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| 1 | Cardiac toxicity of trastuzumab in elderly patients with breast cancer显示文摘乳癌(BC ) 在 ≥ 被诊断;65 个岁女人在关于盒子的一半。专家们当前建议,那全身的治疗基于他们的全面条件和预期寿命与 BC 被提供给老病人,好处将超过治疗的风险,这能相当被期望。为年轻题目,相似对人的表皮的生长因素 receptor-2 (HER-2 ) 的 monoclonal 抗体, trastuzumab,代表一种有效治疗学的选择什么时候 BC 在表示上这受体。不幸地, trastuzumab 的管理与左室的机能障碍和长期的心失败(CHF ) 的出现被联系,因为有 homeostatic 的干扰,可能在心 HER-2 工作。基于登记的、回顾的分析在在没为 BC 给任何治疗的那些与 10%-15% 相比收到 trastuzumab 的老女人在 25% 附近报导了 CHF 的发生,并且 CHF 的风险被估计了在 > 更高双重;60-65 岁 trastuzumab 用户对非用户。极其先进的年龄和先存在的心脏病被显示了预先安排到 trastuzumab cardiotoxicity。因此,为有 trastuzumab 的治疗的更老的病人的选择应该主要基于他们的一般地位和 comorbidities 的存在;特别与 anthracyclines,以前的化疗应该也被考虑。一旦治疗开始了,努力应该被作保证常规心脏的监视。选择 biomarkers 的角色,例如心脏的 troponin,或新成像技术(三尺寸,织物 Doppler echocardiography,磁性的回声成像) 是有希望的,但是必须进一步在特别被调查老。而且,另外的研究被需要以便更好理解 trastuzumab 由影响旧心的机制。 | Andrea Denegri Tiziano Moccetti Marco Moccetti Paolo Spallarossa Claudio Brunelli Pietro Ameri | 2016 | Journal of Geriatric Cardiology2016，13，4： | 10 |
| 2 | Low-cost,μm-thick,tape-free electronic tattoo sensors with minimized motion and sweat artifacts显示文摘Electronic tattoos(e-tattoos),also known as epidermal electronics,are ultra-thin and ultra-soft noninvasive but skin-conformable devices with capabilities including physiological sensing and transdermal stimulation and therapeutics.The fabrication of e-tattoos out of conventional inorganic electronic materials used to be tedious and expensive.Recently developed cut-and-paste method has significantly simplified the process and lowered the cost.However,existing cut-and-paste method entails a medical tape on which the electronic tattoo sensors should be pasted,which increases tattoo thickness and degrades its breathability.To address this problem,here we report a slightly modified cut-and-paste method to fabricate low-cost,open-mesh e-tattoos with a total thickness of just 1.5μm.E-tattoos of such thinness can be directly pasted on human skin and conforms to natural skin texture.We demonstrate that this ultra-thin,tape-free e-tattoo can confidently measure electrocardiogram(ECG),skin temperature,and skin hydration.Heart rate and even respiratory rate can be extracted from the ECG signals.A special advantage of such ultra-thin e-tattoo is that it is capable of high-fidelity sensing with minimized motion artifacts under various body movements.Effects of perspiration are found to be insignificant due to the breathability of such e-tattoos. | Youhua Wang Yitao Qiu Shideh Kabiri Ameri Hongwoo Jang Zhaohe Dai YongAn Huang Nanshu Lu | 2018 | npj Flexible Electronics2018，2，1： | 9 |
| 3 | 先天性上睑下垂患者100例弱视致病原因的探讨(英文)显示文摘目的:评估先天性上睑下垂患者的弱视发病情况。方法:在本横断面研究中,包括1岁以上的先天性上睑下垂患者100例(114眼)。最佳矫正视力小于10/10或两眼之间至少相差2/10者定义为弱视。年幼患者不能进行斯内伦视力表检测者,观察其注视情况。不同弱视患者的类型:1)屈光参差性弱视:散光性屈光参差≥1.00D;远视性球镜屈光参差≥1.00D,近视性球镜屈光参差≥-3.00D(睫状肌麻痹);2)斜视性弱视,3)形觉剥夺性弱视(SDA)。观察弱视的总发病率及类型,并对单侧和双侧上睑下垂患者进行比较。结果:弱视的发生率在上睑下垂患者为39/114(34.2%),其具体原因:屈光参差性弱视占29.8%,SDA占10.5%,斜视性弱视4.3%,严重的上睑下垂患者弱视发病率更高,视轴遮盖者(OA)占76%,而视轴未遮盖者只占22%。在视轴遮盖的单侧眼睑下垂患者,散光屈光参差性弱视发生率更高,在双侧眼睑下垂至少1眼视轴遮盖者,球镜屈光参差性弱视发生率更高。无论单侧和双侧上睑下垂,如果有视轴遮盖,则SDA比较多见。结论:由于屈光参差性弱视比SDA发生率更高,关注导致的弱视所有原因对于预防儿童上睑下垂所致的弱视极其重要。 | Abolfazl Kasaee Alireza Yazdani-Abyaneh Syed Ziaeddin Tabatabaie Alireza K.Jafari Ahmad Ameri Bahram Eshraghi Vafa Samarai Meysam Mireshghi Mohammad Taher Rajabi | 2011 | 国际眼科杂志2011，11，3： | 4 |
