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| 1 | Randomized trial in malignant biliary obstruction:Plastic vs partially covered metal stents显示文摘AIM:To compare efficacy and complications of par-tially covered self-expandable metal stent(pcSEMS)to plastic stent(PS)in patients treated for malignant,infrahilar biliary obstruction.METHODS:Multicenter prospective randomized clinical trial with treatment allocation to a pcWallstent(SEMS)or a 10 French PS.Palliative patients aged≥18,for infrahilar malignant biliary obstruction and a Karnofsky performance scale index>60%from 6 participating North American university centers.Primary endpoint was time to stent failure,with secondary outcomes of death,adverse events,Karnofsky performance score and short-form-36 scale administered on a three-monthly basis for up to 2 years.Survival analyses were performed for stent failure and death,with Cox proportional hazards regression models to determine significant predictive characteristics.RESULTS:Eighty-five patients were accrued over 37mo,42 were randomized to the SEMS group and 83patients were available for analyses.Time to stent failure was 385.3±52.5 d in the SEMS and 153.3±19.8 d in the PS group,P=0.006.Time to death did not differ between groups(192.3±23.4 d for SEMS vs211.5±28.0 d for PS,P=0.70).The only significant predictor was treatment allocation,relating to the time to stent failure(P=0.01).Amongst other measured outcomes,only cholangitis differed,being more common in the PS group(4.9%vs 24.5%,P=0.029).The small number of patients in follow-up limits longitudinal assessments of performance and quality of life.From an initially planned 120 patients,only 85 patients were recruited.CONCLUSION:Partially covered SEMS result in a longer duration till stent failure without increased complication rates,yet without accompanying measurable benefits in survival,performance,or quality of life. | Peter L Moses Khalid M AlNaamani Alan N Barkun Stuart R Gordon Roger D Mitty M Stanley Branch Thomas E Kowalski Myriam Martel Viviane Adam | 2013 | World Journal of Gastroenterology2013，19，46： | 6 |
| 2 | Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation. | Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes | 2016 | World Journal of Diabetes2016，7，2： | 4 |
| 3 | The location of defects in structures from measurements of natural frequencies显示文摘 | Cawley P Adams R D | | 0，，02： | 2 |
| 4 | A frequency domain method for estimating the parameters of a non-linear structural dynamic model through feedback显示文摘 | D E Adams R J Allemang | 2000 | Mechanical Systems and Signal Processing2000，14，4： | 1 |
| 5 | The Giardia Lamblia genome显示文摘 | Adam R D | 2000 | Int J Parasitol2000，30，： | 1 |
| 6 | Liver resection as a bridge to transplantation for hepatocellular carcinoma on cirrhosis: a reasonable strategy? 显示文摘 | Adam R Azoulay D Castaing D | 2003 | Ann Surg2003，238，4： | 1 |
| 7 | Heart disease and stroke statistics-2010 update:a report from the American Heart Association显示文摘 | WRITING GROUP MEMBERS Lloyd-Jones D Adams R J | 2010 | Circulation2010，121，7： | 1 |
| 8 | The environmental fate of phthalate esters: a literature review显示文摘 | Stales C A Peterson D R Parkerton T F Adams W J | 1997 | Chemosphere1997，35，4： | 1 |
| 9 | Damping in advanced polymer-matrix composites显示文摘 | Adams R D Mahefi M R | 2003 | Journal of Alloys Compounds2003，355，1： | 1 |
| 10 | Liver resection as a bridge to transplantation for hepatocellular catcinoma on cirrhosis:a reasonable strategy?显示文摘 | Adam R Azoulay D Castaing D | 2003 | Ann Surg2003，238，4： | 1 |
| 11 | A Vibration Technique for Non-Destructively Assessing the Integrity of Structures显示文摘 | Adams R D Cawley P Pye C J | 1978 | Journal of Mechanical Engineering Science1978，，20： | 1 |
| 12 | Central pontinemyelinolysis: a hitherto undescribed disease occurring in alcoholic and malnourished patients 显示文摘 | Adams R D Victor M Mancall E L | 1959 | AMA Arch Neurol Psychiatry1959，81，4： | 1 |
| 13 | Intratumoral de-livery of boronated epidermal growth factor for neutron cap-ture therapy of brain tumors显示文摘 | Yang W Barth R F Adams D M | 1997 | Carcer Res1997，57，19： | 1 |
| 14 | Heart diseae and stroke statistics-2010 update: a report from the American Heart Association显示文摘 | Lloyd-Jones D Adams R J Brown TM | 2010 | Circulation2010，121，7： | 1 |
| 15 | Heart dis- ease and stroke statistics-2009 update:a report from the a- merican heart association statistics committee and stroke statistics subcommitt-ee 显示文摘 | Lloyd-Jones D Adams R Camethon M | 2009 | Circulation2009，119，3： | 1 |
| 16 | Effect of Poisson's ratio strains in adherends on stresses of an idealized lap joints显示文摘 | Adams R D Peppiatt N A | 1973 | J Strain Analysis1973，8，2： | 1 |
| 17 | Use of High-pressure Processing for Oyster Shucking and Shelf-life Extension 显示文摘 | lie H Adams R M Farkas D F | 2002 | Journal of Food Science2002，67，2： | 1 |
| 18 | Heart disease and stroke statistics-2010 update A report from the American Heart Association显示文摘 | Lloyd-Jones D Adams R J Brown TM | 2010 | Circulation2010，121，： | 1 |
| 19 | The environmental fate of phthalate esters: a literature review 显示文摘 | Stales C A Peterson D R Parkerton T F Adams W J | 1997 | Chemosphere1997，35，4： | 1 |
| 20 | Effect of fibre orientation and laminate geometry on the dynamic properties of CFRP显示文摘 | Adams R D Bacon D G C | 1973 | Journal of composite naaterials1973，7，4： | 1 |
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