Non-anticoagulation group( Group B) consisted of 82 patients without intravenous heparin during balloon pumping. Hematological parameters including platelet count, D-dimer, Plasminogen activator inhibitor-1 (PAI-1) and fibrinogen degradation products(FDP) were checked respectively at the point of baseline, 24 hours, 48 hours and 24 hours post IABP counterpulsation. Clot deposits on balloon surface, vascular complications from IABP including bleeding and limb ischemia were recorded.Results: Platelet count and PAI-1 level decreased at 24 hours and 48 hours in both groups ( P < 0.05) . D-dimer and FDP level increased at 24 hours and 48 hours in both groups( P < 0.05), but returned to the baseline level 24 hours post IABP removal( P > 0.05) . Three patients in Group A and 2 patients in Group B developed minor limb ischemia( P > 0.05). No major limb ischemia in either group. Two patients in Group A suffered major bleeding and required blood transfusion or surgical intervention, whereas no patient had major bleeding in Group B. Eight patients had minor bleeding in Group A, but only 2 patients in Group B ( P <0.05). No clot deposit developed on IABP surface in either group. Conclusion: IABP is safe without routine anticoagulation therapy. Selecting appropriate artery approach and early detection intervention are key methods for preventing complications. | 蒋晨阳 赵莉莉 王建安 单江 MOHAMMODBalgaith | 2003 | Journal of Zhejiang University Science2003，4，5： | 14 |
| 17 | Study on interleukin-18 gene transfer into human breast cancer cells to prevent tumorigenicity显示文摘To study the effect of interleukin-18 gene transfection on the tumorigenesis of breast cancer cell line Bacp37,human breast cancer cell line Bcap37 were transfected with Lipofectamine and selected by G418.The biological expression of rhIL-18 was tested by RT-PCR and ELISA method;nude mice were injected with Bcap37 cell with or without the hIL-18 gene.The hIL-18 cDNA was successfully integrated into Bcap37 cell; 126.3±4.5pg hIL-18 secreted by one million transduced cells in 24 hours. Nude mice injected with IL-18 gene engineered Bcap37 cell had no tumor growth.These findings indicated that human breast cancer cells were successfully modified by the gene of IL-18 cytokine;the IL-18 gene engineered Bcap37 cells secreted hIL-18 and lost their tumorigenicity.The Bcap37 cells transduced with IL-18 gene may be used as breast cancer vaccine. | 韩明勇 郑树 于金明 彭佳萍 郭其森 王家林 | 2004 | Journal of Zhejiang University Science2004，5，4： | 14 |
| 18 | Early association of electrocardiogram alteration with infarct size and cardiac function after myocardial infarction显示文摘Objective:Myocardial infarction (MI) is the main cause of heart failure, but the relationship between the extent of MI and cardiac function has not been clearly determined.The present study was undertaken to investigate early changes in the electrocardiogram associated with infarct size and cardiac function after MI. Methods: MI was induced by ligating the left anterior descending coronary artery in rats. Electrocardiograms, echocardiographs and hemodynamic parameters were assessed and myocardial infarct size was measured from mid-transverse sections stained with Masson's trichrome. Results:The sum of pathological Q wave amplitudes was strongly correlated with myocardial infarct size (r=0.920, P<0.0001), left ventricular ejection fraction (r=-0.868, P<0.0001) and left ventricular end diastolic pressure (r=0.835, P<0.0004).Furthermore, there was close relationship between MI size and cardiac function as assessed by left ventricular ejection fraction (r=-0.913, P<0.0001) and left ventricular end diastolic pressure (r=0.893, P<0.0001).Conclusion: The sum of pathological Q wave amplitudes after MI can be used to estimate the extent of MI as well as cardiac function. | 陶则伟 黄元伟 夏强 傅军 赵志宏 陆贤 BRUCEI.C. | 2004 | Journal of Zhejiang University Science2004，5，4： | 14 |
| 19 | Inducible nitric oxide synthase expression is related to angiogenesis,bcl—2 and cell proliferation in hepatocellular carcinoma显示文摘In this study,we examined the expression of inducible nitric oxide synthase(iNOS) and vascular endothelial growth factor(VEGF) by immunohistochemical staining in 76 tissue sections collected from bepa-tocellular carcinoma(HCC) patients undergoing hepatectomy.Microvascular density (MVD) was determined by counting endothelial cells immunostained using anti-CD34 antibody.We performed DNA-flow cytometric analyses to elucidate the impact of iNOS and VEGF expression on the cell cycle of HCC.Most of the HCC cells that invaded stroma were markedly immunostained by iNOS antibody.The iNOS stain intensity of the liv-er tissue close to the tumor edge was stronger than that of HCC tissue,and the strongest was the hepatocytes colser to the tumor tissue.However,iNOS expression in 10 normal hepatic samples was undetectable.VEGF positive expression ratio was 84.8% in iNOS positive expression cases,and the ratio was 35.3% in negative cases.There was significant correlation(P=0.000) between iNOS and VEGF expression.Moreover,iNOS expression was significantly associated with bcl-2 and MVD,but without p53 expression.DNA-flow cytometric analyses showed that combined expression of iNOS and VEGF had significant impact on the cell cycle in HCC.PI(Proliferating Index) and SPF(S-phase fraction)in the combined positive expression of iNOS and VEGF group was significantly higher than that in the combined negative group.The present findings suggested that iNOS expression was significantly associated with angiogenesis,bcl-2 and cell proliferation of HCC. | 彭佳萍 郑树 孝作祥 张苏展 | 2003 | Journal of Zhejiang University Science2003，4，2： | 13 |
| 20 | Treatment of chitin-producing wastewater by micro-electrolysis-contact oxidization显示文摘The technique of micro-electrolysis-contact oxidization was exploited to treat chitin-producing wastewater.Results showed that Fe-C micro-electrolysis can remove about 30% CODcr, raise pH from 0.7 to 5.5.The CODcr removal efficiency by biochemical process can be more than 80%. During a half year's operation,the whole system worked very stably and had good results, as proved by the fact that every quality indicator of effluent met the expected discharge standards; which means that chitin wastewater can be treated by the technique of micro-electrolysis, contact oxidization. | 杨岳平 徐新华 陈海峰 | 2004 | Journal of Zhejiang University Science2004，5，4： | 13 |
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