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| 1 | Impact of concomitant use of proton pump inhibitors and clopidogrel or ticagrelor on clinical outcomes in patients with acute coronary syndrome显示文摘BackgroundThere 是在质子泵禁止者(PPI ) 和 clopidogrel 之间的可能的不利相互作用上的大争论。另外, PPI 的使用是否少些影响 ticagrelor 遗体的临床的功效,知道。在经皮的冠的干预(一种总线标准) .MethodsWe 回顾地从 “ 分析了数据以后,我们试图与急性冠的症候群(交流)在病人在临床的结果上决定 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响;真实 world” ;,国际,在 2003 和 2014 之间的多中心登记( n = 15,401 )并且在1年的合成主要端点上估计了 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响(所有原因死亡收到 PPI 的病人更老,更经常女性,并且是更可能的有 comorbidities。没有协会为收到 clopidogrel 的病人在 PPI 使用和主要端点之间被观察(调整 HR:1.036;95% CI:0.903-1.189 ) 或 ticagrelor (调整 HR:2.320;95% CI:0.875-6.151 )(P 相互作用 = 0.2004 ) 。同样, PPI 的使用没与所有原因死亡,重新梗塞,或与交流后面的一种总线标准的为与任何一个 clopidogrel 对待的病人或 ticagrelor.ConclusionsIn 病人的严重流血的减少的风险的增加的风险被联系, PPI 的伴随物使用没在收到 clopidogrel 或 ticagrelor 的病人与不利结果的增加的风险被联系。我们的调查结果显示与 clopidogrel 或 ticagrelor 在联合使用 PPI 是合理的,特别在有胃肠的流血的更高的风险的病人。 | Yan YAN Xiao WANG Jing-Yao FAN Shao-Ping NIE Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D'Ascenzo Jorge Saucedo Jose R Gonzfilez-Juanatey Stephen B Wilton Wouter J Kikkert Ivlin Nufiez-Gil Albert Ariza-Sole Xian-Tao SONG Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiril Sasko Kedev | 2016 | Journal of Geriatric Cardiology2016，13，3： | 12 |
| 2 | P2Y12受体抑制剂联合质子泵抑制剂对急性冠脉综合征患者缺血事件影响的临床分析显示文摘目的本研究旨在分析P2Y12受体抑制剂联合质子泵抑制剂(PPI)治疗对经皮冠状动脉介入(PCI)术后的急性冠脉综合征患者缺血事件的影响。方法基于国际多中心回顾性注册登记研究,纳入2003至2014年因急性冠脉综合征人院行PCI术的患者,分为PPI组及非PPI组并随访1年,主要临床终点为全因死亡/再发心肌梗死的复合终点。根据P2Y12受体抑制剂种类,将入组患者分为氯吡格雷组及替格瑞洛组,并比较不同药物与PPI联用发生临床终点事件的风险。结果研究入选9429例患者,PPI组占54.8%,具有更多高危因素。Cox回归结果提示PPI组较非PPI组全因死亡/再发心肌梗死复合事件的发生差异无统计学意义(HR1.00,95%CI 0.86—1.18)。根据P2Y12抑制剂种类不同分为氯吡格雷组和替格瑞洛组,不同P2Y12受体抑制剂联用PPI较未联用PPI患者的临床终点无差异,联用PPI的氯吡格雷组与替格瑞洛组的临床终点差异也无统计学意义。结论急性冠脉综合征患者PPI与P2Y12受体抑制剂联用不增加全因死亡和再发心肌梗死风险,尤其PPI联用氯吡格雷在患者的缺血事件上与替格瑞洛比较差异无统计学意义。 | 冯斯婷 严妍 范婧尧 王晓 郑文 聂绍平 Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D' Ascenzo Jorge Saucedo Jose R Conzalez-Juanatey Stephen B Wilton Wouter J Kikkert Ivan Nunez-Gil Albert Ariza-Sole Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiri Sasko Kedev | 2016 | 中华医学杂志2016，96，33： | 6 |
| 3 | Field N 2 O, CO 2 and CH 4 fluxes in relation to tillage, compaction and soil quality in Scotland显示文摘 | Bruce C Ball Albert Scott John P Parker | 1999 | Soil & Tillage Research1999，，1： | 2 |
| 4 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 5 | China, exploring critical success factors of partnering in construction projects 显示文摘 | Albert P C Dnaiel WM | 2004 | Journal of Construction Engineering and Management2004，，6： | 1 |
| 6 | A randomized phase II study of carboplatin and etoposide with or without pan-BCL-2 antagonist obatoclax in extensive-stage small cell lung cancer 显示文摘 | Langer C J Albert I Kovacs P | 2011 | J Clin Oncol2011，，： | 1 |
