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| 1 | Applicability of the PRECISE-DAPT score in elderly patients with myocardial infarction显示文摘Background Elderly patients with acute coronary syndromes(ACS)are at higher risk both for ischemic and bleeding complications.Current guidelines recommend the PRECISE-DAPT score for bleeding risk stratification in this setting,but no study assessed its applicability in elderly patients.This study aimed to assess the performance of the PRECISE-DAPT score in a series of non-selected elderly patients with ACS from routine clinical practice.Methods The IFFANIAM registry included prospectively patients aged>75 years with ST segment elevation myocardial infarction(STEMI).Main outcome measured was the incidence of relevant bleeding after discharge(bleeding leading to hospital readmission,need for transfusion,intervention,stop of antithrombotic drugs or death).Bleeding risk was classified:(A)according to PRECISE-DAPT values above or not the recommended cut-off point(>25);and(B)according to the quartiles of PRECISE-DAPT values observed in the IFFANIAM series(QI:<30;Q2:30-35;Q3:36-44;Q4:>45).Results A total of 208 patients were included.Mean age was 81.9±4.5 years.Most patients(92.6%)had a PRECISE-DAPT value>25.A total of 25 patients(12.0%)had bleeding events and 49 patients(23.6%)died.No significant differences regarding the incidence of bleeding were observed according to the recommended cutt of point>25.However,a progressive increase in the incidence of bleeding was observed across PRECISE-DAPT quartiles observed in this series(P=0.038).Conclusions The vast majority of elderly patients have PRECISE-DAPT values above the recommended cut-off point for bleeding risk.Using different cut-off points could be a more rational approach for predicting bleeding risk in these complex patients. | Albert Ariza-Sole Francesc Formiga Manuel Martinez-Selles Maria T Vidan Jaime Aboal | 2018 | Journal of Geriatric Cardiology2018，15，12： | 5 |
| 2 | Pyruvate-fortified resuscitation stabilizes cardiac electrical activity and energy metabolism during hypovolemia显示文摘AIM: To test the hypothesis that fluid resuscitation with Ringer's solution enriched with pyruvate(PR), a physiological antioxidant and energy substrate, affords protection of myocardial metabolism and electrophysiological performance superior to lactated Ringer's(LR) during hypovolemia and hindlimb ischemia-reperfusion.METHODS: Male domestic goats(25-30 kg) were exsanguinated to a mean arterial pressure of 48 ± 1 mm Hg. Right hindlimb ischemia was imposed for 90 min by applying a tourniquet and femoral crossclamp. LR or PR, infused iv, delivered 0.05 mmol/kg per minute L-lactate or pyruvate, respectively, from 30 min hindlimb ischemia until 30 min post-ischemia. Time controls(TC) underwent neither hemorrhage, hindlimb ischemia nor resuscitation. Goats were sacrificed and left ventricular myocardium biopsied at 90 min fluid resuscitation(n = 6 per group) or 3.5 h later(n = 9 LR, 10 PR, 8 TC).RESULTS: Myocardial 8-isoprostane content, phosphocreatine phosphorylation potential, creatine kinase activity, and heart rate-adjusted QT interval(QTc) vari- ability were evaluated at 90 min resuscitation and 3.5 h post-resuscitation. PR sharply lowered pro-arrhythmic QTc variability vs LR(P < 0.05); this effect persisted 3.5 h post-resuscitation. PR lowered myocardial 8-isoprostane content, a product of oxidative stress, by 39 and 37% during and 3.5 h after resuscitation, respectively, vs LR. Creatine kinase activity fell 42% post-LR vs TC(P < 0.05), but was stable post-PR(P < 0.02 vs post-LR). PR doubled phosphocreatine phosphorylation potential, a measure of ATP free energy state, vs TC and LR(P < 0.05); this energetic enhancement persisted 3.5 h post-resuscitation.CONCLUSION: By augmenting myocardial energy state and protecting creatine kinase activity, pyruvateenriched resuscitation stabilized cardiac electrical function during central hypovolemia and hindlimb ischemiareperfusion. | Hunaid A Gurji Daniel W White Besim Hoxha Jie Sun Albert H Olivencia-Yurvati Robert T Mallet | 2013 | World Journal of Critical Care Medicine2013，2，4： | 3 |
