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| 1 | Clinical implication of VEGF serum levels in cirrhotic patients with or without portal hypertension显示文摘INTRODUCTIONAngiogenesisorformationofnewbloodvesels,isatightlyregulatedprocesinwhichbloodveselssupplygrowingtisuewithnutrient... | Nimer Assy 1,4 , M Paizi 3,4 , D Gaitini 2, Y Baruch 1,4 and G Spira 3,4,5 | 1999 | World Journal of Gastroenterology1999，5，4： | 35 |
| 2 | Caveolin-1 gene silencing promotes the activation of PI3K/AKT dependent on Erα36 and the transformation of MCF10A^(CE)显示文摘ERα36,a variant of estrogen receptor-α,acts as a dominant-negative factor in both estrogen-dependent and estrogen-independent transactivation signaling pathways,and is a key factor in the promotion,progression and prognosis of breast cancers.Caveolin-1,a 22-to 24-kD integral membrane protein,may function as a tumor suppressor in inhibiting of many growth-promoting signaling pathways.It was shown that downregulation of Caveolin-1 strengthens the interaction of ERα and Caveolin-1.In conclusion,Caveolin-1 gene silencing activated the PI3K/AKT signaling pathway in an ERα36-dependent way.Our finding may provide a promising therapeutic target of breast cancer. | FENG Shuang1,WANG Yang1,WANG Xi1,WANG ZhaoYi3,CUI YuYing1,LIU Jing4,ZHAO ChunHui1,JIN Mei1,2 & ZOU Wei1,2 1 College of Life Science,Liaoning Normal University,Dalian 116029,China 2 Liaoning Key Laboratory of Biotechnology and Molecular Drug R&D,Dalian 116029,China 3 Cancer Center,Creighton University,2500 California Plaza,Omaha,NE 68178,USA 4 First Clinical Hospital of Dalian Medical University,Dalian 116011,China | 2010 | Science China(Life Sciences)2010，53，5： | 16 |
| 3 | Enhancing disease resistances of Super Hybrid Rice with four antifungal genes显示文摘A plant expression vector harboring four antifungal genes was delivered into the embryogenic calli of ‘9311’, an indica restorer line of Super Hybrid Rice, via modified biolistic particle bombardment. Southern blot analysis indicated that in the regenerated hygromycin-resistant plants, all the four anti-fungal genes, including RCH10, RAC22, β-Glu and B-RIP, were integrated into the genome of ‘9311’, co-transmitted altogether with the marker gene hpt in a Mendelian pattern. Some transgenic R1 and R2 progenies, with all transgenes displaying a normal expression level in the Northern blot analysis, showed high resistance to Magnaporthe grisea when tested in the typical blast nurseries located in Yanxi and Sanya respectively. Furthermore, transgenic F1 plants, resulting from a cross of R2 homo-zygous lines with high resistance to rice blast with the non-transgenic male sterile line Peiai 64S, showed not only high resistance to M. grisea but also enhanced resistance to rice false smut (a disease caused by Ustilaginoidea virens) and rice kernel smut (another disease caused by Tilletia barclayana). | ZHU HuaChen1, XU XinPing1, XIAO GuoYing2,3, YUAN LongPing2 & LI BaoJian1 1 Biotechnology Research Center, Key Laboratory of Gene Engineering of Ministry of Education, Sun Yat-sen University, Guangzhou 510275, China 2 China National Hybrid Rice R&D Center, Hunan Hybrid Rice Research Center, Changsha 410125, China 3 Institute of Subtropical Agriculture, the Chinese Academy of Sciences, Changsha 410125, China | 2007 | Science China(Life Sciences)2007，50，1： | 6 |
