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| 1 | Non-invasive splenic parameters of portal hypertension:Assessment and utility显示文摘BACKGROUND Portal hypertension is a major complication of cirrhosis that is associated with significant morbidity and mortality.The present gold-standard method to risk stratify and observe cirrhosis patients with portal hypertension is hepatic venous pressure gradient measurement or esophagogastroduodenoscopy.However,these methods are invasive,carry a risk of complications and are associated with significant patient discomfort.Therefore,non-invasive splenic parameters are of clinical interest as potential useful markers in determining the presence of portal hypertension.However,diagnostic accuracy and reproducibility remains unvalidated.AIM To assess the diagnostic accuracy of spleen stiffness,area and diameter in predicting the presence of portal hypertension.METHODS Of 50 patients with varying liver disease pathologies were prospectively recruited from the St.Mary’s Hospital Liver Unit in London;25 with evidence of portal hypertension and 25 with no evidence of portal hypertension.Liver stiffness,spleen stiffness,spleen diameter and spleen area were measured using the Philips Affiniti 70 elastography point quantification point shear wave elastography system.The aspartate aminotransferase-to-platelet-ratio-index(APRI)score was also calculated.Performance measures,univariate and multivariate logistic regression were used to evaluate demographic,clinical and elastography variables.Interclass correlation coefficient was used to determine the reproducibility of splenic area and diameter.RESULTS On univariate and individual performance,platelet count[area under the receiver operating characteristic(AUROC)0.846,P value<0.001],spleen area(AUROC 0.828,P value=0.002)and APRI score(AUROC 0.827,P value<0.001)were the most accurate variables in identifying the presence of portal hypertension.On multivariate logistic regression models constructed,the combination of spleen area greater than 57.90 cm2 and platelet count less than 126×10^9 had 63.2%sensitivity and 100%specificity,100%positive predictive value and 100%negative predictive value.An alternative combination of spleen stiffness greater than 29.99 kPa and platelet count less than 126×10^9 had 88%sensitivity,75%specificity,78.6%positive predictive value and 85.7%negative predictive value.An interclass correlation coefficient value of 0.98(95%CI:0.94-0.99,P value<0.001)and 0.96(95%CI:0.91-0.99,P value<0.001)were determined for inter-operator variability for spleen area and diameter respectively.CONCLUSION Spleen area,spleen stiffness and platelet count may be useful markers to assess the presence of portal hypertension in patients of various etiologies. | Ayesha Karim Ahmad Sebastiana Atzori James Maurice Simon D Taylor-Robinson Adrian KP Lim | 2020 | World Journal of Hepatology2020，12，11： | 2 |
| 2 | Acute ischaemic stroke interventions: large vessel occlusion and beyond显示文摘Care for acute ischaemic stroke is one of the most rapidly evolving fields due to the robust outcomes achieved by mechanical thrombectomy.Large vessel occlusion(LVO)accounts for up to 38%of acute ischaemic stroke and comes with devastating outcomes for patients,families and society in the pre-intervention era.A paradigm shift and a breakthrough brought mechanical thrombectomy back into the spotlight for acute ischaemic stroke;this was because five randomised controlled trials from several countries concluded that mechanical thrombectomy for acute stroke offered overwhelming benefits.This review article will present a comprehensive overview of LVO management,techniques and devices used,and the future of stroke therapy.In addition,we review our institution experience of mechanical thrombectomy for posterior and distal circulation occlusion. | Ahmad Sweid Batoul Hammoud Sunidhi Ramesh Daniella Wong Tyler D Alexander Joshua Harrison Weinberg Maureen Deprince Jaime Dougherty Dimitri Jean-Mickael Maamari Stavropoula Tjoumakaris Hekmat Zarzour Michael R Gooch Nabeel Herial Victor Romo David M Hasan Robert H Rosenwasser Pascal Jabbour | 2020 | Stroke & Vascular Neurology2020，5，1： | 2 |
