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| 1 | Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs) are chronic disorders of modern society, requiring management strategies aimed at prolonging an active life and establishing the exact etiology and pathogenesis.These idiopathic diseases have environmental, genetic,immunologic, inflammatory, and oxidative stress components. On the one hand, recent advances have shown that abnormal immune reactions against the microorganisms of the intestinal flora are responsible for the inflammation in genetically susceptible individuals. On the other hand, in addition to T helper cell-type(Th) 1 and Th2 immune responses,other subsets of T cells, namely regulatory T cells and Th17 maintained by IL-23 are likely to develop IBD. IL-23 acts on innate immune system members and also facilitates the expansion and maintenance of Th17 cells. The IL-17/IL-23 axis is relevant in IBD pathogenesis both in human and experimental studies. Novel biomarkers of IBD could be calprotectin,microRNAs, and serum proinflammatory cytokines.An efficient strategy for IBD therapy is represented by the combination of IL-17 A and IL-17 F in acute IL-17 A knockout TNBS-induced colitis, and also definite decrease of the inflammatory process in IL-17 F knockout, DSS-induced colitis have been observed.Studying the correlation between innate and adaptive immune systems, we hope to obtain a focused reviewin order to facilitate future approaches aimed at elucidating the immunological mechanisms that control gut inflammation. | Cristina-Sorina Cǎanǎ Ioana Berindan Neagoe Vasile Cozma Cristian Magdas Flaviu Tǎbǎan Dan Lucian Dumitrasu | 2015 | World Journal of Gastroenterology2015，21，19： | 37 |
| 2 | 血根碱对肉鸡生长性能、相对器官重量、盲肠菌群、血清胆固醇水平以及肉品质的影响显示文摘研究旨在探索日粮添加血根碱(SGV)对肉鸡生长性能、相对器官重量、盲肠菌群、血清胆固醇水平和腿肌丙二醛含量的影响。选用840日龄雄性肉鸡(罗斯品种)饲养于28个稻草垫上,随机分为4个处理:玉米-豆粕型基础对照日粮、基础日粮中添加卑霉素10 ppm作为生长促进剂(AGP)、基础日粮中添加SGV 20 ppm(SGV20)和50 ppm(SGV50)。与饲喂基础日粮的肉鸡相比,基础日粮中添加AGP组、SGV20组和SGV50组的肉鸡最终体重(BW)、日增重、饲料转化率(FCR)显著改善(P<0.05)。与对照组相比,SGV20喂养组的肉鸡相对空肠重量显著降低(P<0.05),所有添加SGV组肉鸡相对空肠或回肠长度显著升高(P<0.05)。SGV20组较对照组肉鸡肠道菌群有所改变,尤其是盲肠乳酸菌数增加,但AGP组无改变。SGV20组或SGV50组肉鸡的总胆固醇水平较对照组显著降低(P<0.05),控制饮食物显著降低(P<0.05)。添加SGV后,作为脂质过氧化反应指示剂的腿肌丙二醛含量显著降低(P<0.05)。研究表明,在肉鸡日粮中补充SGV 20或50 ppm可以提高肉鸡生长性能,改变多种生物和生理参数,如相对器官重量、血清胆固醇水平、肠道菌群和肉品质。 | Lee K W Kim J S Oh S T Kang C W An B K | 2015 | 饲料博览2015，0，3： | 2 |
| 3 | A serum glycomics approach to breast cancer biomarkers显示文摘 | Kirmiz C Li B An HJ | 2007 | Mol Cell Proteomics2007，6，1： | 1 |
| 4 | Pliocene uplift of the northern Tibetan Plateau显示文摘 | Zheng H B Powell C McA An Z S | 2000 | Geology2000，28，： | 1 |
| 5 | A novel drought-inducible gene,A TAF1,encodes a NAC family protein that negatively regulates the expression of stress-responsive genes in Arabidopsis显示文摘 | LU P L CH EN N Z AN R SU Z QI B S REN F CHEN J WANG X C | 2007 | Plant Molecular Biology2007，63，2： | 1 |