| 4 | The influence of impurity on the critical thickness of the CeO_2 buffer layer for coated conductors显示文摘The lattice parameters, band structure, density of state and elastic constant of RE-doped CeO2 (RE=Sm, Gd, Dy), the buffer material for coated HTS conductors, are calculated using the plane-wave method with pseudopotentials based on the density functional theory (DFT) of first-principle. The rule and mechanism of the effect of rare earth impurity on the critical thickness of the CeO2 buffer layer are investigated. It is found that, in the range of the calculation, the changes of the lattice volume V and elastic constant E of CeO2 with the impurity are mainly determined by the increased electrons ne of the system. The relationship of the elastic constant E and increased electrons ne is established. It is indicated that the critical thickness of the CeO2 single buffer layer doped with Sm, Gd, and Dy may be enhanced by 22%, 43% and 33%, respectively. | PAN Min1, HUANG Zheng2, MA HuanFeng2, QIANG WeiRong2, WEI LianFu1, WANG Long2 & ZHAO Yong1,3 1 Key Laboratory of Magnetic Levitation Technologies and Maglev Trains (Ministry of Education of China), Superconductivity R&D Center (SRDC), Southwest Jiaotong University, Chengdu 610031, China 2 School of Physical Science and Technology, Southwest Jiaotong University, Chengdu 610031, China 3 Superconductivity Research Group, School of Materials Science and Engineering, University of New South Wale, Sydney, 2052 NSW, Australia | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，7： | 3 |
| 5 | The effects of K^+ growth conditions on the accumulation of cesium by the bacterium Thermus sp. TibetanG6显示文摘The accumulation of cesium by the bacterium Thermus sp. TibetanG6 was examined under different K+ growth conditions. The effects of external pH and Na+ on the accumulation of ce-sium were also studied, and the mechanism involved was discussed. K+ regimes played an important role in the accumulation of cesium by the strain TibetanG6. The quantity of cesium accumulated (24 h) was much higher in K+-deficient regime than that in K+-sufficient regime. The pH and Na+ had different effects on the accumulation of cesium in the two K+ regimes. IR spectra analyses indicated that the biosorption is a process of homeostasis with cesium initially accumulated on the cell wall. | WANG Hailei1,2,3, KONG Fanjing1,2,3 & ZHENG Mianping1,2,3 1. R&D Center for Saline Lake and Epithermal Deposits, Chinese Academy of Geological Sciences, Beijing 100037, China 2. Key Open Laboratory of Saline Lake Resources and Environment, Chinese Academy of Geological Sciences, Beijing 100037, China 3. Institute of Mineral Resources, Chinese Academy of Geological Sciences, Beijing 100037, China | 2006 | Science China(Life Sciences)2006，49，2： | 3 |
| 6 | BATE curve in assessment of clinical utility of predictive biomarkers显示文摘In this paper,for time-to-event data,we propose a new statistical framework for casual inference in evaluating clinical utility of predictive biomarkers and in selecting an optimal treatment for a particular patient.This new casual framework is based on a new concept,called Biomarker Adjusted Treatment Effect (BATE) curve.The BATE curve can be used for assessing clinical utility of a predictive biomarker,for designing a subsequent confirmation trial,and for guiding clinical practice.We then propose semi-parametric methods for estimating the BATE curves of biomarkers and establish asymptotic results of the proposed estimators for the BATE curves.We also conduct extensive simulation studies to evaluate finite-sample properties of the proposed estimation methods.Finally,we illustrate the application of the proposed method in a real-world data set. | ZHOU XiaoHua 1,2,3,& MA YunBei 4,5 1 Northwest HSR&D Center of Excellence,VA Puget Sound Health Care System,Seattle,WA 98198,USA 2 Department of Biostatistics,University of Washington,Seattle,WA 98198,USA 3 Beijing International Center for Mathematical Research,Peking University,Beijing 100871,China 4 Department of Operations Research and Financial Engineering,Princeton University,Princeton,NJ 08540,USA 5 School of Statisitcs,Southwest University of Finance and Economics,Chengdu 611130,China | 2012 | Science China Mathematics2012，55，8： | 2 |
