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| 1 | Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients显示文摘AIM To investigate the clinical utility of serum annexin A2(ANXA2) as a diagnostic marker for early hepatocellular carcinoma(HCC).METHODS This study was performed in HCC Clinic of Ain Shams University Hospitals, Cairo, Egypt and included: Group 1: Fifty patients with early stage HCC(Barcelona Clinic Liver Cancer stage A); Group 2: Twenty five patients with chronic liver disease; and Control Group: Fifteen healthy, age-and sex-matched subjects who were seronegative for viral hepatitis markers. The followinglaboratory investigations were done: Viral hepatitis markers [hepatitis B surface antigen and hepatitis C virus(HCV) antibodies], HCV RNA in HCV antibody-positive patients, serum alpha fetoprotein(AFP), and serum ANXA2 levels.RESULTS In this study, 88% of HCC patients(n = 44) were HCVpositive, while HBV infection represented only 8% of all HCC patients(n = 4); and two patients were negative for both viral markers. A highly significant difference was found between patients with HCC and chronic liver disease as well as controls with regard to serum ANXA2 levels(130, IQR 15-240; 15, IQR 15-17; and 17, IQR 15-30 ng/m L, respectively). The area under the curve of ANXA2 was 0.865; the cut-off value was established to be 18 ng/mL with a diagnostic sensitivity of 74% and a specificity of 88%, while the sensitivity and specificity of AFP at the cut-off value of 200 ng/dL were 20% and 100%, respectively.CONCLUSION Serum ANXA2 may serve as a biomarker for the early detection of HCC. | Mohamed K Shaker Hanzada I Abdel Fattah Ghada S Sabbour Iman F Montasser Sara M Abdelhakam Eman El Hadidy Rehab Yousry Ahmed K El Dorry | 2017 | World Journal of Hepatology2017，9，9： | 4 |
| 2 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 3 | Clomiphene citrate or letrozole for ovulation inductionin women with polycystic ovarian syndrome:a prospective randomized trial显示文摘 | Badawy A Abdel AM I Abulatta M | 2009 | Fertil Steril2009，92，3： | 1 |
| 4 | Harmonious graphs显示文摘 | SEOUD M ABDEL MAQSOUD A E I SHEEHAN J | 1995 | Utilitas Math1995，47，： | 1 |
| 5 | Aphid carboxylester- ases : Biochemical aspects and importance in the diagnosis of insecti- cide resistance显示文摘 | Abdel - Aal Y A I Wolff M A Roe R M | 1990 | Pestic Biochem Physiol1990，38，： | 1 |
| 6 | Tissue plasminogen activator and plasminogen activator inhibitor-1 levels in patients with acute myocardial infarction andunstable angina显示文摘 | Habib S Abdel G A Kurdi M I | 2012 | J Pak Med Assoc2012，62，7： | 1 |
| 7 | Enhancement of wear resistance of ductile cast iron by Ni-SiC composite coating显示文摘 | ABDEL A A KHALED M I ABDEL H Z | 2006 | Wear2006，260，910： | 1 |
| 8 | Characteristics of electrodeposition of Ni-polyethylene composite coatings 显示文摘 | ABDEL HAMID Z GHAYAD I M | 2002 | Materials Letters2002，53，45： | 1 |
| 9 | A new hybrid flower pollination algorithm for solving constrained global op- timization problems显示文摘 | ABDEL - RAOUF O ABDEL - BASET M E1 - HENAWY I | 2014 | International Journal of Applied Operational Research2014，4，2： | 1 |
| 10 | Analysis of Edge-detection Techniques for Crack Identification in Bridges显示文摘 | ABDEL QADER I ABUDAYYEH O KELLY M E | 2003 | Journal of Computing in Civil Engineering2003，17，4： | 1 |
| 11 | Clomiphene citrate or letrozole for ovulation inductionin patients with polycystic ovarian syndrome : a prospective randomized trial 显示文摘 | BADAWY A ABDEL AAL I ABULATTA M | 2009 | Fertility and Sterility2009，92，3： | 1 |
| 12 | Effect of alumina on ceramic properties of cordierite glass-ceramic from basalt rock显示文摘 | Salwa A M Abdel H Bakr I M | 2007 | Journal of the European Ceramic Society2007，27，23： | 1 |
| 13 | Role of silicate bacteria in releasing K and Si from bilite and orthoclase显示文摘 | ZAHRA M K ABDEL el-Al S I | 1980 | Soil Biology and Conservation of the Biosphere1980，，2： | 1 |
| 14 | Role of penile vascular insufficiency in erectile dysfunction in renal transplant recipients 显示文摘 | Eraky I A Fouda M A | 2002 | Int J Impot Res2002，14，1： | 1 |
| 15 | Comparative toxicity of Croton macrostachys,Jatropha curcas and Piper abyssinica seeds in Nubian goats显示文摘 | ABDEL GADIR W S ONSA T O ALI W E M El BADWI S M A ADAM S E I | 2003 | Small Ruminant Res2003，48，： | 1 |
| 16 | Clomiphene citrate or letrozole for ovulation induction in women with polycystic ovarian syndrome:a prospective randomized trial显示文摘 | Badawy A Abdelal I Abulatta M | | 0，，03： | 1 |
| 17 | Hydrogeochemis?try processes controlling the water chemistry of a closed saline lake locat?ed in Sahara Desert: Lake Qarun, Egypt显示文摘 | Abdel Wahed M S Mohamed E A Ei-Sayed M I | 2015 | Aquat Geochem2015，21，： | 1 |
| 18 | Harmonious Graphs显示文摘 | Seoud M Abdel Maqsoud A E I Sheehan J | 1995 | Util Math1995，47，： | 1 |
| 19 | Effect of admixtures on the electrical behaviour of portland cement 显示文摘 | ABDEL W M G HELMY I M EL DIDAMONY H | 1993 | J Mater Sci Lett1993，12，1： | 1 |
| 20 | Tissue plasminogen activator and plasminogen activator inhibitor-1 levels in patients with acute myocardial infarction and unstable angina显示文摘 | Habib SS Abdel Gader AG Kurdi M I | 2012 | J Pak Med Assoc2012，62，7： | 1 |
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