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    题名 作者 年代 出处 被引量
1人文关怀护理行为感知的研究现状显示文摘论述了人文关怀的内涵,人文关怀护理行为感知研究的重要性和必要性,人文关怀护理行为感知存在差异以及护理人文关怀的测评工具,旨在为患者进一步提供有效的人文关怀护理,同时为管理者和职能部门制定有关决策提供参考。张丽华 郑海英 邓桂萍 刘莉 贺巧玲 方闯 2013护理学杂志(综合版)2013,28,11:31
2基于数据挖掘技术探析近5年穴位埋线治疗单纯性肥胖的取穴规律显示文摘运用数据挖掘技术探析近5年来穴位埋线治疗单纯性肥胖的取穴特点和规律、埋线处方使用规律。天枢为穴位埋线治疗单纯性肥胖使用频次最高的腧穴,胃经用穴最多,常用穴位主要分布于胸腹部,特定穴中募穴使用率最高,处方穴位以10~20个穴位使用为多,埋线次数以1~10次使用为多,埋线时间以5~15 d1次为优选。柯超 杜鸿蒙 单生涛 邓泽成 唐玲 方闯 章薇 2018中医药导报2018,24,18:10
3基于胶质细胞源性神经营养因子甲基化修饰探讨电针改善慢传输型便秘大鼠肠动力的作用机制显示文摘目的:观察电针大肠俞募穴'天枢''大肠俞'对慢传输型便秘(STC)大鼠肠道传输功能的改善情况,通过检测大鼠结肠组织胶质细胞源性神经营养因子(GDNF)的表达以及GDNF基因启动子区CpG岛甲基化状态,探讨电针治疗STC的可能机制。方法:雄性SD大鼠随机分为正常组、盐水组、模型组和电针组,每组16只。采用15 mg/mL复方地芬诺酯混悬液灌胃(10 mL·kg^(-1)·d^(-1))复制STC大鼠模型。盐水组予同等剂量的0.9%氯化钠溶液灌胃。电针组电针双侧'天枢''大肠俞',每次15 min,1次/d,连续14 d。观察大鼠排便情况并检测大鼠肠道传输功能;采用透射电镜观测结肠组织Cajal间质细胞(ICC)超微结构;Western blot法、实时荧光定量PCR法检测结肠组织中GDNF蛋白、mRNA的表达;重亚硫酸盐测序法检测结肠组织GDNF基因启动子区CpG岛甲基化状态。结果:与正常组、盐水组比较,模型组大鼠24 h排便量下降(P<0.01),粪便性状评分降低(P<0.05),小肠推进率下降(P<0.01),ICC形态结构遭到破坏,结肠组织GDNF蛋白及mRNA表达降低(P<0.01),GDNF基因启动子区CpG岛甲基化阳性率升高(P<0.05)。与模型组比较,电针组大鼠24 h排便量增多(P<0.01),粪便性状评分升高(P<0.05),小肠推进率明显升高(P<0.01),损伤的ICC超微结构得到部分修复,结肠组织GDNF蛋白及mRNA表达升高(P<0.05),GDNF基因启动子区CpG岛甲基化阳性率降低(P<0.05)。结论:电针大肠俞募配穴可促进结肠组织GDNF的表达,有效改善STC大鼠的便秘症状,修复结肠组织超微结构,从而调整肠道传输功能,其中结肠组织GDNF基因启动子区甲基化状态的改变可能是电针大肠俞募配穴治疗STC的重要机制之一。曹洋 钟峰 文钱 方闯 夏叶婉 罗容 匡泓俊 章薇 2022针刺研究2022,47,2:10
4基于CiteSpace的近20年针灸治疗原发性高血压的研究图谱分析显示文摘目的为了将近20年针灸治疗原发性高血压(EH)的相关文献进行可视化分析,得出该领域的研究热点及研究趋势。方法运用CiteSpace软件对2001年1月至2021年6月中国知网针灸治疗EH相关文献的作者、机构、关键词、研究热点进行了可视化分析,并且绘制了图谱。结果共纳入文献773篇;纳入作者504名,形成王舒、石学敏、梁繁荣3个影响较大的研究团队。天津地区研究机构以天津中医药大学第一附属医院为核心,形成研究优势网络。关键词共现结果显示,排名前5的关键词依次为原发性高血压、针刺、高血压、高血压病、针刺疗法。关键词共现网络中中心性排名前16的关键词可分为4类:疾病、治疗方法、穴位、机制研究。热点突出词结果显示,研究热点大致可分为以下几类:关于穴位研究热点有风池穴、人迎穴、曲池穴;疗法研究热点有针灸疗法;机制基础研究热点有:基因芯片、下丘脑、一氧化氮;临床疗效评价研究热点有即时降压、心率变异率、血压昼夜节律。结论近20年间国内对于针灸治疗EH的研究,形成以天津地区的区域优势网络,形成了多个影响较大的研究团队。且疗效评估趋于多元化,但存在基础研究较为薄弱的问题。牛子青 郑璇 刘小娟 谭艳 曹越 方闯 包成通 章薇 2022中国医药导报2022,19,6:7
5卡尔加里-剑桥指南在急诊科护生沟通技巧培训中的应用显示文摘目的探讨卡尔加里-剑桥指南(下称指南)在急诊实习护生沟通技巧培训中的应用效果。方法将急诊科实习护生63名按入科实习时间分为观察组(32例)和对照组(31例),观察组接受指南进行沟通技巧的培训,对照组接受常规沟通指导;采用护患沟通满意度调查问卷A、B卷调查两组护生所服务的患者和两组护生的沟通满意度情况。结果观察组患者护患沟通总体满意度和11个条目(除外'保护隐私')显著优于对照组(P<0.05,P<0.01);观察组护生沟通总体满意度及沟通过程中的8个条目(除外'有礼貌、尊重患者'及'保护隐私'等4个条目)显著优于对照组(P<0.05,P<0.01)。结论指南可有效提高急诊患者及实习护生对沟通过程的满意度。张丽华 阮满真 李华 向莉 冯霞 刘丽 方闯 贺巧玲 2012护理学杂志(综合版)2012,27,6:7
6针灸并用结合康复训练治疗中风后肩手综合征临床疗效观察显示文摘Objective:To compare the clinical effects of body acupuncture,moxibustion,and body acupuncture plus moxibustion in the treatment of post-stroke shoulder hand syndrome(SHS).Methods:A total of 90 SHS patients after stroke were randomly divided into the body acupuncture group,the moxibustion group,and the body acupuncture plus moxibustion group,with 30 cases in each.On the basis of