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| 1 | Giant hepatic extra-gastrointestinal stromal tumor treated with cytoreductive surgery and adjuvant systemic therapy:A case report and review of literature显示文摘BACKGROUND Primary extra-gastrointestinal stromal tumors(E-GIST)of the liver are rare.The clinical presentation may range from asymptomatic to bleeding or manifestations of mass effect.Oncologic surgery followed by adjuvant therapy with imatinib is the standard of care.However,under specific circumstances,a cytoreductive approach may represent a therapeutic option.We describe herein the case of an 84-year-old woman who presented with a tender,protruding epigastric mass.Abdominal computed tomography scan revealed a large,heterogeneous mass located across segments III,IV,V,and VIII of the liver.The initial approach was transarterial embolization of the tumor,which elicited no appreciable response.Considering the large size and central location of the tumor and the advanced age of the patient,non-anatomic complete resection was indicated.Due to substantial intraoperative bleeding and hemodynamic instability,only a near-complete resection could be achieved.Histopathology and immunohistochemical staining confirmed the diagnosis of primary E-GIST of the liver.Considering the risk/benefit ratio for therapeutic options,debulking surgery may represent a strategy to control pain and prolong survival.CASE SUMMARY Here,we present a case report of a patient diagnosed with E-GIST primary of the liver,which was indicated a cytoreductive surgery and adjuvant therapy with imatinib.CONCLUSION E-GIST primary of the liver is a rare conditional,the treatment is with systemic therapy and total resection surgery.However,a cytoreductive surgery will be necessary when a complete resection is no possible. | Michel Ribeiro Fernandes Caroline Lorenzoni Almeida Ghezzi Tomaz J M Grezzana-Filho Flávia Heinz Feier Ian Leipnitz Aljamir Duarte Chedid Carlos Thadeu Schmidt Cerski Marcio Fernandes Chedid Cléber RositoPinto Kruel | 2021 | World Journal of Gastrointestinal Surgery2021，13，3： | 3 |
| 2 | Energetic-protein supplementation in the last 60 days of gestation improves performance of beef cows grazing tropical pastures显示文摘Background: Nutrition is one of the most important factors that affect animal performance, and it therefore also impacts on financial results in beef systems. In this way, finding the best strategy for feeding supplements is of paramount importance. Aiming to evaluate the effect of supplement feeding strategies for beef cows in the last third of gestation, two experiments were conducted. In Experiment 1, 35 pregnant Nellore cows were assigned to a completely randomized design with four treatments: control, which received no supplement; supplementation for the last 30 d of gestation(30-d; 3.0 kg/d); supplementation for the last 60 d of gestation(60-d; 1.5 kg/d); or supplementation for the last 90 d of gestation(90-d; 1.0 kg/d). All supplemented treatments received the same total amount of supplement throughout the experiment: 90 kg(20% of crude protein). A second experiment(Experiment 2) was delineated to evaluate the effects of the amounts offered in Experiment 1 on intake and metabolism. Four multiparous pregnant Nellore cows were assigned to a 4 × 4 Latin square design, with periods of15 d each.Results: There was a linear effect of the number of days of supplementation on calving body weight(BW; P < 0.05)and a quadratic effect on BW change from parturition to d 31 post-calving(P < 0.05), with cows on the 60-d strategy losing less BW post-calving. No difference was found in offspring birth BW(P > 0.10). A significant linear effect on interval from parturition to conception(P < 0.05) was observed, with the highest calving to conception interval being observed in the 90-d strategy. The level of supplementation did not affect forage intake or neutral detergent fiber digestibility(P > 0.10). Nitrogen excreted through urine tended to increase linearly with the level of supplementation(P < 0.10).Conclusion: Providing 1.5 kg of supplement during the last 60 d of gestation improves cow performance after calving, reducing the magnitude of BW lost, and reduces the number of days from calving to re-conception in the following breeding season compared to the usually recommended period of supplementation of 90 d pre-partum. | Aline Gomes da Silva Mário Fonseca Paulino Edenio Detmann Henrique Jorge Fernandes Lincoln da Silva Amorim Román Enrique Maza Ortega Victor Valério de Carvalho Josilaine Aparecida da Costa Lima Felipe Henrique de Moura Mariana Benevides Monteiro Jéssika Almeida Bitencourt | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 2 |