| 6 | Structural and functional analysis of the globular head domain of p115 provides insight into membrane tethering显示文摘 | An Y Chen C Y Moyer B | 2009 | J Mol Biol2009，391，1： | 1 |
| 7 | Inhibition of human complemen t by B-glycyrrh et inicacid显示文摘 | K roes B H B eukelm an C J Vandenberg AJ | 1997 | Immunology1997，90，： | 1 |
| 8 | Simulation of soil be- havior under blast loading 显示文摘 | An J Tuan C Y Cheeseman B A | 2011 | international Journal of Geome- chanics2011，11，4： | 1 |
| 9 | Dry or humid? Mid-Holocene humidity changes in arid and semi-arid China 显示文摘 | An C B Feng Z D Barton L | 2006 | Quat Sci Rev2006，25，： | 1 |
| 10 | Decline in the AIDS and death rates in the EuroSIDA study: an observational study显示文摘 | A Mocroft B Ledergerber C Katlama O Kirk P Reiss A d’Arminio Monforte B Knysz M Dietrich AN Phillips JD Lundgren | 2003 | 2003 (9377)2003，，9377： | 1 |
| 11 | Positron eission tomo- aphy straining in the evaluation of ular careinmna显示文摘 | KH AN MA COM B S C S BRUNT EM | 2009 | Ann Nu- 1 Med2009，14，2： | 1 |
| 12 | Effect of Chromium Picolinate and Riboflavin Supplementation on the Performance and Body Composition of Broiler Under Heat Stress显示文摘 | Kwon S K AN B K Kang C W | 1999 | Korean J Anim Sci1999，41，3： | 1 |
| 13 | Funtional roles of therhohinase pathnay and pvotein kinase C in the regulation of cerebrovascular constriction mediated by hem oglobin:relearnto subarachnoid hemorrhage and rasospasm显示文摘 | W ickman G I an C Vollrath B | 2003 | Circ Kes2003，92，3： | 1 |
| 14 | Stratigraphic Evidence of Megahumid Mid-Holocene Climate in the Western Part of the Chinese Loess Plateau显示文摘 | Feng Z D An C B Tang L Y | 2004 | Glob Planet Change2004，43，： | 1 |
| 15 | Spartina invasion in China: im- plications for invasive species management and future research显示文摘 | AN S Q GU B H ZHOU C F WANG Z S DENG Z F ZHI Y B LI H L CHEN L YU D H LIU Y H | 2007 | Weed Research2007，47，： | 1 |
| 16 | Expression and transcriptional regulation of the GnRH receptor gene in human neuronal cells显示文摘 | YEUNG C M AN B S CHENG C K | 2005 | Mol Hum Reprod2005，11，83： | 1 |
| 17 | The effects of a lumbar support on repositioning error in subjects with low back pain显示文摘 | NEWCOMER K LASKOWSKI E R YU B JOHNSON J C AN K N | 2001 | Arch Phys Med Rehabil2001，2，： | 1 |
| 18 | Shaped-selected synthesis of nanocrystalline SnS in different alkaline media 显示文摘 | AN C H TANG K B JIN Y | 2003 | Journal of Crystal Growth2003，252，： | 1 |
| 19 | Toll-like receptors and macrophage activation in atherosclerosis显示文摘 | SENEVIRATNE AN SIVAGURUNATHAN B MONACO C | 2012 | Clin Chim Acta2012，413，12： | 1 |
| 20 | Laser ablation induced agglomeration of Cu nanopartic1es in sodium dodecyl sulfate aqueous solution显示文摘 | YAN R B Z DINU C Z HUANG Y CARUSO AN CHRlSEY D B | 2010 | Journal of Optoelectronics and Advanced Materials2010，12，： | 1 |
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