rehabilitation and routine treatment,the patients in different groups were treated with body acupuncture,moxibustion,and body acupuncture plus moxibustion respectively.Treatment was given once a day,5 times a week,and 4 weeks in all.The visual analogue scale(VAS)scores,edema grading scores,and simplified Fugl-Meyer assessment(FMA)scores were evaluated before and after treatment,and the therapeutic effects of patients were evaluated as well.Results:After treatment,the VAS and edema grading scores of the three groups were all lower and the FMA scores were all higher than those before treatment,with statistically significant differences(all P<0.05).The VAS and edema grading scores of the acupuncture plus moxibustion group were lower and the FMA score was higher than those of the body acupuncture group and the moxibustion group,with statistically significant differences(all P<0.05).The total effective rate of the acupuncture plus moxibustion group was 96.7%,higher than 80.0%of the body acupuncture group and 83.3%of the moxibustion group,with statistically significant differences(both P<0.05).Conclusion:Body acupuncture,moxibustion,and body acupuncture plus moxibustion are all effective for post-stroke SHS,while the effect of acupuncture plus moxibustion is the best in relieving the pain and swelling,and improving effectively the joint movement of post-stroke SHS patients,which should be popularized in clinical practice.潘江 曹洋 方闯 张彦 唐锦忠 章薇 王诚喜 2020World Journal of Acupuncture-Moxibustion2020,30,2:7
7浅析不同针法治疗阿尔兹海默病的研究进展显示文摘针灸治疗阿尔兹海默病(Alzheimer’s disease, AD)具有早期性、安全性、有效性、良性双向调整的优势。根据AD发病的不同病因病机特点,学者们将其和针灸理论相结合,提出不同的针灸治则和选穴处方,如嗅三针法、益肾调督针法、三焦针法等。不同学术思想的出现往往有利于百家争鸣,就不同针法治疗AD进行综述,可为临床提供一定的理论基础。柯超 曹洋 夏叶婉 方闯 施森杰 石文英 潘江 章薇 2022湖南中医药大学学报2022,42,2:5
8高血压患者发生复杂心律失常的危险因素分析显示文摘目的:通过与简单心律失常对比探讨影响原发性高血压患者发生复杂心律失常的危险因素。方法:回顾性分析我院接诊的149例原发性高血压患者的临床资料。按照Lown’s标准及Kleiger分级法将患者分为简单心律失常组与复杂心律失常组,采用多因素Logistic回归分析患者年龄、病程、高血压危险分级、性别、吸烟史、饮酒史、体质指数(BMI)、左心室舒张期后壁厚度(LVPWD)及左心房内径(LAD)与发生复杂心律失常的关系。结果:原发性高血压患者年龄≥60岁者复杂心律失常的发生率显著高于60岁以下者(χ^(2)=17.494,P <0.01),病程≥5年者显著高于病程<5年者(χ^(2)=18.073,P <0.01),饮酒者显著高于无饮酒者;复杂心律失常的发生与左室壁厚度及左房直径无关(χ^(2)=5.36,P=0.026)。多因素分析示年龄(OR=0.323,95%CI为0.155~0.674,P=0.003)及病程(OR=0.299,95%CI为0.141~0.635,P=0.002)为高血压患者发生复杂心律失常的独立危险因素。结论:原发性高血压年龄≥60岁、病程≥5年者发生复杂心律失常的风险较高。林琳 宋芷薇 刘艳鑫 方闯 吴家宽 2021现代医学2021,49,5:5
9手卫生口诀在急诊科护生手卫生培训中的应用显示文摘目的探讨手卫生口诀在急诊科护生手卫生培训中的作用。方法按实习时间顺序将2011年7~12月急诊科实习护生45名设为对照组,采用传统的教学方法进行手卫生培训;2012年7~12月急诊科实习护生45名设为观察组,采用手卫生口诀进行培训。结果观察组护生手卫生执行率、手卫生理论和七步洗手法考试成绩、对手卫生培训的肯定率显著高于对照组(均P〈0.01)。结论采用手卫生口诀对急诊科护生进行手卫生培训,能使护生养成良好的手卫生习惯,提高手卫生的执行率。吴晓燕 贺巧玲 黄梅 陈艾华 彭琳 方闯 2014护理学杂志(综合版)2014,29,4:5