| 4 | Clinical characteristics and prognostic impact of atrial fibrillation in patients with chronic heart failure显示文摘AIM To assess the prevalence, clinical characteristics and independent prognostic impact of atrial fibrillation(AF) in chronic heart failure(CHF) patients, and the potential protective effect of disease-modifying medications, particularly beta-blockers(BB). METHODS We retrospectively reviewed the charts of patients referred to our center since January 2004, and collected all clinical information available at their first visit. We assessed mortality to the end of June 2015. We compared patients with and without AF, and assessed the association between AF and all-cause mortality by multivariate Cox regression and Kaplan-Meyer analysis, particularly accounting for ongoing treatment with BB.RESULTS A total of 903 patients were evaluated(mean age 68 ± 12 years, 73% male). Prevalence of AF was 19%, ranging from 10% to 28% in patients ≤ 60 and ≥ 77 years, respectively. Besides the older age, patients with AF had more symptoms(New York Heart Association II-III 60% vs 44%), lower prevalence of dyslipidemia(23% vs 37%), coronary artery disease(28% vs 52%) and left bundle branch block(9% vs 16%). On the contrary, they more frequently presented with an idiopathic etiology(50% vs 24%), a history of valve surgery(13% vs 4%) and received overall more devices implantation(31% vs 21%). The use of disease-modifying medications(i.e., BB and ACE inhibitors/angiotensin receptor blockers) was lower in patients with AF(72% vs 80% and 71% vs 79%, respectively), who on the contrary were more frequently treated with symptomatic and antiarrhythmic drugs including diuretics(87% vs 69%) and digoxin(51% vs 11%). At a mean follow-up of about 5 years, all-cause mortality was significantly higher in patients with AF as compared to those in sinus rhythm(SR)(45% vs 34%, P value < 0.05 for all previous comparisons). However, in a multivariate analysis including the main significant predictors of allcause mortality, the univariate relationship between AF and death(HR = 1.49, 95%CI: 1.15-1.92) became not statistically significant(HR = 0.98, 95%CI: 0.73-1.32). Nonetheless, patients with AF not receiving BB treatment were found to have the worst prognosis, followed by patients with SR not receiving BB therapy and patients with AF receiving BB therapy, who both had similarly worse survival when compared to patients with SR receiving BB therapy.CONCLUSION AF was highly prevalent and associated with older age, worse clinical presentation and underutilization of disease-modifying medications such as BB in a population of elderly patients with CHF. AF had no independent impact on mortality, but the underutilization of BB in this group of patients was associated to a worse long-term prognosis. | Lorenzo Gigli Pietro Ameri Gianmarco Secco Gabriele De Blasi Roberta Miceli Alessandra Lorenzoni Francesco Torre Francesco Chiarella Claudio Brunelli Marco Canepa | 2016 | World Journal of Cardiology2016，8，11： | 4 |
| 5 | Genetic mapping of QTL for agronomic traits and grain mineral elements in rice显示文摘Malnutrition is one of the prevailing health problems worldwide, affecting a large proportion of the populations in rice-consuming countries. Breeding rice varieties with increased concentrations of elements in the grain is considered the most cost-effective approach to alleviate malnutrition. Development of molecular markers for high grain concentrations of essential elements, particularly Zn, for use in marker-assisted selection (MAS) can hasten breeding efforts to develop rice varieties with nutrient-dense grain. We performed QTL mapping for four agronomic traits: days to 50% flowering, plant height, number of tillers, grain yield, and 13 grain elements: As, B, Ca, Co, Cu, Fe, K, Mg, Mn, Mo, Na, P, and Zn, in two