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| 1 | The importance of avoiding unnecessary right ventricular pacing in clinical practice显示文摘Symptomatic bradycardia is effectively treated with the implantation of a cardiac pacemaker. Although a highly successful therapy, during recent years there has been a focus on the negative effects associated with longterm pacing of the apex of the right ventricle(RV). It has been shown in both experimental and clinical studies that RV pacing leads to ventricular dyssynchrony, similar to that of left bundle branch block, with subsequent detrimental effects on cardiac structure and function, and in some cases adverse clinical outcomes such as atrial fibrillation, heart failure and death. There is substantial evidence that patients with reduced left ventricular function(LVEF) are at particular high risk of suffering the detrimental clinical effects of long-term RV pacing. The evidence is, however, incomplete, coming largely from subanalyses of pacemaker and implantable cardiac defibrillator studies. In this group of patients with reduced LVEF and an expected high amount of RV pacing, biventricular pacing(cardiac resynchronization therapy) devices can prevent the negative effects of RV pacing and reduce ventricular dyssynchrony. Therefore, cardiac resynchronization therapy has emerged as an attractive option with promising results and more clinical studies are underway. Furthermore, specific pacemaker algorithms, which minimize RV pacing, can also reduce the negative effects of RV stimulation on cardiac function and may prevent clinical deterioration. | Finn Akerstrm Miguel A Arias Marta Pachón Jesús Jiménez-López Alberto Puchol Justo Juliá-Calvo | 2013 | World Journal of Cardiology2013，5，11： | 3 |
| 2 | Preparation and Characterization of Flexible, Transparent and Thermally Stable Aromatic Co-polyamides显示文摘Two aromatic co-polyamides were synthesized combining two diacid monomers containing bulky pendant groups, 5-(9,10-dihydro-9,10-ethanoanthracene-11,12-dicarboximido)isophthalic acid(DEAIA) and 5-tert-butylisophthalic acid(TERT), with 4,4′-(hexafluoroisopropylidene)dianiline(HFA) or 2,3,5,6-tetramethyl-1,4-phenylenediamine(Durene) by direct polycondensation. The structures of the obtained aromatic co-polyamides were confirmed by FTIR, Raman and 1 H-NMR. The co-copolyamide films, DHTH and DDTD, exhibited rms-roughness values between 0.94 and 1.60 nm, respectively. Moreover, they presented good thermal stability up to300 °C. Young's moduli of the co-polyamide films were between 4.1 and 4.3 GPa. X-ray diffraction results showed that the co-polyamide films were amorphous due to the incorporation of both bulky pendant groups, tert-butyl and dibenzobarrelene. The combination of bulky pendant groups provided intrinsically transparent co-polyamide films with a transmittance higher than 88% in the range of 400-780 nm.Due to these outstanding film and optical properties, they are suggested to be flexible substrates in applications for solar cell and other portable electronic devices. | José Antonio Tec-Sánchez Andrés Iván Oliva Arias Manuel Aguilar-Vega Juan Valerio Cauich-Rodríguez José Luis Santiago-García | 2019 | Chinese Journal of Polymer Science2019，37，2： | 3 |
| 3 | Subcutaneous implantable defibrillator: State-of-the art 2013显示文摘The subcutaneous implantable cardioverter-defibrillator(S-ICD)has recently been approved for commercial use in Europe,New Zealand and the United States.It is comprised of a pulse generator,placed subcutaneously in a left lateral position,and a parasternal subcutaneous lead-electrode with two sensing electrodes separated by a shocking coil.Being an entirely subcutaneous system it avoids important periprocedural and long-term complications associated with transvenous implantable cardioverter-defibrillator(TV-ICD)systems as well as the need for fluoroscopy during implant surgery.Suitable candidates include pediatric patients with congenital heart disease that limits intracavitary lead placements,those with obstructed venous access,chronic indwelling catheters or