10近10年针灸治疗慢性胃炎的现代文献选穴规律探析显示文摘Objective To summarize the acupoint selection rule for chronic gastritis treated with acupuncture and moxibustion so as to provide a certain evidence for clinical practice and scientific research.Methods By searching journal literature on chronic gastritis treated with acupuncture and moxibustion in recent 10 years,with data mining,the acupoints screened from literature were analyzed.Results A total of 803 articles were included finally.Conception vessel,stomach meridian and bladder meridian were mostly selected,the acupoints were selected from the abdomen,the thigh/crus,the back and the arms.The top 5 aucpoints with high frequency were Zúsānǐ(足三里ST36),Zhōngwǎn(中脘CV12),Wèishū(胃俞BL21)(332),Píshū(脾俞BL20)and Nèiguān(内关PC6).The top 5 acupoint combinations with high frequency included CV12 combined with ST36,BL21 with CV12,BL21 with ST35 and BL20 with CV12.The mostly used specific points were front-mu point,he-sea point,crossing point and back-shu point.Conclusion In treatment of chronic gastritis with acupuncture and moxibustion,conception vessel,stomach meridian and bladder meridian are particularly selected in combination and the specific points with duplicate effect are mostly selected,especially focusing on the application of front-mu point.方闯 曹洋 潘江 肖豆 柯超 牛子青 夏叶婉 章薇 2022World Journal of Acupuncture-Moxibustion2022,32,2:4
11石灰石作水泥混合材的研究显示文摘石灰石作水泥混合材的研究侯宪钦高培伟(山东建材学院)方闯烈卢小琳(华东化工学院)中图分类号TQ172.04前言长期以来,石灰石被认为是惰性混合材,只是在水泥超标号时为降低成本而允许在水泥中少量掺入,经大量研究改变了这种认识。近几年来,在波特兰水泥中掺...侯宪钦 高培伟 方闯烈 卢小琳 1998山东建材1998,,1:4
12船舶静力学计算及稳性衡准系统的设计和实现显示文摘详述了船舶静力学计算及稳性衡准系统的一种设计与实现方案。系统由初始数据输入、系统内核计算、计算结果显示三个模块构成。系统实现是以Sybase作为后台数据库管理船舶静力学及稳性衡准计算的输入以及计算结果数据,以VisualBasic.NET作为开发平台来实现各项具体功能。对B样条的计算方法作为本系统中船舶静力学及稳性衡准计算的核心基础算法进行了详尽叙述。从船舶CAD设计文件中智能获取船舶型值信息(从而大大减少系统用户的输入工作量)是本系统实现的突出特点。石国政 侯国祥 方闯 祝玉梅 许士华 2006中国舰船研究2006,1,4:3
13黄磷罐式集装箱的强度计算与测试显示文摘刘道忠 朱国文 荆浩明 方闯 2006集装箱化2006,17,5:3
14针灸效应机制中外泌体的研究进展显示文摘外泌体是一种纳米级大小、分布广泛且可以传递细胞间信息的胞外囊泡样小体。新近研究表明外泌体能反应针灸对机体的调控,其为针灸效应机制研究提供新的线索。通过检索国内外外泌体在针灸效应机制中的研究文献,阐述针灸是如何通过调控外泌体起效,以及外泌体、针灸、机体三者之间的关系。在此基础上,分析其研究现状以及存在的问题。参考文献33篇。匡泓俊 黄文豪 李星慧 方闯 包成通 牛子青 钟峰 2021山东中医药大学学报2021,45,5:3
15针刺治疗卵巢早衰临床疗效Meta分析显示文摘目的:利用Meta分析方法评价针刺治疗卵巢早衰(premature ovarian failure,POF)的随机对照试验的临床疗效。方法:检索循证临床证据数据库Cochrane Library、PubMed、EMBASE(涵盖MEDLINE)、中国知网、维普以及万方数据知识服务平台文献。文献中试验组为单纯针刺治疗,对照组为空白对照、安慰剂、假针刺或阳性药物,或某种干预措施同时用于试验组和对照组。评价最终纳入文献质量,并采用RevMan 5.3软件分别对亚组(单纯针刺治疗和针刺辅助激素治疗)进行Meta分析。结果:最终纳入11篇随机对照试验文献,共725例患者。文献质量为中、低级。针刺治疗能降低卵泡刺激素(follicle-stimulating hormone,FSH),SMD=-0.59,95%CI[-0.77,-0.40];增加月经恢复例数,RR=1.28,95%CI[1.15,1.43];升高雌二醇(estradiol,E_(2)),SMD=1.38,95%CI[0.90,1.86]。结论:针刺可有效治疗POF,降低血清FSH,改善月经情况及升高E_(2)水平。但目前证据尚不充分,需更多高质量研究增强结论的可靠性。刘小娟 石文英 谭志高 方闯 牛子青 章薇 2022西部中医药2022,35,9:3
16内河船舶极限总强度的试验研究显示文摘介绍了有关内河船舶极限总强度的一些试验研究工作 ,重点考察了不同骨架形式对船体总纵极限强度的影响 ,得出了一些具有实用意义的结论。方闯 张文涛 黄震球 陈齐树 2001船舶工程2001,,1:3