doubled-haploid populations derived from the crosses IR64 × IR69428 and BR29 × IR75862. These populations were phenotyped during 2015DS and 2015WS at IRRI, Los Ba os, The Philippines, and genotyped them with a 6 K SNP chip. Inclusive composite interval mapping revealed 15 QTL for agronomic traits and 50 QTL for grain element concentration. Of these, eight QTL showed phenotypic variance of >25% and 11 QTL were consistent across seasons. There were seven QTL co-localization regions containing QTL for more than two traits. Twenty five epistatic interactions were detected for two agronomic traits and seven mineral elements. Several DH lines with high Fe and Zn in polished rice were identified. These lines can be used as donors for breeding high-Zn rice varieties. Some of the major QTL can be further validated and used in MAS to improve the concentrations of nutritive elements in rice grain. | Gwen Iris Descalsota-Empleo Amery Amparado Mary Ann Inabangan-Asilo Frances Tesoro James Stangoulis Russell Reinke B.P.Mallikarjuna Swamy | 2019 | The Crop Journal2019，7，4： | 4 |
| 6 | The study of key design parameters effects on the vortex tube performance显示文摘In this paper, energy separation effect in a vortex tube has been investigated using a CFD model. Thenumerical simulation has been done due to the complex structure of flow. The governing equationshave been solved by FLUENT code in 2D and 3D compressible and turbulent model. The effects ofgeometrical and thermo-physical parameters have been investigated. The results have shown that theoptimum length to diameter ratio is from 25 to 35. Increasing the number of nozzles from 2 to 4 withconvergent shape is found to be an efficient configuration for the swirl generator. The optimum valueof orifice diameter to tube diameter ratio, for the maximum cold air temperature difference and efficiency,has been determined to be around 0.58. The results show that if the inlet pressure increases upto a critical value, the efficiency will increase. Nevertheless, if it increases to higher values, the efficiencywill decrease. Moreover, it is found out that increasing the cold fraction decreases the coldtemperature difference and efficiency. | Mohammad Ameri Behrooz Behnia | 2009 | Journal of Thermal Science2009，18，4： | 2 |
| 7 | Facile and one-pot,electro-organic synthesis of a new bis-quinone by the ECCE mechanism in green media显示文摘Electrochemical oxidation of 4-methyl catechol(1a) is investigated in the presence of 1,3-indandione(3)as nucleophile in phosphate buffer solution(0.2 mol/L,pH 6) mixed with ethanol as organic green solvent(50/50) using cyclic voltammetry and controlled-potential coulometry.The results indicated thatquinones derived from electro-oxidation of 1a,participated in a 1,4-Michael addition reaction with1,3-indandione(3) under ECCE mechanism.In this direction,a new bis-quinone was synthesized in high yield and good purity using a facile and convenient electrochemical pathway by carbon anode electrodes in an undivided cell. | Mohsen Ameri Alireza Asghari Ali Amoozadeh Mohammad Bakherad Davood Nematollahi | 2014 | Chinese Chemical Letters2014，25，12： | 2 |
