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| 1 | Viral hepatitis prevalence in patients with active and latent tuberculosis显示文摘AIM: To assess the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and association with drug induced liver injury(DILI) in patients undergoing anti-tuberculosis(TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB- either active disease or latent infection- who were due to commence antiTB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus(HIV) infections- hepatitis B core antigen(HBc Ag), hepatitis B surface antigen(HBs Ag), hepatitis B e antigen, Ig G and Ig M antibody to HBc Ag(anti-HBc), HCV Ig G antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of antiTB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher's exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270(62.9%) had active TB disease and 159(37.1%) had latent TB infection. 61(14.2%) patients had isolated anti-HBc positivity, 11(2.6%) were also HBs Ag positive and 7(1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis(HBs Ag or HCV antibody positive; P = 0.023). Similarly the proportion of HBs Ag positive patients were significantly greater in the active vs latent TB infection group(10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each. We found no association between DILI and presence of serological markers of HBV or HCV. Three(5.3%) patients with serological markers of HBV or HCV infection had DILI compared to 25(9.5%) patients without; P = 0.04.CONCLUSION: Viral hepatitis screening should be considered in TB patients. DILI risk was not increased in patients with HBV/HCV. | Hesam Ahmadi Nooredinvand David W Connell Mahmoud Asgheddi Mohammed Abdullah Marie O'Donoghue Louise Campbell Melissa I Wickremasinghe Ajit Lalvani Onn Min Kon Shahid A Khan | 2015 | World Journal of Gastroenterology2015，21，29： | 7 |
| 2 | Zinc - nickel alloy coatings electrodeposited from a chloride bath using direct and pulse current 显示文摘 | Ashassi- Sorkhabi H Haqrah A Parvini- Ahmadi N | 2001 | Surface and Coatings Technology2001，140，： | 1 |
| 3 | Dispersion and deposition of spherical particles from point sources in a turbulent channel flow 显示文摘 | Li A Ahmadi G | 1992 | Aerosol Science and Technology1992，，16： | 1 |
| 4 | Shape-controlled synthesis of colloidal platinum nanoparticles显示文摘 | Ahmadi T S Wang Z L Henglein A | 1996 | Science1996，272，： | 1 |
| 5 | Shape - controlled synthesis of colloidal platinum nanoparticles 显示文摘 | T S Ahmadi Z L Wang T C Green A Henglein M A El- Sayed | 1996 | Science1996，272，： | 1 |
| 6 | Illumination InvariantFeature Extraction and Mutual--Information-based LocalMatching for Face Recognition Under Illumination Variation andOcclusion显示文摘 | Nabatchian A Esam A R Ahmadi M | 2011 | Pattern Recognition2011，44，10： | 1 |
| 7 | The effects of Continuous Care Model on depression, anxiety, and stress in patients on hemodialysis 显示文摘 | Rahimi A Ahmadi F Gholyaf M | 2008 | Nephrol Nurs J2008，35，1： | 1 |
| 8 | Cepsrum-based pitch detection using a new statistical V/UV classification algorithm 显示文摘 | Ahmadi S Spanias A S | 1999 | IEEE Transactions on Speech and Audio Processing1999，7，3： | 1 |
| 9 | Dispersion and Deposition of Spherical Particles from Point Sources in a Turbulent Channel Flow显示文摘 | Li A Ahmadi D | | 0，，16： | 1 |
| 10 | Association between Ureaplasma urealyticum endocervical infection and spontaneous abortion显示文摘 | Ahmadi A Khodabandehloo M Ramazanzadeh R | 2014 | Iran J Microbiol2014，6，6： | 1 |
| 11 | A reliable Method for Recognition of Paper Currency by Approach to Local PCA 显示文摘 | Ahmadi A Omatu S Kosaka T | 2003 | Proceedings of the International Joint Conference on Neural Networks2003，，2： | 1 |
| 12 | Spatially-based model of land suitability analysis using Block Kriging显示文摘 | Keshavarzi A Sarmadian F Ahmadi A | 2011 | Australian Journal of Crop Science2011，5，12： | 1 |
| 13 | The value of transcranial Doppler derived pulsatility index for diagnosing cerebral small-vessel disease显示文摘 | Ghorbani A Ahmadi MJ Shemshaki H | 2015 | Adv Biomed Res2015，4，： | 1 |
| 14 | Using natural zeolite for the improvement of soil salinity and crop yield显示文摘 | NOORI M ZENDEHDEL M AHMADI A | 2006 | Toxicological&Environmental Chemistry2006，88，1： | 1 |
| 15 | Pattern recognition with moment invariants:a comparative study and new results显示文摘 | Belkasim S O Shridhar M Ahmadi A | 1991 | Pattern Recognition1991，24，： | 1 |
| 16 | Effect of geometrical parameters on SCF distribution along the weld toe of tubular KT-joints under balanced axial loads显示文摘 | LOTFOLLAHI-YAGHIN M A AHMADI H | 2010 | International Journal of Fatigue2010，32，14： | 1 |
| 17 | The effects of milk thistle-extract (Silybum mariamum) as medical herbal on non-specific immune system of rainbow trout (Oncorhynchus mykiss) 显示文摘 | Ahmadi K Vosoughi Abdolrahim M A Ataee M B | 2010 | Mar Biol2010，2，7： | 1 |
| 18 | Sublayer model for turbulent deposition of particles in vertical ducts with smooth and rough surfaces显示文摘 | FAN F G AHMADI G A | 1993 | Journal of Aerosol Science1993，24，： | 1 |
| 19 | Can fresh embryo transfers be replaced by cryopreserved-thrawed embryo transfers in assisted reproductive cycles? A randomized controlled trial 显示文摘 | Aflatoonian A Oskouian H Ahmadi S | 2010 | Assist Reprod Genet2010，27，3： | 1 |
| 20 | Adaptive vehicle lateral-plane motion control using optimal tire friction forces with saturation limits consideration显示文摘 | AHMADI J SEDIGH A K KABGANIAN M | 2009 | IEEE Transactions on Vehicular Technology2009，58，8： | 1 |
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