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| 1 | Colorectal cancer biomarkers: To be or not to be? Cautionary tales from a road well travelled显示文摘Colorectal cancer(CRC)is the second most common cause of cancer-related death worldwide and places a major economic burden on the global health care system.The time frame for development from premalignant to malignant disease typically spans 10-15 years,and this latent period provides an ideal opportunity for early detection and intervention to improve patient outcomes.Currently,early diagnosis of CRC is hampered by a lack of suitable non-invasive biomarkers that are clinically or economically acceptable for populationbased screening.New blood-based protein biomarkers for early detection of CRC are therefore urgently required.The success of clinical biomarker discovery and validation studies is critically dependent on understanding and adjusting for potential experimental,analytical,and biological factors that can interfere with the robust interpretation of results.In this review we outline some important considerations for research groups undertaking biomarker research with exemplars from our studies.Implementation of experimental strategies to minimise the potential effects of these problems will facilitate the identification of panels of biomarkers with the sensitivity and specificity required for the development of successful tests for the early detection and surveillance of CRC. | Kim YC Fung Edouard Nice Ilka Priebe Damien Belobrajdic Aloke Phatak Leanne Purins Bruce Tabor Celine Pompeia Trevor Lockett Timothy E Adams Antony Burgess Leah Cosgrove | 2014 | World Journal of Gastroenterology2014，20，4： | 2 |
| 2 | Application of Taguchi's robust parameter design methodology for process improve- ment显示文摘 | Antony J Mazharsolook E Kaye M | 1996 | Quality World1996，，： | 1 |
| 3 | Toxicity and Repellency of Hot Pepper Extracts to Spider Mite显示文摘 | ANTONIOUS G F MEYER J E SNYDER J C | 2006 | Journal of Environmental Science and Health-part B Pesticides Food Contaminants and Agricultural Wastes2006，41，8： | 1 |
| 4 | Cooper degradation of misfolded proteins prevents ER-derived oxidative stress and cell death显示文摘 | Haynes C M Titus E A Antony A | 2004 | Molecular Cell2004，15，： | 1 |
| 5 | Trans- forming growth factor-beta2 suppresses collagen cleavage in cultured human osteoarthritic cartilage, reduces expression of genes associated with chondrocyte hypertrophy and degradation, and increases prostaglandin E (2) production 显示文摘 | TCHETINA E V ANTONIOU J TANZER M | 2006 | Am J Pathol2006，168，1： | 1 |
| 6 | A comprehensive Bayesian approach for model updating and quantification of modeling errors 显示文摘 | Zhang E L Feissel P Antoni J | 2011 | Probabilistic Engineering Me- chanics2011，26，4： | 1 |
| 7 | Growing Hot Pepper for Cabbage Looper, Trichopulsia ni (Hubner) and Spidermite, Tetranychus urticae (Koch) Control显示文摘 | ANTONIOUS G F MEYER J E ROGERS J A | 2007 | Journal of Environmental Science and Health-part B Pesticides Food Contaminants and Agricultural Wastes2007，42，5： | 1 |
| 8 | Failureprediction for a glass/epoxy cruciorm specimen under static biaxial loading 显示文摘 | Antoniou A E van Hemelrijck D Philippidis T P | 2010 | Composites Science and Technology2010，70，8： | 1 |
| 9 | Docosahexaenoic Acid Supplementation during Pregnancy: A Potential Tool to Prevent Membrane Rapture and Preterm Labor 显示文摘 | Piell'antoni E Del Chierico F Rigon G | 2014 | Int J Mol Sci2014，15，5： | 1 |
| 10 | Safety and efficacy Of low-dose bexarotene and PUVA in the treatment of patients with mycosis fungoides 显示文摘 | Papadavid E Antoniou C Nikolmu V | 2008 | Am J Clin Dermatol2008，9，3： | 1 |
| 11 | Major complications and transfusion rates after hemiarthroplasty and total hip arthroplasty for femoral neck fractures 显示文摘 | Liodakis E Antoniou J Zukor D J | 2016 | J Arthroplasty2016，31，9： | 1 |
| 12 | Applying multimedia computer-assisted instruction to enhance physical education students ' lcnawledge of 6asketlrall rules 显示文摘 | ANTONIOU P DERRI V KIAUMOURTZOGLOU E | 2003 | European Journal of Physical Education2003，8，1： | 1 |
| 13 | Testicular gene expression in male mice divergent for fertility after heat stress显示文摘 | CAMMACK K M ANTONIOU E HEARNE L | | 0，，： | 1 |
| 14 | Trans- forming growth factor-beta2 suppresses collagen cleavage in cultured human osteoarthritic cartilage, reduces expression of genes associated with chondrocyte hypertrophy and degradation, and increases prostaglandin E (2) production 显示文摘 | TCHETINA E V ANTONIOU J TANZER M | 2006 | Am J Pathol2006，168，1： | 1 |
| 15 | Teaching differences of the relaxation technique between traditional teaching and the one by means of computer显示文摘 | ANTONIOU P THEODORAKIS Y KIOUMOURTZOGLOU E | 1999 | Ezercise & Society1999，，38： | 1 |
| 16 | Transforming growth factor-beta2 suppresses collagen cleavage in cultured human os- teoarthritic cartilage, reduces expression of genes associated with chondrocyte hypertrophy and degradation, and increases prosta- glandin E ( 2 ) production 显示文摘 | Tchetina E A Antoniou J Tanzer M | 2006 | Am J Pathol2006，168，1： | 1 |
| 17 | Small cell lung cancer in never smokers: report of 2 cases显示文摘 | Antony GK Bertino E Franklin M | 2010 | J Thorac Oncol2010，5，： | 1 |
| 18 | The outcome of patients with advanced pure squamous or mixed squamous and transitional urothelial carcinomas following platinum -based chemotherapy显示文摘 | Kastritis E Dimopoulos M A Antoniou N | 2006 | Anticancer Res2006，26，5： | 1 |
| 19 | Toxicological and gene expression analysis of the impact of aflatoxin Bt on hepatic function of male broiler chicks显示文摘 | Yarru L P Settivari R S Antoniou E | 2009 | Poult Sci2009，88，2： | 1 |
| 20 | Smart Phones,a Powerful Tool in the Chemistry Classroom显示文摘 | Williams Antony J Pence Harry E | 2011 | JOURNAL OF CHEMICAL EDUCATION2011，88，6： | 1 |
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