| 8 | 基于计算流体力学和人工神经网络对断阶式滑行艇的水动力性能预测显示文摘In the present paper,the hydrodynamic performance of stepped planing craft is investigated by computational fluid dynamics(CFD)analysis.For this purpose,the hydrodynamic resistances of without step,one-step,and two-step hulls of Cougar planing craft are evaluated under different distances of the second step and LCG from aft,weight loadings,and Froude numbers(Fr).Our CFD results are appropriately validated against our conducted experimental test in National Iranians Marine Laboratory(NIMALA),Tehran,Iran.Then,the hydrodynamic resistance of intended planing crafts under various geometrical and physical conditions is predicted using artificial neural networks(ANNs).CFD analysis shows two different trends in the growth rate of resistance to weight ratio.So that,using steps for planing craft increases the resistance to weight ratio at lower Fr and decreases it at higher Fr.Additionally,by the increase of the distance between two steps,the resistance to weight ratio is decreased and the porpoising phenomenon is delayed.Furthermore,we obtained the maximum mean square error of ANNs output in the prediction of resistance to weight ratio equal to 0.0027.Finally,the predictive equation is suggested for the resistance to weight ratio of stepped planing craft according to weights and bias of designed ANNs. | Hamid Kazemi M.Mehdi Doustdar Amin Najafi Hashem Nowruzi M.Javad Ameri | 2021 | Journal of Marine Science and Application2021，20，1： | 2 |
| 9 | Efficacy of a traditional Persian medicine preparation for radiation-induced xerostomia:a randomized,open-label,active-controlled trial显示文摘BACKGROUND: Xerostomia is one of the most common side effects of radiation therapy among patients with head and neck cancers(HNC). However, conventional medicine lacks an effective treatment for radiation-induced xerostomia.OBJECTIVE: Synthesizing the traditional use of Alcea digitata and Malva sylvestris with their known beneficial effects from recent studies, we evaluated the efficacy of the herbs in the quality of life(QOL) of HNC patients with radiation-induced xerostomia.DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: This study is a randomized, double-arm, open-label active-controlled clinical trial. We evaluated the effect of A. digitata and M. sylvestris on QOL of HNC patients with radiation-induced xerostomia compared with Hypozalix(artificial saliva). Patients were enrolled from the Imam Hossein Hospital's oncology clinic in Shahid Beheshti University of Medical Sciences, Tehran, Iran.MAIN OUTCOME MEASURES: Primary outcome measures in this trial were changes in patients' QOL assessed by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Head and Neck Module(EORTC QLQ-H&N 35).RESULTS: Between-group analysis showed that the intervention group patients obtained significantly lower(better) total EORTC QLQ-H&N 35 scores as compared to the control group at the end of the intervention period(P = 0.007). Mean scores of dry mouth of EORTC QLQ-H&N 35 was also significantly lower(better) in the intervention group as compared to the control group(P = 0.017).CONCLUSION: Traditional Persian medicine preparation of hollyhocks and common mallow should be considered as a suitable treatment for xerostomia and improving QOL in HNC patients with radiation-induced xerostomia.TRIAL REGISTRATION: The trial was registered in Clinical Trials.gov with Identifier: NCT02854358. | Ghazaleh Heydarirad Hossein Rezaeizadeh Rasool Choopani Seyed Hamdollah Mosavat Ahmad Ameri | 2017 | Journal of Integrative Medicine2017，15，3： | 2 |
