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| 1 | Mammary gland growth and vascularity at parturition and during lactation in primiparous ewes fed differing levels of selenium and nutritional plane during gestation显示文摘Background: Objectives were to examine the effects of selenium(Se) supply and maternal nutritional plane during gestation on mammary gland growth, cellular proliferation, and vascularity at parturition and d 20 of lactation. Rambouillet primiparous ewes(n = 84) were allocated to treatments in a 2 x 3 factorial. Factors were dietary Se(adequate Se [ASe, 11.5 μg/kg BW] or high Se [HSe, 77.0 μg/kg BW]) and nutritional plane(60% [RES], 100% [CON], or 140% [EXC]). At parturition, lambs were removed and 42 ewes(7/treatment) were necropsied. Remaining ewes were fed a common diet meeting requirements for lactation and mechanically milked twice daily until necropsy on d 20. At both necropsy periods, mammary glands were dissected and tissues harvested. Samples were analyzed for RNA, DNA, and protein content, cell proliferation, and vascularity. Where interactions were present(P ≤ 0.05), least squares means from the highest-order interaction are presented. Results: Final body weight of ewes was least(P ≤ 0.002) in RES, intermediate for CON, and greatest for EXC, regardless of stage of the ewe at necropsy(parturition or d 20 of lactation). In ewes necropsied at parturition, mammary glands were heavier(P = 0.02) in EXC compared to RES, with CON intermediate. Concentration of RNA(mg/g) was decreased(P = 0.01) in EXC compared to CON at parturition. There was a tendency(P = 0.07) for a Se by nutrition interaction in percentage of cells proliferating where ASe-EXC ewes had greater(P ≤ 0.02) number of proliferating cells then all other treatments. Mammary vascular area tended(P = 0.08) to be affected by a Se by nutrition interaction where ASe-CON had less(P = 0.007) vascular area than HSe-CON ewes. In ewes necropsied at d 20 of lactation, the number of alveoli per area was decreased(P ≤ 0.05) in RES compared to CON and EXC-fed ewes. Conclusions: Results of this study indicate that proper maternal nutritional plane during gestation is important for mammary gland development, even out to d 20 of lactation. | Tammi L Neville Allison M Meyer Arshi Reyaz Pawel B Borowicz Dale A Redmer Lawrence P Reynolds Joel S Caton Kimberly A Vonnahme | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 3 |
| 2 | Radiometric correction of visible and infrared remote sensing data at the Canada Centre for Remote Sensing显示文摘 | AHERN F J Brown R J Cihlar J Gauthier R Murphy J Neville R A and Teillet P M | 1984 | International Journal of Remote Sensing1984，8，： | 2 |
| 3 | Methylation of TIMP3 in esophageal squamous cell carcinoma显示文摘AIM: To measure the frequency of DNA methylation of the tissue inhibitor of metalloproteinase 3 (TIMP3) promoter and relate this to any change of gene expression in esophageal squamous cell carcinoma in patients from a region of high incidence in China.METHODS: Cancer cell lines were treated with or without the demethylating reagent 5-aza-2’-deoxycytidine. Methylation of the TIMP3 promoter was assessed in three regions by melt curve analysis and its expression was assessed by real-time RT-PCR. Tumors and proximal resection margins were obtained from 64 patients with esophageal squamous cell carcinoma from a region of high incidence in China. Methylation was assessed by melt curve analysis and expression by immunohistochemistry.RESULTS: Methylation in one of the three promoter regions assessed correlated with gene silencing in esophageal cell lines. A degree of methylation of TIMP3 was found in only four esophageal squamous cell carcinomas, and partial loss of TIMP3 protein expression in just one.CONCLUSION: Methylation and loss of expression of TIMP3 occurs infrequently in esophageal squamous cell carcinoma in a region of high incidence in China. | Eric Smith Neville J De Young Zi-Qiang Tian Maria Caruso Andrew R Ruszkiewicz Jun-Feng Liu Glyn G Jamieson Paul A Drew | 2008 | World Journal of Gastroenterology2008，14，2： | 2 |
| 4 | High performance concrete-- An overview显示文摘 | Neville A Aitcin P C | 1998 | Materials and Structures1998，31，3： | 2 |
| 5 | Integrated view of shrinkage deformation 显示文摘 | AITIN P C NEVILLE A ACKER P | 1997 | Concrete International1997，19，9： | 1 |
| 6 | An Integrated Methodology for Predicting Material Wear Rated Due to Erosion显示文摘 | Gnanavelu A Kapur N Neville A | 2009 | Wear2009，267，： | 1 |
| 7 | High performance concrete--An overview显示文摘 | Neville A Aitcin P C | 1998 | Materials and Structures1998，31，3： | 1 |
| 8 | Transformation range viscosity measurements using a Thermomehcnieal analyzer 显示文摘 | Neville M Sarofim A F | 1985 | Fuel1985，64，： | 1 |
| 9 | Effect of chemical surface heterogeneity on the adsorption mechanism of dissolved aromatics on activated carbon显示文摘 | Marcus Franz Hassan A Arafat Neville G Pinto | 2000 | Carbon2000，38，： | 1 |
| 10 | CO2 erosion-corrosion of pipeline steel (API X65) in oil and gas conditions-a systematic ap- proach显示文摘 | Hu Xinming Neville A | 2009 | Wear2009，267，11： | 1 |
| 11 | The Confused World of Sulfate Attack on Concrete显示文摘 | Neville A | 2004 | Cement and Concrete Research2004，34，8： | 1 |
| 12 | Composite Metal Foams Processed Through Powder Metallurgy 显示文摘 | Neville B P Rabiei A | 2008 | Materials and Design2008，29，： | 1 |
| 13 | CT characteristics of prim ary retroperitoneal neoplasms显示文摘 | Neville A Herts BR | 2004 | Crit Rev Comput Tomogr2004，45，4： | 1 |
| 14 | Erosion - corrosion behaviour of WC - based MMCs in liquid - solid slurries 显示文摘 | Neville A Reza F Chiovelli S | 2005 | Wear2005，259，16： | 1 |
| 15 | Non-Elastic Deformation of Concrete under Cyclic Compression 显示文摘 | Waley C P Neville A M | 1973 | Magazine of Concrete Research1973，25，84： | 1 |
| 16 | Spectral unmixing of hyperspectral imagery for mineral exploration显示文摘 | Neville R A Levesque J Staenz K | | 0，，： | 1 |
| 17 | 103 Testing for clopidogrel and aspirin anti-platelet activity in patients with acute coronary syndromes (ACS):should we test,and if so when显示文摘 | A P Worrall V Amoah A Nevill | | 0，，： | 1 |
| 18 | Adjusting ath- letes~body mass index to better reflect adiposity in epidemio- logical research显示文摘 | NEVILL A M WINTER E M WATTS A S | 2010 | J Sports Sci2010，28，： | 1 |
| 19 | Effects of plane of nutrition and selenium supply during gestation on ewe and neonatal offspring performance,body composition,and serum selenium显示文摘 | Meyer A M Reed J J Neville T L | 2010 | J Anita Sci2010，88，5： | 1 |
| 20 | Synthesis and characterization of a nano-structured sorbent for the direct removal of mercury vapor from flue gases by chelating 显示文摘 | Malyuba A Abu-Daabes Neville Pinto G | 2005 | Chemical Engineering Science2005，60，7： | 1 |
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