high infection risk,as well as young patients with electrical heart disease(e.g.,Brugada Syndrome,long QT syndrome,and hypertrophic cardiomyopathy).Nevertheless,given the absence of intracavitary leads,the S-ICD is unable to offer pacing(apart from shortterm post-shock pacing).It is therefore not suitable in patients with an indication for antibradycardia pacing or cardiac resynchronization therapy,or with a history of repetitive monomorphic ventricular tachycardia that would benefit from antitachycardia pacing.Current data from initial clinical studies and post-commercialization'real-life'case series,including over 700 patients,have so far been promising and shown that the S-ICD successfully converts induced and spontaneous ventricular tachycardia/ventricular fibrillation episodes with associated complication and inappropriate shock rates similar to that of TV-ICDs.Furthermore,by using far-field electrograms better tachyarrhythmia discrimination when compared to TV-ICDs has been reported.Future results from ongoing clinical studies will determine the S-ICD system’s long-term performance,and better define suitable patient profiles. | Finn Akerstrm Miguel A Arias Marta Pachón Alberto Puchol Jesús Jiménez-Lópezl | 2013 | World Journal of Cardiology2013，5，9： | 2 |
| 4 | Prophylaxis with ketotifen in rats with portal hypertension:involvement of mast cell and eicosanoids显示文摘BACKGROUND:Since we have previously shown an increase of mast cells in the small bowel and in the mesenteric lymph nodes in the rats with prehepatic portal hypertension,it can be hypothesized that this essential inflammatory cell would be involved in the pathogeny of the splanchnic changes related to portal hypertension. METHODS:To verify this hypothesis,we first studied mast cell infiltration in the ileum and in the mesenteric lymph nodes in sham-operated male Wistar rats(n=12) and in short-term prehepatic portal hypertensive rats (n=12),and the serum levels of rat mast cell protease Ⅱ(RMCP-Ⅱ)by ELISA.In a second set of experiments ketotifen,a mast cell stabilizer drug,was administered to sham-operated(n=10)and portal hypertensive(n=12) rats 24 hours before the intervention and prostanoids (PGE2,PGI2,TXB2)and leukotrienes(LTC4,LTB4)were assayed by RIA,mast cell infiltration in the ileum and in the mesenteric lymph nodes and the serum levels of RMCP-Ⅱwere also studied,to show its effectiveness to prevent the mesenteric alterations produced by the inflammatory mediators released by the mast cell. RESULTS:Forty-eight hours after the intervention RMCP-Ⅱ (P<0.05),PGE2(P<0.001)and LTC4 serum levels decreased and mast cell number and RMCP-Ⅱlevels increased in mesenteric lymph nodes in portal hypertensive rats.Prophylactic administration of ketotifen reduced portal pressure(P<0.001),serum levels of PGE2(P<0.001)and RMCP-Ⅱ(P<0.001)in mesenteric lymph nodes. CONCLUSIONS:In acute portal hypertension in the rat,the mast cell translocation from intestinal mucosa to mesenteric lymph nodes,where they are activated and degranulates,would represent a defence mechanism to avoid the activation of an acute and massive inflammatory response in this location.Prophylactic administration of ketotifen is able to reduce the splanchnic inflammatory changes related to acute portal hypertension in the rat. | Fernando Sánchez-Patán Raquel Anchuelo Elena Vara Cruz García Yolanoa Saavedra Patri Vergara Carmen Cuellar Marta Rodero Maria-Angeles Aller Jaime Arias | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 2 |
| 5 | Clay swelling and formation permeability reductions induced by a nonionic surfactant 显示文摘 | Gardner K H Arias M S | 2000 | Environ Sci Technol2000，34，1： | 2 |
| 6 | Efficacy of Dietary Interventions in Inducing Histologic Remission in Patients with Eosinophilic Esophagitis: a Systematic Review and Meta-analysis显示文摘 | ángel Arias Jesús González-Cervera José M. Tenias Alfredo J. Lucendo | 2014 | Gastroenterology2014，，： | 2 |
