|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Plasma betatrophin levels in patients with liver cirrhosis显示文摘AIM: To investigate the plasma levels of betatrophin in patients with cirrhosis.METHODS: Forty patients diagnosed at the clinic with liver cirrhosis according to biological, ultrasonographic,or histological criteria were included.The severity of cirrhosis was classified according to Pugh's modification of Child's classification and MELD score. Insulin resistance(IR) was assessed by the Homeostasis Model Assessment. A total of 20 patients showed a MELD score higher than 14. The control group consisted in 15 sex-and aged-matched subjects.Fasting blood samples were obtained for subsequent analysis. Serum insulin was determined by Liaison automated immune chemiluminiscence assay(DiaSorin S.p.A.) using a sandwich assay. The sensitivity of the assay was 0.2 μU/mL. The intra and interassay variation coefficients were < 4% and < 10%,respectively. The normal values were between 2 and17 μU/mL. Human active betatrophin was analyzed by specific quantitative sandwich ELISA(Aviscera Bioscience). The sensitivity of the assay was 0.4 ng/mL, and the intra and interassay reproducibility were< 6% and < 10%, respectively.RESULTS: Plasma betatrophin levels were significantly increased in patients with cirrhosis compared with those in healthy subjects(P = 0.0001). Betatrophin levels were also associated with disease severity, being higher in Child-Pugh C patients compared to Child-Pugh B(P< 0.0005) and in patients who displayed a MELD score higher than 14 points compared to patients with lower punctuation(P = 0.01). In addition, we found a positive correlation between plasma betatrophin levels and the severity of cirrhosis according to Child-Pugh classification(r = 0.53; P < 0.01) or MELD score(r = 0.45; P <0.01). In the overall cohort, a moderate correlation between serum betatrophin and plasmatic bilirrubin(r= 0.39; P < 0.01) has been observed, as well as an inverse correlation between betatrophin and albumin(r =-0.41; P < 0.01) or prothrombin time(r =-0.44;P <0.01). Moreover, insulin resistance was observed in82.5% of the cirrhotic patients. In this group of patients,betatrophin levels were significantly higher than those in the group of patients without IR(P < 0.05).CONCLUSION: Plasma betatrophin is increased in patients with cirrhosis. This increase is related to the severity of cirrhosis, as well as with the emergence of insulin resistance. | Maria Teresa Arias-Loste Maria Teresa García-Unzueta Susana Llerena Paula Iruzubieta Angela Puente Joaquín Cabezas Carmen Alonso Antonio Cuadrado José Antonio Amado Javier Crespo Emilio Fábrega | 2015 | World Journal of Gastroenterology2015，21，37： | 9 |
| 2 | One decade of salivary proteomics: Currentapproaches and outstanding challenges显示文摘 | AMADO F M L FERREIRA R P VITORINAR | 2013 | ClinicalBiochemistry2013，46，6： | 1 |
| 3 | Inhibitory action of aqueous coffee ground extracts on the corrosion of carbon steel in HC1 solution 显示文摘 | TORRESS V V AMADO R S de sAC F FERNANDEZ T L da SILVA RIEHI C A TORRES A G D'ELIA E | 2011 | Corrosion Science2011，53，： | 1 |
| 4 | DCTdomain Watermarking Techniques for Still Images:Detector Performance Analysis and a New Structure显示文摘 | Hernández J R Amado M Pérez-González F | 2000 | IEEE Trans on Image Processing2000，9，1： | 1 |
| 5 | A family of human β3-galactosyltransferases显示文摘 | Amado K Almeida R Carneiro F | | 0，，21： | 1 |
| 6 | DCT-domain watermarking techniques for still images?detector performance analysis and a new structure显示文摘 | AMADO M PEREZGONZNALEZ F | 2000 | IEEE Transctions on Image Processing2000，9，1： | 1 |
| 7 | DCT-domain watermarking technique for still images:dector performance analysis and a new structure 显示文摘 | AMADO M GONZALEZ F P | 2000 | IEE Transactions on Image Procession2000，9，1： | 1 |
| 8 | DCT-Domain Watermarking Techniques for Still Images: Detector Performance Analysis and a New Structure 显示文摘 | Hermands J R Amado M Perezgonzales F | 2000 | IEEE Transaction on Image Processing2000，9，1： | 1 |
| 9 | DCT-domain watermarking techniques for still images: Detector performance analysis and a new structure 显示文摘 | Hernandez J R Amado M Perez-Gonzalez F | 2000 | IEEE Trans Image Process2000，9，： | 1 |
| 10 | Integrating the data envelopment analysis and the balanced scorecard approaches for enhanced performance assessment显示文摘 | AMADO A F SANTOS S P MARQUES P M | 2012 | Omega2012，，40： | 1 |
| 11 | DCT-domain watermarking techniques for still images: Detector performance analysis and a new structure 显示文摘 | J Hernandez M Amado F Perez-Gonzalez | 2000 | IEEE Trans on Image Processing2000，9，1： | 1 |
| 12 | Toward the definition ofa peptidome signature and protease profile in chronic periodontitis 显示文摘 | Trindade F Amado F Oliveira-Silva RP | 2015 | Proteomics Clin Appl2015，9，910： | 1 |
| 13 | Brown algae species as biomonitors of Zn and Cd at Sepetiba Bay, Rio de Janeiro,Brazil显示文摘 | Amado F Andrade L R Karez C S | 1999 | Marine Environmental Research1999，，38： | 1 |
| 14 | Blood levels of cytokines in brain-dead patients:relationship with circulating hormones and acute-phase reactants显示文摘 | Amado JA Lopez-Espadas F Vazquez-Barquero A | 1995 | Metabolism1995，44，6： | 1 |
| 15 | Gastrointestinal complications in renal transplant recipients : MITOS Study显示文摘 | Gil-Vemet S Amado A Ortega F | 2007 | Transplant Proc2007，39，7： | 1 |
| 16 | DCT-domain watermarking techniques for still image:detector performance analysis and a new structure显示文摘 | Hernandez J R Amado M Genzalez F P | 2000 | IEEE Trans on Image Processing2000，9，1： | 1 |
| 17 | Gastrointestinal complications in renal transplant recipients: MITOS study显示文摘 | Gil Vernet S Amado A Ortega F Alarcon A Bernal G Capdevila L | 2007 | Transplant Proc2007，39，： | 1 |
| 18 | Blood levels of cytokines in brain dead patients:relationship with circulating hormone and acute-phase reactants显示文摘 | Amado JA Lopez-Espadas F Vazquez-Barquero A | 1995 | Metabolism1995，44，6： | 1 |
| 19 | DCT-domain watermarking techniques for still images: Detector per-formance analysis and a new structure显示文摘 | Herna' ndez J R Amado M Pe'rez-Gonze'lez F | 2000 | JEEE Trans ImageProcessing2000，9，1： | 1 |
| 20 | DCT-dnmain watermarking techniques for still images:detector performance analysis and a new structure显示文摘 | Hernandez J R Amado M Perez-Gonzalez F | 2000 | IEEE Transaction on Image Processing2000，9，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员