| 10 | Prognostic Value of Promoter Hypermethylation of Retinoic Acid Receptor Beta (RARB) and CDKN2 (p16/MTS1) in Prostate Cancer显示文摘Objective: The molecular mechanism of prostate cancer is poorly understood. The aim of the study was to investigate the prevalence and prognostic value of promoter hypermethylation of retinoic acid receptor beta (RARB) and p16 among benign prostatic hyperplasia (BPH) and prostate cancer patients. Methods: In this case-control study, 63 patients were included in three groups; 21 with BPH as the control group, 21 with prostate cancer and good prognostic factors (based on prostate-specific antigen, Gleason score and stage) as good prognosis group, and 21 with prostate cancer and poor prognostic features as poor prognosis group. The prostate biopsy specimen of each individual was examined for hypermethylation of RARB and p16 promoters by methylation specific PCR (MSPCR). Results: Seven (33.3%) patients with good prognosis and 15 (71.4%) patients with poor prognosis were positive for RARB methylation, which were significantly higher than controls (P <0.0001). p16 promoter methylation was shown in 19.0% and 47.6% patients with good and poor prognosis, respectively. The RARB and p16 promoter methylation in the poor prognosis group was significantly higher than that in the good prognosis group (P =0.02 for RARB and P<0.0001 for p16). Conclusion: Hypermethylation of RARB and p16 promoters may predict prognosis in prostate cancer. | Ameri A Alidoosti A Hosseini Y Parvin M Emranpour MH Taslimi F Salehi E Fadavi P | 2011 | Chinese Journal of Cancer Research2011，23，4： | 2 |
| 11 | The study of capacity enhancement of the Chabahar gas turbine installation using an absorption chiller显示文摘 | M Ameri S H Hejazi | 2004 | Applied Thermal Engineering2004，，24： | 1 |
| 12 | Postmarketing study of the use of flunarizine in vestibular vertigo and in migraine显示文摘 | Verspeelt J De Locht P Amery WK | 1996 | Eur J Clin pharma- col1996，51，1： | 1 |
| 13 | Postmarketing study of the use of flunarizine in vestibular vertigo and in migraine显示文摘 | Verspbeh J De Lacht P Amery WK | 1996 | Eur J Clin Pharma- cd1996，51，1： | 1 |
| 14 | Pasireotide,an IGF-I action inhibitor,prevents growth hormone and estradiol-induced mammary hyperplasia显示文摘 | Kleinberg DL Ameri P Singh B | 2011 | Pituitary2011，14，1： | 1 |
| 15 | An immunoglobulin binding protein(Antigen 5)of the stable fly(Diptera:Muscidae)salivary gland stimulates bovine immune responses显示文摘 | Ameri M X.Wang M.J.Wilkerson | | 0，，01： | 1 |
| 16 | Some types of filters in MTL-algebras显示文摘 | BORZOOEI R A SHOAR S K AMERI R | 2012 | Fuzzy Sets and Systems2012，187，： | 1 |
| 17 | Electrosynthesis of hydroquinonethioethers using electrochemical oxidation of hydroquinone in the presence of thiouracil derivatives显示文摘Electrochemical oxidation of hydroquinone(1a) has been studied in the presence of 6-methyl-2-thiouracil(3a) and 6-propyl-2-thiouracil(3b) as nucleophiles in a DMF/buffer mixture,using cyclic voltammetry and controlled-potential coulometry.The results indicated that the p-quinone(2a) derived from 1a participates in a 1 4-Michael addition reaction with the thiouracil derivatives(3a–b) to form the corresponding hydroquinonethioether derivatives(6a–6b).The electrosynthesis of these compounds(6a–b) has been successfully performed on carbon rod electrodes in an undivided cell in good yield and purity. | Mohsen Ameri Alireza Asghari Ali Amoozadeh Hassan Daneshinejad Davood Nematollahi | 2014 | Chinese Chemical Letters2014，25，5： | 1 |
| 18 | Postmarketing study of the use of flunarizine in vestibular vertigo and in migraine显示文摘 | Verspeelt J De Locht P Amery WK | 1996 | Eur J Clin pharmacol1996，51，1： | 1 |
| 19 | The effects of Aconitum alkaloids on the central nervous system显示文摘 | Ameri A | 1998 | Prog Neurobiol1998，56，2： | 1 |
| 20 | Bovine subclinical ketosis in dairy herds in Iran显示文摘 | Sakha M Ameri M Shrifi H | 2007 | Veterinary Research Communication2007，31，： | 1 |
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