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| 1 | Prevalence of obesity and diabetes in patients with schizophrenia显示文摘AIM To compare the prevalence of diabetes in patients with schizophrenia treated at a community mental health center with controls in the same metropolitan area and to examine the effect of antipsychotic exposure on diabetes prevalence in schizophrenia patients. METHODS The study was a comprehensive chart review of psychiatric notes of patients with schizophrenia and schizoaffective disorder treated at a psychosis program in a community mental health center. Data collected included psychiatric diagnoses, diabetes mellitus diagnosis, medications, allergies, primary care status, height, weight, body mass index(BMI), substance use and mental status exam. Local population data was downloaded from the Centers for Disease Control Behavioral Risk Factor Surveillance System. Statistical methods used were χ~2 test, Student's t test, general linear model procedure and binary logistic regression analysis.RESULTS The study sample included 326 patients with schizophrenia and 1899 subjects in the population control group. Demographic data showed control group was on average 7.6 years older(P = 0.000), more Caucasians(78.7% vs 38.3%, P = 0.000), and lower percentage of males(40.7% vs 58.3%, P = 0.000). Patients with schizophrenia had a higher average BMI than the subjects in the population control(32.11, SD = 7.72 vs 27.62, SD = 5.93, P = 0.000).Patients with schizophrenia had a significantly higher percentage of obesity(58.5% vs 27%, P = 0.000) than the population group. The patients with schizophrenia also had a much higher rate of diabetes compared to population control(23.9% vs 12.2%, P = 0.000). After controlling for age sex, and race, having schizophrenia was still associated with increased risk for both obesity(OR = 3.25, P = 0.000) and diabetes(OR = 2.42, P = 0.000). The increased risk for diabetes remained even after controlling for obesity(OR = 1.82, P = 0.001). There was no difference in the distribution of antipsychotic dosage, second generation antipsychotic use or multiple antipsychotic use within different BMI categories or with diabetes status in the schizophrenia group. CONCLUSION This study demonstrates the high prevalence of obesity and diabetes in schizophrenia patients and indicates that antipsychotics may not be the only contributor to this risk. | Aniyizhai Annamalai Urska Kosir Cenk Tek | 2017 | World Journal of Diabetes2017，8，8： | 6 |
| 2 | Management of refractory ascites in cirrhosis:Are we out of date?显示文摘Cirrhosis is a major cause of morbidity and mortality worldwide with liver transplantations as it only possible cure.In the face of a significant organ shortage many patients die waiting.A major complication of cirrhosis is the development of portal hypertension and ascites.The management of ascites has barely evolved over the last hundred years and includes only a few milestones in our treatment approach,but has overall significantly improved patient morbidity and survival.Our mainstay to ascites management includes changes in diet,diuretics,shunt procedures,and large volume paracentesis.The understanding of the pathophysiology of cirrhosis and portal hypertension has significantly improved in the last couple of decades but the changes in ascites management have not seemed to mirror this newer knowledge.We herein review the history of ascites management and discuss some its current limitations. | Alagappan Annamalai Lauren Wisdom Megan Herada Mazen Nourredin Walid Ayoub Vinay Sundaram Andrew Klein Nicholas Nissen | 2016 | World Journal of Hepatology2016，8，28： | 4 |
| 3 | p-Coumaric acid ameliorates ethanol-induced kidney injury by inhibiting inflammatory cytokine production and NF-κB signaling in rats显示文摘Objective: To examine the effects of p-coumaric acid on ethanol-induced kidney injury in Swiss Wistar rats.Methods: Ethanol(25% v/v) was used to induce nephrotoxicity in rats. p-Coumaric acid was orally administered at 50, 100, or 200 mg/kg body weight. The levels of oxidative parameters were determined; pro-inflammatory biomarkers were analyzed by Western blotting and apoptotic protein was analyzed by immunohistochemistry. Results: Ethanol treated rats showed decreased levels of antioxidants and aberrant production of pro-inflammatory cytokines(IL-6, IL1β, TNF-α), NF-κB activation and imbalance of proand anti-apoptotic proteins(Bcl-2, Bax, caspase 3). Meanwhile, p-coumaric acid restored antioxidant levels and decreased the levels of inflammatory cytokines, NF-κB, and proapoptotic proteins and increased Bcl-2 expression. Conclusions: p-Coumaric acid ameliorates ethanol-induced kidney injury by restoring antioxidant production and suppressing cellular apoptosis and inhibiting NF-κB expression.p-Coumaric acid should be further investigated as a promising candidate for ethanol-induced kidney toxicity. | Ramakrishnan Sabitha Kumari Nishi Vinoth Prasanna Gunasekaran Govindhan Annamalai Balupillai Agilan Mathan Ganeshan | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，5： | 2 |
