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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | NEW TOXOPLASMA GONDII GENOTYPES ISOLATED FROM FREE-RANGE CHICKENS FROM THE FERNANDO DE NORONHA, BRAZIL: UNEXPECTED FINDINGS显示文摘 | Dubey J P Rajendran C Costa D G C Ferreira L R Kwok O C H Qu D Su C Marvulo M F V Alves L C Mota R A Silva J C R | 2010 | The Journal of Parasitology2010，，4： | 2 |
| 4 | Microstructure and flowbehavior of liquid water- gelatine-locust bean gum systems 显示文摘 | M M Alves C Gamier J Lefebvre | 2001 | Food Hydrocolloids2001，15，： | 1 |
| 5 | Positive solu- tions for a quasilinear elliptic equations of Kirchhoff type显示文摘 | Alves C O Correa F J S A Ma T F | 2005 | Comput Math Appl2005，4，： | 1 |
| 6 | 'Effect of tillage on fractal indices describing soil surface microrelief of a Brazilian Alfisol显示文摘 | Vi~lal'V~izquez E /Vliranda J G V Alves M C | 2006 | Geoderma2006，134，3： | 1 |
| 7 | Biomaterial-induced sar-coma:a novel model to study preneoplastic change显示文摘 | Kirkpatrick C J Alves A Khler H | 2000 | Am JPathol2000，156，4： | 1 |
| 8 | RBS lattice site location and damage recovery studies in GaN 显示文摘 | Alves E DaSilva M F Soares J C | 1999 | MRS Internet J Nitride Semiconductor Res1999，4，1： | 1 |
| 9 | Adsorption of chromium (VI) ion from aqueous solution by succinylated mercerized cellulose functionalized with quaternary ammonium groups显示文摘 | Leandro Vinícius Alves Gurgel Júlio César Perin de Melo Jorge Carvalho de Lena Laurent Frédéric Gil | 2009 | Bioresource Technology2009，，13： | 1 |
| 10 | Formation of complemen-t activating particles in aqueous solutions of Taxol:poss-ible role in hypersensitivity reactions显示文摘 | SZEBENI J ALVING C R SAVAV S | 2001 | Int Immunopharmacol2001，1，4： | 1 |
| 11 | Quantitative analyses of kidney injury molecule -1messenger RNA in kidney transplant recipients with graft dysfunc-tion显示文摘 | Nogare A L Joelsons G Pedroso J A Veronese F J Gonalves L F Manfro R C | 2010 | Transplant Proc2010，42，： | 1 |
| 12 | Quantitative study of caspase-3 activity in semen and after swim-up preparation in relation to sperm quality显示文摘 | Almeida C Cardoso MF Sousa M Viana P Gon(c)alves A Silva J | 2005 | Hum Reprod2005，20，5： | 1 |
| 13 | Theoretical optical parameters for Ⅲ-nitride semiconductors显示文摘 | Silva Pinto E de Paiva R de Carvalho L C Alves H W L Alves J L A | 2003 | Microelectronics Journal2003，34，： | 1 |
| 14 | Lean production as promoter of thinkers to achieve companies' agility 显示文摘 | Alves A C Dinis-Carvalho J Sousa R M | 2012 | The Learning Organiza- tion2012，19，3： | 1 |
| 15 | Changes in volatile com- position of Madeira wines during their oxidative ageing显示文摘 | Ci MARA J S ALVES M A MARQUES J C | 2006 | Anal Chim Acta2006，563，1： | 1 |
| 16 | Positive Solutions for a Quasilinear Elliptic Equation of Kirchhoff Type 显示文摘 | ALVES C O CORREA F J S A MAT F | 2005 | Comput Math Appl2005，49，： | 1 |
| 17 | Experimental and modeling study of gas dispersion in a double turbine stirred tank显示文摘 | Alves S S Maia C I Vasconcelos J M T | 2002 | Chemical Engineering Science2002，57，： | 1 |
| 18 | Infections in patients with diabetes mellitus : A review of pathogenesis 显示文摘 | Casqueiro J Casqueiro J Alves C | 2012 | Indian J En- docrinol Metab2012，，： | 1 |
| 19 | Analytical so- lution of single screw extrusion applicable to intermediate values of screw channel aspect ratio显示文摘 | Alves M V C Barbosa Jr J R Prata A T | 2009 | Journal of Food Engineering2009，92，2： | 1 |
| 20 | Optimization of vehicle suspension systems for improved comfort of road vehicles using flexible multibody dynamics显示文摘 | Gon?alves J C Ambrósio J C | | 0，，1： | 1 |
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