| 3 | Comparative analysis of different flow eytometry based immune phenotypie methods for the analysis of CD59 and CD55 expression on major peripheral blood cell subsets显示文摘 | Martin-Ayuso M Almeida J | 2002 | Cytometry2002，50，3： | 1 |
| 4 | Metabolic effects of furaldehydes and impacts on biotechnological processes 显示文摘 | ALMEIDA J R M BERTILSSON M GORWA-GRAUSLUND M F | 2009 | Appl Microbiol Biotechnol2009，82，4： | 1 |
| 5 | Purification of metallurgical grade silicon by acid leaching显示文摘 | SANTOS I C GONCALVES A P SANTOS C S ALMEIDA M AFONSO M H CRUZ M J | 1990 | Hydrometallurgy1990，23，： | 1 |
| 6 | Comparative analysis of different flow cytometry based immunophenotypic methods for the analysis of CD55 and CD59 expression on major peripheral blood cell subsets显示文摘 | Hernandez-Campo P M Martin-Ayaso M Almeida J | 2002 | Cytometry2002，50，3： | 1 |
| 7 | Improving hierarchical cluster analysis: a new method with outlier detection and automatic clustering显示文摘 | ALMEIDA J A S BARBOSA L M S PAIS A A C C | 2007 | Chemometrics and Intelligent Labora- tory Systems2007，87，2： | 1 |
| 8 | Sulfide glass optical waveguides prepared by sol - gel processing 显示文摘 | ALMEIDA R M XU J | 2000 | Proc SPIE2000，3943，： | 1 |
| 9 | Oc- currence of Cryptosporidium parvum and Giardia duodenalis in healthy adult domestic ruminants 显示文摘 | Castro-Hermida J A Almeida A Gonzlez-Warleta M | 2007 | earasitol Res2007，101，5： | 1 |
| 10 | Competition between nitrate and nitrite reduction in denitrification by Pseudomonas fluorescens显示文摘 | Almeida J S Reis M Carrondo M | 1995 | Biotech Bioeng1995，46，： | 1 |
| 11 | Linear alkybenzene显示文摘 | De Almeida J L G Dufaux M Taarit Y B | 1994 | JAOCS1994，71，7： | 1 |
| 12 | Bowel wall thickening in children:CT findings显示文摘 | Almeida M Jose J Oneto J | 2008 | Radiographics2008，28，3： | 1 |
| 13 | Receptor activator of nuclear factor kappaB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss显示文摘 | Onal M Xiong J Chen X Thostenson JD Almeida M Manolagas SC O'Brien CA | | 0，，： | 1 |
| 14 | CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients显示文摘 | Savoldo Barbara Ramos Carlos Almeida Liu Enli Mims Martha P Keating Michael J Carrum George Kamble Rammurti T Bollard Catherine M Gee Adrian P Mei Zhuyong Liu Hao Grilley Bambi Rooney Cliona M Heslop Helen E Brenner Malcolm K Dotti Gianpie | 2011 | Journal of Clinical Investigation2011，，5： | 1 |
| 15 | Accurate discrimination of Barrett's esophagus and esophageal adenocarcinoma using a quantitative three-tiered algorithm and multimarker real-time reverse transcription-PCR显示文摘 | MITAS M ALMEIDA J S MIKHITARIAN K | 2005 | Clin Cancer Res2005，11，6： | 1 |
| 16 | Identifying improvements in water management of bus-washing stations in Brazil显示文摘 | Almeida C M V B Borges J D Bonilla S H | 2010 | Resources Conservation and Recycling2010，54，11： | 1 |
| 17 | Mito-chondrial respiratory chain and free radical generationin stroke 显示文摘 | Moro M A Almeida A Bola os J P Lizasoain I | 2005 | Free Radic Biol Med2005，39，： | 1 |
| 18 | Integrationof electric vehicles in the electric power system显示文摘 | Lopes J A P Soares F J Almeida P M R | 2011 | Proceedings of the IEEE2011，99，1： | 1 |
| 19 | Endocrinological and catecholaminergic alterations during sleep deprivation and recovery in male rats显示文摘 | Andersen M L Martins P J D 'Almeida V | 2005 | J Sleep Res2005，14，1： | 1 |
| 20 | Utility of flow cy- tometry immunophenotyping in multiple myeloma and other clonal plasma cell - related disorders 显示文摘 | Paiva B Almeida J Perez - Andres M | 2010 | Clinical Cytometry2010，78，4： | 1 |
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