| 7 | Hepatic lipid metabolism changes in short-and long-term prehepatic portal hypertensive rats显示文摘AIM: To verify the impairment of the hepatic lipid metabolism in prehepatic portal hypertension. METHODS: The concentrations of free fatty acids, diacylglycerol, triglycerides, and phospholipids were assayed by using D-[U-14C] glucose incorporation in the different lipid fractions and thin-layer chromatography and cholesterol was measured by spectrophotometry, in liver samples of Wistar rats with partial portal vein ligation at short- (1 mo) and long-term (1 year) (i.e. portal hypertensive rats) and the control rats. RESULTS: In the portal hypertensive rats, liver phospholipid synthesis significantly decreased (7.42 ± 0.50 vs 4.70 ± 0.44 nCi/g protein; P < 0.01) and was associated with an increased synthesis of free fatty acids (2.08 ± 0.14 vs 3.36 ± 0.33 nCi/g protein; P < 0.05), diacylglycerol (1.93 ± 0.2 vs 2.26 ± 0.28 nCi/g protein), triglycerides (2.40 ± 0.30 vs 4.49 ± 0.15 nCi/g protein) and cholesterol (24.28 ± 2.12 vs 57.66 ± 3.26 mg/g protein; P < 0.01). CONCLUSION: Prehepatic portal hypertension in rats impairs the liver lipid metabolism. This impairment consists in an increase in lipid deposits (triglycerides,diacylglycerol and cholesterol) in the liver, accompanied by a decrease in phospholipid synthesis. | Maria-Angeles Aller Elena Vara Cruz García Maria-Paz Nava Alejandra Angulo Fernando Sánchez-Patán Ana Calderón Patri Vergara Jaime Arias | 2006 | World Journal of Gastroenterology2006，12，42： | 2 |
| 8 | Clay swelling and formation permeability reductions induced by a nonionic surfactant显示文摘 | GARDNER K H ARIAS M S | 2000 | Environ Sci Technol2000，34，： | 1 |
| 9 | Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss 显示文摘 | Laferr~re B Reilly D Arias S | 2011 | Sei Transl Med2011，3，80： | 1 |
| 10 | Reactive oxygen species sources and biomolecular oxidative damage induced by aflatoxin B1and fumonisin B1 in rat spleen mononuclear cells显示文摘 | MARY V S THEUMER M G ARIAS S L | 2012 | Toxicology2012，，23： | 1 |
| 11 | Muskmelon fruit soluble acid invertase and sucrose phosphate synthase activity and polypeptide profiles during growth and maturation显示文摘 | LESTER G E ARIAS L S L LIM M G | 2001 | J Amer Soc Hort Sci2001，126，： | 1 |
| 12 | Autophagy in hypothalamic AgRP neurons regulates food intake and energy bal- ance显示文摘 | Kaushik S Rodriguez-Navarro JA Arias E | 2011 | Cell Metab2011，14，2： | 1 |
| 13 | Phylogenetic Relationships of Honey Bees (Hymenoptera: Apinae: Apini) Inferred from Nuclear and Mitochondrial DNA Sequence Data 显示文摘 | Arias M C Sheppard W S | 2005 | Molecular Phytogenetics and Evolution2005，37，1： | 1 |
| 14 | IntervertebraI disc degeneration in relation to the COL9A3 and the IL-1B gene polymorphisms显示文摘 | Solovieva S Lohiniva J Leino Arias P Raininko R Luoma K Ala Kokko L | 2006 | EurSpine J2006，15，： | 1 |
| 15 | Strain-and matrix-dependent adhesion of Lactobacillus plantarum is mediated by proteinaceous bacterial compounds显示文摘 | Tallon R Arias S Bressollier P | 2007 | Journal of Applied Microbiology2007，102，2： | 1 |
| 16 | Digestibility of forage silages from grain, sweet and bmr sorghum types:Comparison of in vivo, in situ and in vitro data显示文摘 | Marcoa O N Ressia M A Arias S | 2009 | Animal Feed Science and Technology2009，153，： | 1 |
| 17 | Mesoscale power generation by a catalytic combustor using electrosprayed liquid hydrocarbons 显示文摘 | Kyritsis D C Arias I G Roychoudhury S | 2002 | Proceedings of the Combustion Institute2002，29，1： | 1 |
| 18 | Clinical evaluation of themicroscopic observation drug susceptibility assay for detection ofMycobacterium tuberculosis resistance to isoniazid or rifampin显示文摘 | Mello FC Arias MS Rosales S | 2007 | J Clin Microbiol2007，45，： | 1 |
| 19 | Genetic basis for in vivo daptomycin resistance in enterococci显示文摘 | Arias CA Panesso D McGrath DM Qin X Mojica MF Miller C Diaz L Tran TT Rincon S Barbu EM Reyes J Roh JH Lobos E Sodergren E Pasqualini R Arap W Quinn JP Shamoo Y Murray BE Weinstock GM | | 0，，： | 1 |
| 20 | Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic lin- ezolid显示文摘 | Toh S M Xiong L Arias C A et at | 2007 | Mol Microbiol2007，64，6： | 1 |
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