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| 1 | Efficacy and safety of treatment of hepatitis C virus infection in renal transplant recipients显示文摘AIM: To assess the efficacy and safety of combinedpegylated interferon and ribavirin therapy in hepatitis C virus (HCV) infection in renal transplant recipients. METHODS: This is a retrospective chart review of post renal transplant patients who were positive for anti-HCV and HCV-RNA, and who have received treatment with combination of pegylated interferon and ribavirin between October 2003 and December 2008. Only patients with stable graft function and absence of evidence of cirrhosis and who received the therapy for continuous 48 wk were included. Nineteen patients (13 male and 6 female) were identified and included. The patient's complete blood count, liver and kidney prof ile, and cal- culated glomerular f iltration rate (GFR) were monitored every 6-8 wk while on treatment. HCV-RNA was tested at 12 wk for early virological response, at 48 wk for end of treatment response (ETR), and then retested at 24, and 48 wk after completion of therapy for sustained virological response (SVR). Liver biopsies were obtained before treatment from all patients and graft kidney biopsies were performed as required. RESULTS: Of the entire cohort, 9 patients (47.4%) showed an ETR and 8 had SVR (42.1%). Of the 8 patients with abnormal alanine aminotransferase (ALT) levels at baseline, 78.9% had their ALT normalized (including the virological non responders). ALT was normal in all responders at the end of therapy and at 24 wk post therapy (100%). Only one patient (5.3%) developed an increase in creatinine and decline in GFR from baseline towards the end of treatment. This patient's kidney biopsy revealed borderline rejection. There was no impact on response by HCV-genotype, initial HCV RNA load, age or sex of the patient or duration post transplant before commencement of therapy. All patients tolerated treatment in the same way as non-transplant with no unusual or increased occurrence of side effects. CONCLUSION: The combination of pegylated interferon and ribavirin is effective in suppressing HCV-RNA,with a low risk of graft rejection or failure in HCV infected renal transplant recipients. | Abdulrahman A Aljumah Mohamed A Saeed Ahmed I Al Flaiw Ibrahim H Al Traif Abduljaleel M Al Alwan Salem H Al Qurashi Ghormallah A Al Ghamdi Fayez F Al Hejaili Mohammed A Al Balwi Abdulla A Al Sayyari | 2012 | World Journal of Gastroenterology2012，18，1： | 2 |
| 2 | Elimination lf artifactal accumulation lf FDG in PET imaging of colorectal cancer显示文摘 | Miraldi F Vesselle H Faulhaber P er al | 1998 | Clin Nucl Med1998，23，： | 1 |
| 3 | Dental implant design and its relationship to long-term implant success 显示文摘 | Steigenga J T al Shammari K F Nociti F H | 2003 | Implant Dent2003，12，4： | 1 |
| 4 | High rate membranelessmicrobial electrolysis cell for continuous hydrogen production显示文摘 | Tartakovsky B Manuel M F Wang H ei al | 2009 | International Journal of Hydrogen Energy2009，34，2： | 1 |
| 5 | Research management team(RMT) : A model for research support -services at Duke Univelity显示文摘 | Snyder D C Epps S Berestbrd H F el al | 2012 | Clinical and Translational Science2012，5，6： | 1 |
| 6 | Thermal comfort in natu- rally ventilated buildings in hot - humid area of China 显示文摘 | Zhang Y F Wang J Y Chen H M el al | 2010 | Build- ing and Environment2010，45，11： | 1 |
| 7 | Thermostability and orange juice cloud destabilizing properties of multiple pectinesterases from orange显示文摘 | VersteegC Romouts F M Spitansen C H et al | 1980 | lournal of Food Science1980，45，4： | 1 |
| 8 | Enzymatic degumming of ramie bast fibers显示文摘 | BRUHLMANN F LEUPIN M ERISMANN K H et al | 2000 | Journal of Biotechnology2000，76，1： | 1 |
| 9 | Treatment with interferon-a2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques 显示文摘 | Falzarano D de Wit E Rasmussen AL Feldmann F Oku- mura A Scott DP Brining D Bushmaker T Martellaro C Baseler L Benecke AG Katze MG Munster VJ Feldma- nn H | 2013 | Nat Med2013，19，10： | 1 |
| 10 | Ultrafiltration mem-brane fouling by extracellular organic matters ( EOM) ofMicrocystis aeruginosa in stationary phase : Influences ofinterfacial characteristics of foulants and fouling mecha-nisms显示文摘 | Qu F S Liang H Wang Z Z ei al | 2012 | Water Res2012，46，5： | 1 |
| 11 | Iatrogenic cholesteatoma in children with OME in a training program显示文摘 | AL ANAZY F H | 2006 | Int J Pediatr Otorhinolaryngol2006，70，： | 1 |
| 12 | Uncertainty analysis of a spatial habitat suitability model and implications for ecological management of water bodies显示文摘 | Van der Lee G E M Van der Molen D T Van den Boogaard H F P et al | 2006 | Landsc Ecol2006，21，7： | 1 |
| 13 | Evaluation of the intergranular corrosion susceptibility of UNS S31803 duplex stainless steel with thermoelectric power measurements 显示文摘 | Ortiz N Curiel F F I opez V H el al | 2013 | Corrosion Science2013，69，： | 1 |
| 14 | Comparative study on joint data/pilot strategies for high sensitivity Galileo E1 open service signal acquisition 显示文摘 | TA T H DOVIS F MARGARIA D at al | 2010 | IET Radar Sonar & Navigation2010，4，6： | 1 |
| 15 | Stereotactic hypofractionated radiotherapy in stage I (T1-2NOMO) nonsmall-cell lung cancer (NSCLC) 显示文摘 | ZIMMERMANN F B GEINITZ H SCHILL S e t al | 2006 | Acta Oncol2006，45，： | 1 |
| 16 | The gut microbiota as an envi-ronmental factor that regulates fat storage显示文摘 | Backhed F Ding H Wang T ci al | 2004 | Proc Natl Acad SciU S A2004，101，15： | 1 |
| 17 | Independent determinants of the Tei index in hypertensive patients with preserved left ventricular systolic function显示文摘 | Masugata H Senda S Goda F et al | 2009 | Int Heart J2009，50，3： | 1 |
| 18 | Design and implementation of a framework for building distributed smart object systems显示文摘 | Kawsar F Nakajima T Park J H el al | 2010 | The Journal of Supercomputing2010，54，1： | 1 |
| 19 | Development of greatburdock essence compounds显示文摘 | Wang C H Chung F Y Tsai T R e/ al | 2012 | Genomic Medicine Biomarkers and Health Sciences2012，4，1： | 1 |
| 20 | An IterativeTwo-Terminal Fault-Location Method Based on UnsynchronizedPhasors显示文摘 | Dalcastagne A L rNoceti F ilho S Zurn H H e t al | 2008 | IEEE Transactions on Power Delivery : a Publication ofthe Power Engineering Society2008，23，4： | 1 |
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