| 3 | Modeling cardiac arrest and resuscitation in the domestic pig显示文摘Cardiac arrest remains a leading cause of death and permanent disability worldwide. Although many victims are initially resuscitated, they often succumb to the extensive ischemia-reperfusion injury inflicted on the internal organs, especially the brain. Cardiac arrest initiates a complex cellular injury cascade encompassing reactive oxygen and nitrogen species, Ca2+ overload, ATP depletion, pro- and anti-apoptotic proteins, mitochondrial dysfunction, and neuronal glutamate excitotoxity, which injures and kills cells, compromises function of internal organs and ignites a destructive systemic inflammatory response. The sheer complexity and scope of this cascade challenges the development of experimental models of and effective treatments for cardiac arrest. Many experimental animal preparations have been developed to decipher the mechanisms of damage to vital internal organs following cardiac arrest and cardiopulmonary resuscitation(CPR), and to develop treatments to interrupt the lethal injury cascades. Porcine models of cardiac arrest and resuscitation offer several important advantages over other species, and outcomes in this large animal are readily translated to the clinical setting. This review summarizes porcine cardiac arrest-CPR models reported in the literature, describes clinically relevant phenomena observed during cardiac arrest and resuscitation in pigs, and discusses numerous methodological considerations in modeling cardiac arrest/CPR. Collectively, published reports show the domestic pig to be a suitable large animal model of cardiac arrest which is responsive to CPR, defibrillatory countershocks and medications, and yields extensive information to foster advances in clinical treatment of cardiac arrest. | Brandon H Cherry Anh Q Nguyen Roger A Hollrah Albert H Olivencia-Yurvati Robert T Mallet | 2015 | World Journal of Critical Care Medicine2015，4，1： | 2 |
| 4 | Kontrastmittelsonografie bei B-Bild-morphologisch unklaren Leberraumforderungen – Diagnostische Treffsicherheit im klinischen Alltag (DEGUM-Multicenter – Studie)显示文摘 | D Strobel K Seitz W Blank A Schuler C Dietrich A Herbay M Friedrich-Rust G Kunze D Becker U Will W Kratzer F Albert C Pachmann K Dirks H Strunk C Greis T Bernatik | 2008 | Ultraschall in Med2008，，05： | 2 |
| 5 | Large Molecular Hyperpolarizabilities. Quantitative Analysis of Aromaticity and Auxiliary Donor-Acceptor Effects显示文摘 | Albert I D L Marks T J Ratner M A | | 0，，： | 2 |
| 6 | Medical complications of surgical treatment of adult spinal deformity and how to avoid them显示文摘 | Baron E M Albert T J | 2006 | Spine2006，31，19： | 1 |
| 7 | Association of mineral metabolism factors with all-cause and cardiovascular mortality in hemodialysis patients:the Japan dialysis outcomes and practice patterns study显示文摘 | Kimata N Albert JM Akiba T | 2007 | Hemodial Int2007，11，4： | 1 |
| 8 | Sorption of polycyclic aromatic hydrocarbons and polychlorinated biphenyls to soot and soot-like materials in the aqueous environment:mechanistic considerations显示文摘 | Michiel T O Jonker Albert A | 2002 | Environ Sci Technol2002，36，17： | 1 |
| 9 | The biology of NKT cells 显示文摘 | Albert B Paul BS Luc T | 2007 | Annu Rev ImmunoL2007，25，： | 1 |
| 10 | Metal concentration in tissues of Sprtina alterniora and sediments of Geogia Salt Marshes显示文摘 | ALBERTS J J PRICE M T KANIA M | | 0，，： | 1 |
| 11 | Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy 显示文摘 | Risbud M V Albert T J Guttapalli A | 2004 | Spine2004，29，23： | 1 |
| 12 | Ambient UV-B radiation decreases photosynthesis in high arctic Vaccinium uliginosum 显示文摘 | ALBERT K R MIKKELSENB T N RO-POULSEN H | 2008 | Physiologia Plantarum2008，133，： | 1 |
| 13 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 14 | Snow physics as relevant to snow photochemistry 显示文摘 | Domine F Albert M Huthwelker T | 2008 | Atmos Chem Phys2008，8，2： | 1 |
| 15 | Consumption of a legume-enriched,low-glycemic index diet is associated with biomarkers of insulin resistance and inflammation among men at risk for colorectal Cancer 显示文摘 | Hartman T J Albert P S | 2010 | The Journal of Nutrition2010，140，： | 1 |
| 16 | Fiber,sex,and colorectal adenoma:results of a pooled analysis显示文摘 | JACOBS E T LANZA E ALBERTS D S | 2006 | Am J Clin Nutr2006，83，2： | 1 |
| 17 | Eff悬浮剂 ts of silymarin in alcoholic patient with cirrhosis of the liver: resuits of a controlled,doubled-blind randomized and multicenter trial 显示文摘 | Albert P Ramon P Miguel T | 1998 | Journal of Hepatology1998，28，： | 1 |
| 18 | Type 2 diabetes mel?litus and risk of incident atrial fibrillation in women显示文摘 | Schoen T Pradhan AD Albert CM | 2012 | J Am Coll Cardiol2012，60，15： | 1 |
| 19 | Posterior arthroscopic subtalar arthrodesis:ten cases at one-year follow-up显示文摘 | Albert A Deleu P A Leemrijse T | 2011 | Orthop Traumatol Surg Res2011，97，4： | 1 |
| 20 | Photosynthetic unit organization in a red alga:relationships between light-harvesting pigments and reaction centres显示文摘 | Alberte R S | 1983 | Plant Physiol1983，72，： | 1 |
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