17TGF-β/SMAD4信号通路中基因突变对胰腺癌患者生存的影响显示文摘目的:分析胰腺导管腺癌患者转化生长因子(TGF)-β/SMAD4信号通路中基因突变的情况及对生存的影响。方法:回顾性分析天津医科大学总医院普通外科2016年7月—2019年9月共19例胰腺导管腺癌患者的临床资料,NGS检测患者基因突变情况,查询dbSNP及COSMIC数据库关键基因突变位点的临床意义。结果:19例胰腺导管腺癌患者中最常见的基因突变是KRAS(84.2%)、TP53(68.4%)、SMAD4(26.3%)、CDKN2A(26.3%)、CREBBP(15.8%)、RNF43(15.8%)、BRAF(15.8%)等。具有TGF-β/SMAD4信号通路相关基因突变的患者有7例(36.8%),其中SMAD4基因突变组中位生存时间5.0个月,无SMAD4基因突变组中位生存时间14.0个月,差异有统计学意义(P=0.032)。结论:TGF-β/SMAD4信号通路中具有SMAD4基因突变患者的临床预后相较于无基因突变患者的临床预后更差,此通路中具有多个基因突变其预后相对更差。方闯 田伟军 2020天津医科大学学报2020,26,5:3
18弯载下砂岩声发射特征值时间效应显示文摘为探索开采速度对采空区顶板破断特征影响的力学机制,设定不同加载速率,开展砂岩3点弯曲和声发射试验,研究砂岩弯曲折断过程的力学行为及其受加载速度影响的时间效应和折断前兆特征。结果表明,加载速率越快,砂岩显著初始损伤声发射发生的应力条件越高,积累的应变能越高;岩石折断前,前兆声发射时间长度与加载速率呈指数负相关,加载速度越快,前兆声发射时间越短,可预测性越差;加载速率与砂岩折断声发射峰值能量及破坏载荷呈指数正相关,与砂岩折断声发射峰值计数呈指数负相关,加载速度越快,岩石折断所需的破坏荷载越大,峰值声发射计数越少,一次性释放的能量越高。上述岩石弯曲声发射特征值是加载速率的函数,存在时间效应。从机理上解释了煤矿开采速度越高,顶板岩体动力灾害危险性相对越高,可预测性越差的原因。李铁 李柯萱 皮希宇 方闯 2018煤炭学报2018,43,11:2
19基于数据挖掘探析慢性胃炎古代针灸选穴规律显示文摘Objective:To explore the experiences of ancient acupuncture physicians in acupoint combination with meridians and body regions involved in treatment of chronic gastritis through data mining technology so as to provide the evidences for the clinical application of acupuncture for chronic gastritis in the modem time.Methods:Firstly,the ancient literature(database),searching words,inclusion and exclusion criteria were determined.Secondly,the database was organized through computer and manual retrieval.Finally,using data mining techniques,such as frequency analysis and association analysis,the experiences of ancient acupuncture physicians were explored in meridian selection and acupoint combination in treatment of chronic gastritis.Results:A total of 2243 items in compliance with the relevant requirements were included,covering224 acupoints for the treatment of chronic gastritis.Of them,the involved meridians were closely related to the stomach,especially to bladder,spleen and stomach meridians as well as Conception Vessel.The acupoints selected not only focus on the local acupoints related to lesions,but also on the distal ones,especially those located in the lower limbs.The most common acupoints for any symptom were Zusanli(足三里ST36),Neiguan(内关PC6),Zhongwan(中脘CV12),Gongsun(公孙SP4)and Taibai(太白SP3).For epigastric pain,Liangmen(梁门ST21)and Xiangu(陷谷ST43)were the representatives as the combination of acupoints from the same meridian.For the disorders with upward reversion of qi,PC6 and SP4 were generally combined.Among the specific points,the five-shu points were the most common,followed by the front-mu points.In the combination with the specific points involved,PC4 and SP4 were highly associated.The acupoint combination was particular for each category of main symptoms.Conclusion:In treatment of chronic gastritis with acupuncture,the ancient physicians give the great consideration to symptom differentiation and meridian differentiation relevant with gastric disorders,as well as the combination of the distal and nearby acupoints.Besides,the specific points are of the best choice.张培铭 章薇 谭志高 刘小娟 潘婷 肖豆 陈德祯 方闯 2021World Journal of Acupuncture-Moxibustion2021,31,2:2
