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| 1 | Research advances on the multiple uses of Moringa oleifera: a sustainable alternative for socially neglected population显示文摘Moringa oleifera Lam(Moringaceae) is a plant with high nutritional and medicinal value. Native to India, it is now widely distributed throughout tropical and subtropical regions of the world. Its different parts are sources of proteins, vitamins and minerals and present different pharmacological and biotechnological potential. Moreover, M. oleifera seeds are widely used in water and effluent treatment, for their coagulation, flocculation and sedimentation properties, their ability of improving water quality, by reducing organic matter and microbial load, with special applicability in intensive animal production systems, such as aquaculture. In addition, due to its high nutritional value and several medicinal properties, this tree may act as a nutritional and medical alternative for socially neglected populations. In this context, this review gathers information on M. oleifera, emphasizing its chemical constituents, nutritional, pharmacological and antimicrobial properties, applications in the treatment of water effluents, and ecological and social aspects. | Raimunda Samia Nogueira Brilhante Jamille Alencar Sales Vandbergue Santos Pereira Débora de Souza Collares Maia Castelo-Branco Rossana de Aguiar Cordeiro Célia Maria de Souza Sampaio Manoel de Araújo Neto Paiva Joao Bosco Feitosa dos Santos JoséJúlio CostaSidrim Marcos Fábio Gadelha Rocha | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，7： | 10 |
| 2 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 3 | Analysis of the SDHD gene, the susceptibility gene for familial paraganglioma syndrome (PGL1),in pheochromocytomas显示文摘 | Aguiar R C Cox G Pomeroy S L | 2001 | J Clin Endocrinol Metab2001，86，6： | 1 |
| 4 | TIMI,PURSUIT,and GRACE risk scores:sustained prognostic value and interaction with revascularization in NSTE-ACS显示文摘 | de Araujo Goncalves P Ferreira J Aguiar C | | 0，，09： | 1 |
| 5 | Performance capture from sparse multi-view video 显示文摘 | de Aguiar E Stoll C Theobalt C | 2008 | ACM Transactions on Graphics2008，27，3： | 1 |
| 6 | Video-based reconstruction of animatable human characters 显示文摘 | Stoll C Gall J De Aguiar E | 2010 | ACM Transactions on Gra- phics(TOG)2010，29，6： | 1 |
| 7 | A systems approach for the estimation of the effects of land consolidation projects (LCPs) :a model and its application 显示文摘 | CASTRO C J AGUIAR P P MIRA D S L | 2001 | Agricultural Systems2001，68，3： | 1 |
| 8 | Physicochemical studies on the interaction between N - Decanoyl - N - methylglucamide and bovine serum albumin 显示文摘 | RUIZ C C HIERREZUELO J M AGUIAR J | 2007 | Biomacromolecules2007，8，8： | 1 |
| 9 | Prognostic value of cardiac troponin release kinetics in unstable angina 显示文摘 | Teles R Ferreira J Aguiar C | 2000 | Rev Port Cardiol2000，19，4： | 1 |
| 10 | Short-Term Load Forecasting for Microgrids Based on Artificial Neural Networks显示文摘 | HERNANDEZ L BALADRON C AGUIAR J M | 2013 | Energies2013，6，3： | 1 |
| 11 | Friedel-Crafts acylaiton of anisole with acetic anhydride over silica-supported hetempolyphostungstic acid (HPW/SiO2 )显示文摘 | CARDOSO L A M ALVES W It GONZAGA A R E AGUIAR L M G ANDRADE H M C | 2004 | J Mol Catal A2004，209，12： | 1 |
| 12 | Internal suture technique for improving projection and stability in secondary gluteoplasty显示文摘 | JAIMOVICH C A ALMEIDA M W AGUIAR L F | 2010 | Aesthet Surg J2010，30，3： | 1 |
| 13 | Best cases from the AFIP:congenital intracranial teratoma显示文摘 | SANDOW B A DORY C E AGUIAR M A | 2004 | Radiographics2004，24，4： | 1 |
| 14 | Nuclear inosi- tol 1,4,5-trisphosphate is a necessary and conserved sig- nal for the induction of both pathological and physiological cardiomyocyte hypertrophy 显示文摘 | Arantes LA Aguiar C J Amaya M J | 2012 | J Mol Cell Cardiol2012，53，4： | 1 |
| 15 | Antimalarial activity and mechanisms of action of two novel 4- aminoquinolines against chloroquine-resistant parasites 显示文摘 | AGUIAR A C C SANTOS R D M FIGUEIREDO F J B | 2012 | PLoS One2012，7，37： | 1 |
| 16 | Temperature Dependence of the Viscoelastic Response of In, Sn and In -Sn Alloys 显示文摘 | Hermida E B Melo D G Aguiar J C | 2000 | Journal of Alloys and Compounds2000，310，1： | 1 |
| 17 | Microwave Promoted Suzuki Reactions between Aroyl Chlorides and Boronic Acids Catalyzed by Het- erogeneous and Homogeneous Phosphine-free Palla- dium Catalysts 显示文摘 | DANIELA DE L M AGUIAR L C ANTUNES O A | 2011 | J of Organomet Chem2011，696，1516： | 1 |
| 18 | Chemical modification of cross-linked resinbased on acrylonitrile for anchoring metal ions 显示文摘 | de Santa Maria L C Amorim M C V Aguiar M R M P | 2001 | Reactive and Functional Polymers2001，49，2： | 1 |
| 19 | Impact of ESC/ACCF/ AHA/WHF universal definition of myocardial infarction on mortality at 10 years显示文摘 | Costa FM Ferreira J Aguiar C | 2012 | Eur Heart J2012，33，： | 1 |
| 20 | How the modified Clinical Pulmonary Infection Score can identify treatment failure and avoid overusing antibiotics in ventilator-associated pneumonia显示文摘 | da SPS de Aguiar V E Fonseca M C | 2014 | Acta Paediatr2014，103，9： | 1 |
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