| 3 | Subcloning of bph genes from Pseudomonas testosteroni B-356 in Pseudomonsa putida and Escherichia coli : Evidence for dehalogenation during initial attack on chlorobiphenyls 显示文摘 | Ahmad D Sylvestre M Sondossi M | 1991 | Applied and Environmental Microbiology1991，57，10： | 1 |
| 4 | Hydrolysis and precipitation ofpolyacrylamides in hard brines at elevated temperature显示文摘 | Ahmad M A Peter H D | 1987 | Soc Petrol Engrs Reservoir Eng1987，，5： | 1 |
| 5 | RAPDanalysis of Fusarium isolates causing Mango Malformation disease inPakistan显示文摘 | ZAFAR I MEHBOOB R ALTAF D AHMAD S YUSUF Z | 2006 | World Journal Microbiology and Biotechnology2006，22，11： | 1 |
| 6 | Seasonal variations in the semen quality of young British goats显示文摘 | Ahmad N Noakes D E | 1996 | British Veterinary Journal1996，152，2： | 1 |
| 7 | Age-related cataract显示文摘 | Asbell PA Dualan I Mindel J Brocks D Ahmad M Epstein S etal | 2005 | Lancet2005，365，9459： | 1 |
| 8 | Apoptosis in fresh and cryopr- eserved Buffalo sperm 显示文摘 | Khan D R Ahmad N Anzar M | 2009 | Theriogenology2009，71，5： | 1 |
| 9 | Inflammation : the link between insulin resistance, obesity and diabetes 显示文摘 | Paresh D Ahmad A Arindam B | 2004 | Trends Immunol2004，25，： | 1 |
| 10 | ERCP core curriculum显示文摘 | Chutkan R K Ahmad A S Cohen J Cruz-Correa M R Desilets D J Dominitz J A ERCP Core Curriculum prepared by the ASGE Training Committee | 2006 | Gastrointest Endosc2006，63，： | 1 |
| 11 | Creep behavior of epoxy-based adhesive reinforced with nanoparticles for bonded-in timber connection显示文摘 | Ahmad Z Ansell M Smedley D | 2012 | Journal of Materials in Civil Engineering2012，24，7： | 1 |
| 12 | Effects of probiotics, prebiotics, and synbiotics on messenger RNA expression of caveolin-1, NOS, and genes regulating oxidative stress in the terminal ileum of formula-fed neonatal rats 显示文摘 | D'Souza A Fordjour L Ahmad A | 2010 | Pediatr Res2010，67，5： | 1 |
| 13 | Region-based rate control and bit allocation for wireless video transmission显示文摘 | SUN Y AHMAD I Li D D | 2006 | IEEE Transactions on Multimedia2006，8，1： | 1 |
| 14 | Variable step size P&O MPPT algorithm for PV systems显示文摘 | AHMAD A D CONSTANTIMOS S | 2006 | Communications and Information Technologies2006，，6： | 1 |
| 15 | Functional analysis oftumour necrosis factor-alpha-related apoptosis-inducing1igand(TRAIL):cysteine-230plays a critical ro1ein the ho-motrimerization and biological activity of this novel tumoricid-al cytokine显示文摘 | Trabzuni D Famulski KS Ahmad M | 2000 | Biochem J2000，350，： | 1 |
| 16 | A CCD-based fluorescence imaging system for real-time loop-mediated isothermal amplificationbased rapid and sensitive detection of waterborne pathogens on microchips显示文摘 | AHMAD F SEYRIG G TOURLOUSSE D M | 2011 | Biomed Microdevices2011，13，5： | 1 |
| 17 | Occurrence ofbisphenol A in surface water, drinking water and plamm from Malaysia with exposure assessment from consumption of drinking water显示文摘 | Santhi V A Sakai N Ahmad E D | 2012 | Science of The Total Environmen2012，427，： | 1 |
| 18 | Seasonal variations in testis size,libido and plasma testosterone concentrations in British goats显示文摘 | Ahmad N Noakes D E | 1995 | Animal Science1995，61，3： | 1 |
| 19 | Hypercalcemic Crisis : A Clin- ical Review显示文摘 | Ahmad S Kuraganti G Steenkamp D | 2015 | Am J Med2015，128，3： | 1 |
| 20 | FoxMl down-regulation leads to inhibition of proliferation, migration and invasion of breast cancer cells through the modulation of extra-cellular matrix degrading factors 显示文摘 | Ahmad A Wang Z Kong D | 2010 | Breast Cancer Res Treat2010，122，2： | 1 |
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