20针刺治疗慢性前列腺炎——随机临床试验显示文摘Objective:To explore whether there is a specific clinical effect of acupuncture in the treatment of chronic prostatitis.Methods:A total of 52 patients with chronic prostatitis were randomly divided into an acupuncture group(24 cases) and a placebo acupuncture group(28 cases).During the treatment,1 case was dropped out in the placebo acupuncture group and 51 patients accomplished the clinical trial finally in two groups.In the acupuncture group,Shènshū(肾俞BL23),Zhōngliáo(中髎BL33),Huìyáng(会阳BL35) and Sānyīnjiāo(三阴交SP6) were selected.In the placebo acupuncture group,the non-meridian points located lateral to BL23,BL33,BL35 and SP6 were selected,respectively.The duration of treatment was 8 weeks in each group.In the first 4 weeks of treatment,the treatment was given once every two days,three times weekly.In the last 4 weeks of treatment,the treatment was given once every three days,twice a week.Totally,20 acupuncture treatments were required in the whole trial.Before treatment,in week 4 and 8 of treatment and in follow-up,National Institutes of Health Chronic Prostatitis Symptom Index(NIH-CPSI) score and the comprehensive effect were evaluated in the two groups successively.Results:In week 4 and 8 of treatment,NIH-CPSI score in the acupuncture group was lower than that before treatment,respectively(both P <0.05).In week 8 of treatment,NIH-CPSI score in the placebo acupuncture group was lower than that before treatment(P <0.05).NIH-CPSI score in the acupuncture group was lower than the placebo acupuncture group in week 8 of treatment(P <0.05).In followup,NIH-CPSI score of the two groups all decreased as compared with the score before treatment(both P <0.05),and the score in the acupuncture group was lower than the placebo acupuncture group(P <0.05).In the comparison of comprehensive effect,the total effective rate was 91.7% in the acupuncture group and was 74.1% in the placebo acupuncture group.The therapeutic effect in the acupuncture group was better than that of the placebo acupuncture group(P <0.05).Conclusion:Acupuncture relieves pelvic pain and urination symptoms and has a certain of long-term effect in patients with chronic prostatitis.谢峥嵘 邓泽成 肖豆 石文英 钟峰 唐媛媛 方闯 王鑫 柯超 章薇 2022World Journal of Acupuncture-Moxibustion2022,32,3:2
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