| 4 | Recovering device drivers显示文摘 | Michael M. Swift Muthukaruppan Annamalai Brian N. Bershad Henry M. Levy | 2006 | ACM Transactions on Computer Systems (TOCS)2006，，4： | 2 |
| 5 | Screening and antibacterial efficacy of selected Indian medicinal plants显示文摘Objective: To evaluate the antibacterial efficacy of five Indian medicinal plants such as Acalypha indica L.(A. indica), Aerva lanata(L.) Juss. ex Schult.(A. lanata), Clerodendrum inerme(L.) Gaertn., Pergularia daemia(Forsk.) Chiov. and Solanum surattense Burm. f. against opportunistic bacterial pathogens isolated from HIV infected patients for the potential phytoconstituents in plant extracts.Methods: The opportunistic bacterial pathogens such as Escherichia coli(E. coli),Pseudomonas aeruginosa, Salmonella typhi and Serratia marcescens from Gramnegative group and Staphylococcus aureus from Gram-positive group were isolated from HIV infected patients. The antibacterial efficacy of ethanolic extracts of selected medicinal plants was carried out by disc diffusion method. The potential phytoconstituents of medicinal plant extracts were identified by gas chromatography and mass spectrometry(GC–MS) analysis.Results: Among the five medicinal plants tested, A. indica and A. lanata showed the significant antibacterial activity. A. indica showed potential activity against Staphylococcus aureus and E. coli. A. lanata significantly exhibited antibacterial activity against E. coli, Salmonella typhi and Pseudomonas aeruginosa. A total of 19 phytoconstituents were identified in the ethanolic extract of A. indica and A. lanata by GC–MS analysis respectively.Conclusions: The results of the present investigation revealed that A. indica and A. lanata, possessed significant antibacterial activity when compared with the other plant extracts tested. The presence of 3-O-methyl-D-glucose by GC–MS analysis in both A. indica and A. lanata extracts has not been reported elsewhere in the literature and the findings in this study could be the first one to report. | Suresh Mickymaray Mohammad Saleh Al Aboody Pradipta Kumar Rath Panneerselvam Annamalai Thajuddin Nooruddin | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，3： | 2 |
| 6 | Optimization of air-cooled condensers显示文摘 | Lau S Annamalai K Shelton V | 1987 | ASME Journal of Energy Resources1987，109，2： | 1 |
| 7 | CFD Analysis for Simulated Altitude Testing of Rocket Motors 显示文摘 | Sankaran S Satyanarayana T N V Annamalai K | 2002 | Canadian Aeronautics & Space Journal2002，48，2： | 1 |
| 8 | Coupled dynamics over the Indian Ocean:Spring initiation of the zonal mode显示文摘 | ANNAMALAI H MURTUGUDDE R POTEMRA J | 2003 | Deep-Sea Res2003，50，12： | 1 |
| 9 | Co-firing of coal and biomass fuel blends显示文摘 | Sam M Annamalai K | 2001 | Progress in Energy and Combustion Science2001，27，： | 1 |
| 10 | emonstration of a 320×256 two-color focal plane array using InAs/InGaAs quantum dots in well detectors显示文摘 | Sanjay Krishna Darren Forman Senthil Annamalai | 2005 | Applied Physics Letters2005，86，19： | 1 |
| 11 | Role of cerebrospinalfluid shunting for human immunodeficiency virus-positive patientswith tuberculous meningitis and hydrocephalus显示文摘 | Nadvi SS Nathoo N Annamalai K | 2000 | Neurosurger-y2000，47，3： | 1 |
| 12 | Influences of re-entrant combustion chamber geometry on the performance of Pongamia biodiesel in a DI diesel engine显示文摘 | S. Jaichandar K. Annamalai | 2012 | Energy2012，，1： | 1 |
| 13 | Possible impact of theIndian Ocean SST on the Northern Hemisphere circulation duringEl Nino显示文摘 | Annamalai H Okajima H Watanabe M | 2007 | J Climate2007，20，： | 1 |
| 14 | Co-firing of coal and biomass fuel blends显示文摘 | SAMI M ANNAMALAI K WOOLDRIDGE M | 2001 | Prog Energy Combust Sci2001，27，2： | 1 |
| 15 | Character-ization of protease from Alcaliger faecali and its antibacterial activity on fish pathogens显示文摘 | Annamalai N Kumar A Saravanakumar A | 2011 | J Environ Biol2011，32，6： | 1 |
| 16 | Purification and characterization of chitinase from Alcallgenes faeealis AU02 by utilizing marine wastes and its antioxidant ac- tivit显示文摘 | Annamalai N Veeramuthu Rajeswari M Vijayalakshmi S | | Ann Microhiol0，61，4： | 1 |
| 17 | Evaluation of the performance of supersonic exhaust diffuser using scaled down models显示文摘 | ANNAMALAI K VISVANATHAN K SRIRAMULU V | 1998 | Experimental Thermal and Fluid Science1998，17，： | 1 |
| 18 | The mean evolution and variability of the Asian summer monsoon: Comparison of ECMWF and NCEP/NCAR reanalysis 显示文摘 | Annamalai H Slingo J M Sperbcr K R | 1999 | Monthly Weather Review1999，127，6： | 1 |
| 19 | Thermostable and alkaline tolerant xylanase production by Bacillus subtilis isolated from marine environment显示文摘 | Annamalai N Thavasi R Jayalakshmi S | | 0，，03： | 1 |
| 20 | Structure and mechanisms of South Indian Ocean climate variability显示文摘 | Xie S P Annamalai H Schott F A | 2002 | J Climate2002，15，： | 1 |
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