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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 3 | Differential expression of apoptosis related proteins and nitric oxide synthases in Epstein Barr associated gastric carcinomas显示文摘瞄准:为了决定 Epstein Barr 的发生,病毒在巴西联系了胃的癌(GC ) 并且比较 apoptosis 的表情在 EBV 之间的相关蛋白质和氮的氧化物 synthases 积极、否定的胃的癌。方法:编码 EBV 的小 RNA-1 (EBER-1 ) 和 PCR 的原位杂交被执行在 GC 识别 EBV 的存在。Immunohistochemistry 被用来在 25 EBV 积极 GC 并且在 103 EBV 否定 GCS 识别 bcl-2, bcl-xl, bak, bax, p53, NOS-1, NOS-2,和 NOS-3 蛋白质的表情。结果:GC (25/208 ) 的 12% 盒子显示出 EBER-1 和 EBNA-1 表示。盒子是优先地 diffuse 打字与强烈淋巴在基质渗入。EBV 联系了 GC bcl-2 蛋白质的显示出的更高的表示和 bak 蛋白质的更低的表示与比在 EBV 否定 GC。确实, NOS-1 和 NOS-3 的表情经常在 EBV 被观察联系 GC。结论:我们的数据建议 EBV 感染可以保护肿瘤房间免受 apoptosis 的伤害,为永久房间骑车和增长给他们能力。另外, EBV 积极 GC 显示出能影响肿瘤前进和攻击性的组成的 NOS 的高表示。 | Maria D Begnami Andre L Montagnini Andre L Vettore Sueli Nonogaki Mariana Brait Alex Y Simoes-Sato Andrea Q A Seixas Fernando A Soares | 2006 | World Journal of Gastroenterology2006，12，31： | 5 |
| 4 | Understanding geophysical responses of shale-gas plays显示文摘 | ZHU Y P LIU E R ALEX M | 2011 | The Leading Edge2011，30，3： | 1 |
| 5 | The accuracy of management dividend forecasts in Australia显示文摘 | PHILIP B ALEX C JANICE C Y KADIR L | 2000 | Pacific- Basin finance journal2000，，8： | 1 |
| 6 | A Revised Weighted Sum Decision Model for Robot Selection显示文摘 | Goh C H Alex T Y C Cheng Chun-Hung | 1996 | Computers and Industrial Engineering1996，30，2： | 1 |
| 7 | Structural Reliability As- sessment Based on Probability and Convex Set Mixed Model显示文摘 | Luo Y J Kang Z Alex L | 2009 | Computers & Structures2009，87，： | 1 |
| 8 | X-ray diffractometric study of micro- crystallite size of naturally colored eottons显示文摘 | Chen H L Alex Y | 2000 | Journal of Applied Polymer Science2000，76，9： | 1 |
| 9 | Flocculation of Saccharomyces cerevisiae显示文摘 | Jin Y L Alex Speers R | 1998 | Food Research International1998，31，6： | 1 |
| 10 | 显示文摘 | ALEX K Y L CHAK K C | 2007 | J Phys Chem A2007，111，： | 1 |
| 11 | Fault current limiter applications in medium and high-voltage power distribution systems 显示文摘 | Alex Y Wu Yuexin Yin | 1998 | IEEE Transactions on Industrial Applications1998，34，1： | 1 |
| 12 | External network modeling for optimal power flow applications显示文摘 | Alex Papalexopoulos | 1995 | IEEE Transactions on Power System1995，10，2： | 1 |
| 13 | Stroke Cerebrovasc Dis显示文摘 | Michael Y Ronnie M Alex M | 2000 | J Stroke Cerebrovasc Dis2000，9，： | 1 |
| 14 | Electrolyte composition for Cu electrochemical mechanical planarization 显示文摘 | ABHINAV T CRAIG B IAN I S LI Y Z FRANCOIS D ALEX B JAMES M A | 2008 | Journal of The Electrochemical Society2008，155，7： | 1 |
| 15 | Effects of Bacillus coagulans ATCC 7050 on Growth Performance, Intestinal Morphology, and Microflora Composition in Broiler Chickens显示文摘 | ALEX T H SHU Y L TSUNG Y Y | 2012 | Animal Production Science2012，52，： | 1 |
| 16 | Cognitive function after anaesthesia in the elderly 显示文摘 | Alex Y Edwin J | 2003 | Best Pract Res Clin Anaesthesiol2003，17，2： | 1 |
| 17 | Abnormal white matter microstructure in schizophrenia: A voxelwise analysis of axial and radial diffusivity显示文摘 | Marc L. Seal Murat Yücel Alex Fornito Stephen J. Wood Ben J. Harrison Mark Walterfang Gaby S. Pell Christos Pantelis | 2008 | Schizophrenia Research2008，，1： | 1 |
| 18 | An efficient online path planner for outdoor mobile robots显示文摘 | Alex Y Sanjiv S Anthony S | 2000 | Robotics and Autonomous Systems2000，32，1： | 1 |
| 19 | Numerical Study on Effects of Coal Properties on Spontaneous Heating in Longwall Goaf Areas 显示文摘 | Li M Y Alex C S | 2008 | Fuel2008，87，15： | 1 |
| 20 | Transmission congestion management in competitive electricity markets显示文摘 | Harry S Hao S Y Alex P | 1998 | IEEE Trans on Power Systems1998，13，2： | 1 |
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