|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 2 | Electrophoretic, solubility, and functional properties of commercial soy protein isolartes 显示文摘 | Arrese E L Sorgentini D A Wagner J R Anon M C | 1991 | Journal of Agricultural and Food Chemistry1991，39，： | 1 |
| 3 | The metabolic syn- dro me:from anaggravating condition to a pathogenic risk factor for chronic diseases 显示文摘 | Von Bernhardi R Zanlungo S Arrese M | 2010 | Rev M ed Chil2010，138，8： | 1 |
| 4 | Maternal cholestasis does not affect the ontogenic pattern of expression of the Na^+/taurocholate cotransporting polypeptide (ntcp) in the fetal and neonatal rat and neonatal rat liver显示文摘 | Arrese M Trauner M Boyer J L | 1998 | Hepatology1998，28，3： | 1 |
| 5 | Risk of non‐alcoholic fatty liver disease in patients with psoriasis: a systematic review and meta‐analysis显示文摘 | R. Candia A. Ruiz R. Torres‐Robles N. Chávez‐Tapia N. Méndez‐Sánchez M. Arrese | 2015 | J Eur Acad Dermatol Venereol2015，，： | 1 |
| 6 | Burning hepatic fat:therapeutic potential for fiver- specific thyromimetics in the treatment of nonalcoholic fatty liver disease显示文摘 | Arrese M | 2009 | Hepatology2009，49，2： | 1 |
| 7 | Nonalcoholic fatty liver disease, liver disease: an overlooked complication of diabetes mellitus 显示文摘 | Arrese M | 2010 | Nat Rev Endocrinol2010，6，12： | 1 |
| 8 | Cholestasis during pregnancy:rare hepatic diseases unmasked by pregnancy显示文摘 | Arrese M | 2006 | Ann Hepatol2006，5，： | 1 |
| 9 | Molecular pathogenesis of intrahepatic cholestasis of pregnancy显示文摘 | Arrese M Macias RI Briz O | 2008 | Expert Rev Mol Med2008，10，3： | 1 |
| 10 | Hepatobiliary trans- port: molecular mechanisms of development and cholestasis显示文摘 | Arrese M Ananthananarayanan M Suchy F J | 1998 | Pe- diatr Res1998，44，2： | 1 |
| 11 | The metabolicsyn- drome: from an aggravating condition to a pathogenicfisk factor for chronic diseases显示文摘 | Yon Bemhardi R Zanlungo S Arrese M | 2010 | Rev Med Chil2010，138，8： | 1 |
| 12 | Molecular aspects of bile formation and cholestasis显示文摘 | Arrese M Trauner M | 2003 | Trends Mol Med2003，9，12： | 1 |
| 13 | Endotoxin do,snregulates rat he- patic ntcp gene expression via decreased activity of critical tran- scription factm's显示文摘 | Trauner M Arrese M Lee H | 1998 | J Clin Invest1998，101，10： | 1 |
| 14 | The rat canalicular conjugated export pump(Mrp2) is down-regulated in intrahepatic and obstructive cholestasis显示文摘 | Tranuner M Arrese M Soroka C J | 1997 | Gastroenterology1997，113，1： | 1 |
| 15 | Intrahepatic cholestasis of pregnancy : a past and present fiddle 显示文摘 | Arrese M Reyes H | 2006 | Ann Hepatol2006，5，3： | 1 |
| 16 | Current con- cepts in the pathogenesis of nonalcoholic fatty liver disease显示文摘 | Mendez - Sanchez N Arrese M Zamora - Valdes D | 2007 | Liver Int2007，27，4： | 1 |
| 17 | Intrahepatie eholestasis of pregnancy: a past and persent riddle显示文摘 | Arrese M Reyes H | 2006 | Ann Hepatal2006，5，3： | 1 |
| 18 | Molecular pathogenesis of intrahepatic cholestasis of pregnancy显示文摘 | Arrese M Macias RI Briz O | 2008 | Expert Rev Mol Med2008，10，： | 1 |
| 19 | Molecular pathogenesis of intra- hepatic cholestasis of pregnancy显示文摘 | Arrese M Macias RI Briz O | 2008 | Expert Rev Mol Med2008，10，： | 1 |
| 20 | The bile salt export pump : molecular Properties, function and regulation 显示文摘 | Arrese M Ananthanarayanan M | 2004 | Pflugers Arch2004，449，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员