| 7 | Randomized phase fl study ofcarboplatin and etoposide with or without obatoclax mesylate inextensive-stage small cell lung cancer显示文摘 | Langer C Albert L Kovacs P | 2014 | Lung Cancer2014，85，42： | 1 |
| 8 | Compatibilizing effect of EPM-g-MA in EPDM/poly(trimethylene terephthalate) incompatible blends显示文摘 | ARAVIND I ALBERT P RANGANATHAIAH C | 2004 | Polymer2004，45，： | 1 |
| 9 | Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains 显示文摘 | ALBERTS P NILSSON C SELEN G | 2003 | Endocrinolo- gy2003，144，11： | 1 |
| 10 | Factors af- fecting the success of a construction project显示文摘 | ALBERT P C C DAVID S ADA P L C | 2004 | Jour- nal of Construction Engineering and Management2004，130，1： | 1 |
| 11 | Optimal Mainstream Traffic Flow Control of Large-scale Motorway Networks 显示文摘 | Rodrigo C C Ioarmis P Markos P Albert M | 2010 | Transportation Research Part C (S0968-090X)2010，18，2： | 1 |
| 12 | Reduced oxygen tension improves embryo quality but not clinical pregnancy rates:a randomized clinical study into ovum donation cycles 显示文摘 | de los Santos M J Gamiz P Albert C | 2013 | Fertil Steril2013，100，2： | 1 |
| 13 | Review of Studies on the Critical Success Factors for Public - Private Partnership (PPP) Projects from 1990 to 2013 显示文摘 | ROBERT O K ALBERT P C C | 2015 | International Journal of Project Management2015，33，6： | 1 |
| 14 | China, exploring critical success factors of partnering in construction projects 显示文摘 | Albert P C Dnaiel W M | 2004 | Journal of Construction Engineering and Management2004，，6： | 1 |
| 15 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
| 16 | Effect of high fat diet on KKAy and ob/ob mouse liver and adipose tissue corticosterone and 11-beta dehydrocorticosterone concentrations显示文摘 | Alberts P Ronquist-Nii Y Larsson C | 2005 | Horm Metab Res2005，37，7： | 1 |
| 17 | Intensive care adult patients with severe respiratory failure caused by influenza A(H1N1)v in Spain显示文摘 | Rello J Rodríguez A Ibaez P Socias L Cebrian J Marques A Guerrero J Ruiz-Santana S Marquez E Del Nogal-Saez F Alvarez-Lerma F Martínez S Ferrer M Avellanas M Granada R Maraví-Poma E Albert P SierraR Vidaur L Ortiz P Prieto del Portillo I Galván B León-Gil C H1N1SEMICYUC Working Group | 2009 | Crit Care2009，13，5： | 1 |
| 18 | Ganglioside GD3 sensitizes human hepato -ma cells to cancer therapy显示文摘 | Raquel P Albert M Olga C | 2002 | J Bio Chem2002，277，49： | 1 |
| 19 | Meseguer expression and enzymatic activity of the P450c17 gene in human adipose tissue显示文摘 | Marta J Albert C | 2002 | Eur J Endocrinol2002，，146： | 1 |
| 20 | Photonic crystal modeling using a tight-binding Wannier function method 显示文摘 | Albert J P Jouanin C Cassage D | 2002 | Opt Quantum Electron2002，34，13： | 1 |
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