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| 1 | Randomized trial in malignant biliary obstruction:Plastic vs partially covered metal stents显示文摘AIM:To compare efficacy and complications of par-tially covered self-expandable metal stent(pcSEMS)to plastic stent(PS)in patients treated for malignant,infrahilar biliary obstruction.METHODS:Multicenter prospective randomized clinical trial with treatment allocation to a pcWallstent(SEMS)or a 10 French PS.Palliative patients aged≥18,for infrahilar malignant biliary obstruction and a Karnofsky performance scale index>60%from 6 participating North American university centers.Primary endpoint was time to stent failure,with secondary outcomes of death,adverse events,Karnofsky performance score and short-form-36 scale administered on a three-monthly basis for up to 2 years.Survival analyses were performed for stent failure and death,with Cox proportional hazards regression models to determine significant predictive characteristics.RESULTS:Eighty-five patients were accrued over 37mo,42 were randomized to the SEMS group and 83patients were available for analyses.Time to stent failure was 385.3±52.5 d in the SEMS and 153.3±19.8 d in the PS group,P=0.006.Time to death did not differ between groups(192.3±23.4 d for SEMS vs211.5±28.0 d for PS,P=0.70).The only significant predictor was treatment allocation,relating to the time to stent failure(P=0.01).Amongst other measured outcomes,only cholangitis differed,being more common in the PS group(4.9%vs 24.5%,P=0.029).The small number of patients in follow-up limits longitudinal assessments of performance and quality of life.From an initially planned 120 patients,only 85 patients were recruited.CONCLUSION:Partially covered SEMS result in a longer duration till stent failure without increased complication rates,yet without accompanying measurable benefits in survival,performance,or quality of life. | Peter L Moses Khalid M AlNaamani Alan N Barkun Stuart R Gordon Roger D Mitty M Stanley Branch Thomas E Kowalski Myriam Martel Viviane Adam | 2013 | World Journal of Gastroenterology2013，19，46： | 6 |
| 2 | White matter hyperintensity progression is associated with incident probable dementia or mild cognitive impairment显示文摘Background White matter hyperintensity(WMH)on brain MRI is associated with developing dementia or mild cognitive impairment(MCI),but WMH progression over time has not been fully investigated as an independent risk factor.Methods We performed a post hoc analysis of the Systolic Blood Pressure Intervention Trial-Memory and Cognition in Decreased Hypertension(SPRINT MIND)trial.The primary outcome was incident probable dementia or MCI(dementia/MCI)before the follow-up MRI at 48 months from enrolment.The primary predictor was WMH progression,defined as the Z score difference between the follow-up and baseline WMH volumes.The secondary predictor was a binary WMH progression threshold(≥1.4 mL vs<1.4 mL).Results Among the 433 included patients,33(7.6%)developed dementia/MCI.There were 156(36.0%)patients who met the WMH progression threshold of≥1.4 mL,in whom the rate of dementia/MCI was 12.8%(20/156)vs 4.7%(13/277)of patients with<1.4 mL WMH progression(p=0.002).In multivariable logistic regression,the Z score of WMH progression was associated with dementia/MCI(OR 1.51,95%CI 1.12 to 2.04,p=0.007)as was the WMH progression threshold of≥1.4 mL(OR 2.89,95%CI 1.23 to 6.81,p=0.015).Conclusions In this post hoc analysis of SPRINT MIND,WMH progression over 48 months was associated with the development of probable dementia or MCI. | Adam de Havenon Kevin N Sheth Sharon D Yeatts Tanya N Turan Shyam Prabhakaran | 2022 | Stroke & Vascular Neurology2022，7，4： | 2 |
| 3 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 4 | Automatic ventricular cavity boundary detection from sequential ultrasound images using simulated annealing显示文摘 | Adam D | 1989 | IEEE Trans Med Imag1989，8，4： | 1 |
| 5 | 显示文摘 | HERBST D SMITH D ADAMS N G | 1989 | J Chem Soc Fraday Trans1989，285，10： | 1 |
| 6 | Rapid PCRbased identification of apple(Malus)cultivars and species显示文摘 | Mort on A Adams A N Barbara D J | 1993 | BCPC Monograph1993，54，： | 1 |
| 7 | Hydroch|orina tion of acetylene using carbon-supported gold cata- lysts:A study of catalyst reactivation显示文摘 | Bongani N Adams M D Neil ] C | 1991 | Journal of Catalysis1991，，37： | 1 |
| 8 | Effect of Poisson's ratio strains in adherends on stresses of an idealized lap joints显示文摘 | Adams R D Peppiatt N A | 1973 | J Strain Analysis1973，8，2： | 1 |
| 9 | 显示文摘 | SMITH D ADAMS N G | 1989 | J Chem Soc:Fraday Trans1989，285，10： | 1 |
| 10 | Streaming eovariance selection with applications to adaptive querying in sensor networks 显示文摘 | Anagnostopoulos C Adams N M Hand D J | 2010 | Computer Journal2010，53，9： | 1 |
| 11 | Effect of Poisson's ratio strains in adherends on stresses of an idealized lap joints显示文摘 | Adams R D Peppiatt N A | 1973 | The Journal of Strain Analysis1973，8，2： | 1 |
| 12 | Relations between the photoluminescence efficiency of CdTe nanocrystals and their surface properties revealed by synchrotron XPS显示文摘 | BORCHERT H TALAPIN D V GAPONIK N MCGINLEY C ADAM S LOBO A MOLLER T WELLER H | 2003 | J Phys Chem B2003，107，36： | 1 |
| 13 | Oxygen free radicals and parkinson disease显示文摘 | ADAMS J D ODUNZE I N | 1991 | Free Radical Biology and Medicine1991，10，： | 1 |
| 14 | 显示文摘 | Adams P N Apperley D C Monkman A P | 1993 | Polymer1993，34，2： | 1 |
| 15 | Coumarins from Cnidium monnieri and their antiosteoporotic activity显示文摘 | Zhang Q Qin L He W Van Puyvelde L Maes D Adams A Zheng H De Kimpe N | 2007 | Planta Med2007，73，1： | 1 |
| 16 | Computational Social Science显示文摘 | Lazer D Pentland A Adamic L Aral S Barabasi A L Brewer D Christakis N Contractor N Fowler J Gutmann M Jebara T King G Macy M Roy D Van Alstyne M | | 0，，5915： | 1 |
| 17 | Maturation matters: importance of maturation for antitumor immunity of dendritic cell vaccines显示文摘 | Adams S O' Neill D Bhardwaj N | 2004 | J Clin Oneol2004，22，18： | 1 |
| 18 | Blended learning in education: effects on knowledge and attitude 显示文摘 | Ireland J Johnson N Adams D | 2009 | Br J Nurs2009，18，2： | 1 |
| 19 | The dynamic properties of carbon-glass fiber sandwich laminated composites,Theoretical,experimental and economic consideration显示文摘 | Ni R G Lin D N Adams R D | 1984 | Composites1984，15，4： | 1 |
| 20 | Langmuir显示文摘 | Glaser N Adams D J B ker A Glaser N Adams D J Boker A Krausch G | 2006 | 22:5 2272006，22，： | 1 |
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