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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Fatty liver in hepatitis C patients post-sustained virological response with direct-acting antivirals显示文摘AIM To determine steatosis and fibrosis prevalence in hepatitis C patients after a sustained virological response achieved with direct-acting antivirals.METHODS Transient elastography with controlled attenuation parameter(CAP) was used to assess hepatic steatosis post-sustained virological response(SVR);the CAP technology was not available in the United States at study initiation.Liver stiffness/fibrosis was measured before and 47 wk after treatment completion.Patients with genotype 3 and patients with cirrhosis were excluded.RESULTS One hundred and one patients were included in the study.Post-SVR there were decreases from baseline in alanine aminotransferase(ALT)(63.1 to 17.8 U/L),aspartate aminotransferase(51.8 to 21.5 U/L) and fibrosis score(7.4 to 6.1 k Pa)(P < 0.05).Post-SVR,48 patients(47.5%) had steatosis on CAP;of these,6.25% had advanced fibrosis.Patients with steatosis had higher body mass index(29.0 vs 26.1 kg/m2),glucose(107.8 vs 96.6 mg/d L),ALT(20.4 vs 15.3 mg/d L),CAP score(296.3 vs 212.4 d B/m) and fibrosis score(7.0 vs 5.3 k Pa);P < 0.05.Interestingly,compared to baseline,both patients with and without steatosis had change in fibrosis score post-SVR(7.7 k Pa vs 7.0 k Pa and 7.0 k Pa vs 5.3 k Pa);alternatively,(P < 0.05) and therefore patients with steatosis continued to have clinically significant stiffness(≥ 7 k Pa).CONCLUSION Fatty liver is very common in hepatitis C virus(HCV) patients post-SVR.These patients continue to have elevated mean fibrosis score(≥ 7 k Pa) compared to those without fatty liver;some have advanced fibrosis.Long term follow up is needed to assess steatosis and fibrosis in HCV patients post-SVR. | Mazen Noureddin Micaela M Wong Tsuyoshi Todo Shelly C Lu Arun J Sanyal Edward A Mena | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 3 | Climate change adaptation, greenhouse gas mitigation and economic profitability of conservation agriculture: Some examples from cereal systems of Indo-Gangetic Plains显示文摘Achieving sustainability of the cereal system in the Indo-Gangetic Plains(IGP)of India under progressive climate change and variability necessitates adoption of practices and technologies that increase food production,adaptation and mitigation in a sustainable way.This paper examines conservation agriculture(CA)from the perspective of:(i)increased yield and farm income,(ii)adaptation to heat and water stresses,and(iii)reduction in greenhouse gas(GHGs)emissions.The analyses and conclusions are based on the literature and evidences from a large number of on-station as well as farmers’field trials on CA in the cereal systems of IGP.Our analyses show that CA-based system substantially reduces the production cost(up to 23%)but produces equal or even higher than conventional system;thereby increasing economic profitability of production system.CA-based production systems also moderated the effect of high temperature(reduced canopy temperature by 1–4°C)and increased irrigation water productivity by 66–100%compared to traditional production systems thus well adapting to water and heat stress situations of IGP.Our continuous monitoring of soil flux of CO2,N2O and CH4 revealed that CA-based rice-wheat systems emit 10–15%less GHGs than conventional systems.This is the first time that CA and its components are synthesized and analyzed from food security-climate change nexus.From this holistic analysis,we suggest that wide-scale promotion of suitable CA practices by integrating into national agriculture development strategy is a way forward to address food security,climate change adaptation and mitigation challenges faced by present agriculture. | Tek B Sapkota M L Jat Jeetendra P Aryal R K Jat Arun Khatri-Chhetri | 2015 | Journal of Integrative Agriculture2015，14，8： | 4 |