| 7 | Cesium accumulation by bacterium Thermus sp. TibetanG7:hints for biomineralization of cesium-bearing geyserite in hot springs in Tibet,China显示文摘The bacterium Thermus sp. TibetanG7, isolated from hot springs in Tibet, China, was examined for the ability to accumulate cesium from solutions. Environmental conditions were simulated and the effects of pH, K+, Na+ and K+-regimes were then studied to determine the possible role of the bacterium in the formation of cesium-bearing geyserite around these hot springs. In despite of the inhibition of K+ and Na+, the bacterium Thermus sp. TibetanG7 revealed noticeable accumulation of cesium from solutions, with maximum accumulations of 53.49 and 40.41 μmol Cesium/g cell dry weight in Na+ and K+ inhibition experiments, respectively. The accumulation of cesium by this microorganism is rapid, with 40%―50% accumulated within the first 5 min. K+-deficient cells showed a much higher capacity of cesium accu- mulation compared with K+-sufficient cells. It is evident that the bacteria within the genus thermus play a significant role in the cesium assembly. The formation of cesium-bearing geyserite is also considered. | WANG HaiLei1,2,3, ZHENG MianPing1,2,3 & HUANG XiaoXing4 1 Institute of Mineral Resources, Chinese Academy of Geological Sciences (CAGS), Beijing 100037, China 2 R&D Center for Saline Lake and Epithermal Deposits, CAGS, Beijing 100037, China 3 Open Laboratory of Saline Lake Resourses and Environment, CAGS, Beijing 100037, China 4 Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100081, China | 2007 | Chinese Science Bulletin2007，52，19： | 2 |
| 8 | Synthesis of a 3D graph- ite microball using a microfluidic droplet generator and its pol- ymer composite with core-shell structure 显示文摘 | Flan D 3 Jung ] H Choi J S etal | 2013 | Lab on a Chip2013，13，20： | 1 |
| 9 | ^13C-NMR relaxation studies on cartilage and cartilage eomponents显示文摘 | L Naji 3 Kaufmann D Huster | 2000 | Carbohydr Res2000，327，4： | 1 |
| 10 | A research on short term load forecasting problem applying improved grey dynamic model 显示文摘 | Li (3 D Wang C H Masuda S | 2011 | ElectricalPower and Energy Systems2011，，33： | 1 |
| 11 | Proposed international clinical diabetic retinopathy and diabetie macular edema disease severity scales 显示文摘 | Wilkinson C P Ferris FL 3 rd Klein RE Lee PP Agardh C D Davision M | 2003 | Ophthalmology2003，110，9： | 1 |
| 12 | Air pollution removal by urban trees and shrubs in the United States显示文摘 | Nowak D J Crane D E Stevens J (3 | 2006 | Urban Forestry and Urban Greening2006，4，34： | 1 |
| 13 | Pravastatin and the development of diabetes meUitus: evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study显示文摘 | Freeman D J Norrie 3 Sattar N | 2001 | Circulation2001，103，3： | 1 |
| 14 | A study of anti-conosion behavior of octadecylamine-treated iron samples 显示文摘 | GE H H ZHOU (3 D LIAO Q Q | 2000 | Applied Surface Science2000，156，14： | 1 |
| 15 | Noninvasive assess- ment of cardiac diabetic neuropathy by HC-hydroxyephedrine and positron emission tomography显示文摘 | Allman K C Stevens M 3 Wieland D M | 1993 | J Am Coil Cardiol1993，22，6： | 1 |
| 16 | The harmonious coloring number of a graph 显示文摘 | 3,MILLER Z PRITIKINK D | 1991 | Discrete Math1991，93，： | 1 |
| 17 | Volatile compounds in ehorizo and their changes during ripening显示文摘 | MATEO 3 ZUMALAC~d~ REGUI J | 1996 | Meat Science1996，44，4： | 1 |
| 18 | 6-meter telescope显示文摘 | Vigil Michael L Witte David J LeVan Paul D et aL Sensor suite for the advanced electro-optical system (AEOS) 3 | 1996 | SPIE1996，2819，： | 1 |
| 19 | Pharmacodynamics of subcutaneous recombinant human interleukin -10 inheadthy volunteers显示文摘 | Richard D Radwanski E Gallo 3 | 1997 | Clin Pharmacol Ther1997，62，2： | 1 |
| 20 | A comparative study of plant re- sponsiveness to the duration of episodes o: mineral nutrient en- richment 显示文摘 | Campbell ]3 D Grime J P | 1989 | New Phytology1989，112，2： | 1 |
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