| 4 | Congenital diarrhea in a newborn infant: A case report显示文摘BACKGROUND Microvillus inclusion disease(MVID)is a rare autosomal recessive cause of severe congenital diarrhea with significant morbidity and mortality.Definitive treatment involves bowel transplant.The diagnosis of this condition can be challenging and a few genetic panels are available for the identification of the most common mutations.We present the case of an infant with MVID due to a mutation not reported in the literature before.CASE SUMMARY We report the case of an infant transferred to our institution with severe diarrhea of unknown etiology,failure to thrive,and significant metabolic derangements.An extensive work-up including stool studies for common gastrointestinal pathogens,abdominal ultrasound,esophagogastroduodenoscopy with duodenal biopsy and flexible sigmoidoscopy failed to reveal a diagnosis.Multiple dietary and formula regimens were introduced but all resulted in voluminous diarrhea.She remained on total parenteral nutrition(TPN)for the duration of her hospital stay.Genetic testing was done and she was subsequently found to have a novel mutation in the MYO5B gene[homozygous mutation for MYO5B c.1462del,p.(Ile488Leufs*93)]giving us the diagnosis of MVID.She remains on TPN while awaiting bowel transplant at the time of the compilation of this case report.CONCLUSION We report a novel mutation involved in MVID and highlight the importance of considering this disease when faced with a newborn presenting with life threatening diarrhea.At the time of this publication,232 allelic variations of this gene(MIM#606540)exist in National Center for Biotechnology Information’s database.Our patient’s mutation has not been reported in literature as a cause of MVID. | Mehrin Sadiq Omer Choudry Arun K Kashyap Danitza M Velazquez | 2019 | World Journal of Clinical Pediatrics2019，8，3： | 3 |
| 5 | Economic incentives for agricultural nonpoint source pollution control显示文摘 | Bruce A L Marc R | 1994 | Water Resources Bulletin1994，30，3： | 1 |
| 6 | Control of macro-micro manipulators revisited显示文摘 | PARSA K ANGELES J ARUN K M | 2005 | Journal of Dynamic Systems Measurement and Control Transactions of the ASME2005，127，4： | 1 |
| 7 | Browning of fresh-cut eggplant: impact of cutting and storage显示文摘 | BIBHUTI B M SATYENDRA G ARUN S | 2012 | Postharvest Biology and Technology2012，67，： | 1 |
| 8 | Studies on physicochemical characteristics of chitosan derivatives with dicarboxylic acids显示文摘 | Arun Ghosh M Azam Ali | 2012 | Journal of Materials Science2012，47，3： | 1 |
| 9 | Endothelin-1 is a novel prognostic factor in non-small cell lung cancer显示文摘 | Arun C De Catris M Hemingway DM | 2004 | Int J Biol Markers2004，19，4： | 1 |
| 10 | CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancer显示文摘 | Cabioglu N Yazici M S Arun B | 2005 | Clin Cancer Res2005，11，16： | 1 |
| 11 | The business value of digital supply networks: a program of re- search on the impacts of globalization 显示文摘 | Jonathan W Areham Lars M Athiassen Arun Rai | 2005 | Journal of Interna- tional Management2005，，11： | 1 |
| 12 | Visualization of three dimensional pore morphologies in a high-pressure die-cast Mg Al RE alloy显示文摘 | SOON G L ARUN M G | 2007 | Scrip ta Materialia2007，56，501： | 1 |
| 13 | Fabrication,Characterization and Dynamic Behavior of Polyester/TiO2 Nanocomposites显示文摘 | Evora Victor M F Shukla Arun | 2003 | Materials Science and Engineering A2003，25，12： | 1 |
| 14 | Direct electron transfer with yeast cells and construction of a mediatorless microbial fuel cell 显示文摘 | Prasad D Arun S Murugesan M | 2007 | Biosensors and Bio- electronics2007，12，： | 1 |
| 15 | Detecting accidental contaminations in municipal water networks: dis-cussion 显示文摘 | Kumar Arun Kansal M L Arora Geeta | 1999 | J Water Resour Plan Manage1999，125，5： | 1 |
| 16 | Nuclear NF-κB p65 Phos-phorylationat Serine 276 by Protein KinaseA Contributes to the MalignantPhenotype of Head and Neck Cancer显示文摘 | ARUN P BROWN M B EHSANIAN R | 2009 | Clin Cancer Res2009，15，： | 1 |
| 17 | QROCK: a quick version of the ROCK algorithm for clustering of cate- gorical data 显示文摘 | Dutta M Dakoti Mahanto A Pujari Arun K | 2005 | Pattern Recognition Letters2005，26，15： | 1 |
| 18 | An efficient reverse auction mechanism for limited supplier base显示文摘 | Arun K R Mamata J Pratap K J M | 2011 | Electronic Commerce Research and Applications2011，10，2： | 1 |
| 19 | Structure-based design: synthesis and biological evaluation of a series of novel cycloamide- derived HIV-1 protease inhibitors 显示文摘 | Arun K Ghosh Lisa M Swanson Hanna Cho Sofiya Leshehenko Khaja Azhar Hussain Stephanie Kay D Eric Walters Yasuhiro Koh Hiroaki Mitsuya | 2005 | Journal of medicinal chemistry2005，48，10： | 1 |
| 20 | Carcinoma of the gallbladder显示文摘 | SANJEEV M ARUN C NARESH CM | 2003 | The Lancet Oncology2003，4，2： | 1 |
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