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| 1 | ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10(ABCC1O) are not primary resistance factors for cabazitaxel显示文摘Introduction:ATP-binding cassette subfamily B member 1(ABCB1) and subfamily C member 10(ABCCIO) proteins are efflux transporters that couple the energy derived from ATP hydrolysis to the translocation of toxic substances and chemotherapeutic drugs out of cells.Cabazitaxel is a novel taxane that differs from paclitaxel by its lower affinity for ATP-binding cassette(ABC) transporters.Methods:We determined the effects of cabazitaxel,a novel tubulin-binding taxane,and paclitaxel on paclitaxelresistant,ABCB1-overexpressing KB-C2 and LLC-MDR1-WT cells and paclitaxel-resistant,ABCC10-overexpressing HEK293/ABCC10 cells by calculating the degree of drug resistance and measuring ATPase activity of the ABCB1 transporter.Results:Decreased resistance to cabazitaxel compared with paclitaxel was observed in KB-C2,LLC-MDR1-WT,and HEK293/ABCC10 cells.Moreover,cabazitaxel had low efficacy,whereas paclitaxel had high efficacy in stimulating the ATPase activity of ABCB1,indicating a direct interaction of both drugs with the transporter.Conclusion:ABCB1 and ABCC10 are not primary resistance factors for cabazitaxel compared with paclitaxel,suggesting that cabazitaxel may have a low affinity for these efflux transporters. | Rishil J Kathawala Yi-Jun Wang Suneet Shukla Yun-Kai Zhang Saeed Alqahtani Amal Kaddoumi Suresh V Ambudkar Charles R Ashby Jr Zhe-Sheng Chen | 2015 | Chinese Journal of Cancer2015，34，3： | 4 |
| 2 | Antimicrobial resistance in Gram-positive pathogens isolated in the UK between October 1996 and January 1997显示文摘 | Andrews J Ashby J Jevons G | 1999 | J Antimicrob Chemother1999，43，： | 1 |
| 3 | The effect on sperm production in adult Sprague-Dawley rats exposed by gavage to bisphenol A between postnatal days 91-97显示文摘 | Ashby J Tinwell H Lefevre PA | 2003 | Toxicol Sci2003，74，： | 1 |
| 4 | High vacuum DTA-TGA instrumentation for air-sensitive compounds显示文摘 | ASHBY E C CLAUDY P BOUQUET J | 1975 | Journal of Chemical Education1975，52，9： | 1 |
| 5 | Diagrams for laser materials processing显示文摘 | Ion J C Shercliff H R Ashby M F | 1992 | Acta Metall Mater1992，40，7： | 1 |
| 6 | The mechanics of two-dimensional cellular materials 显示文摘 | GIBSON L J ASHBY M F SCHAJER G S | 1982 | Proceedings of the Royal Society of London(A)1982，382，： | 1 |
| 7 | Sound absorption in metallic foams 显示文摘 | Lu T J Hess A Ashby M F | 1999 | Journal of Applied Physics1999，85，11： | 1 |
| 8 | Multi-functionality of cellular metal systems显示文摘 | Evan A G Hutchinson J W Ashby N F | 1999 | Progress in Materials Science1999，43，： | 1 |
| 9 | Self-esteem as a mediator between perfectionism and depression: A structural equations analysis 显示文摘 | Riee K G Ashby J S Slaney R | 1998 | Journal of Counseling Psychology1998，45，： | 1 |
| 10 | A numerical investigation of conjugate gradient method as applied to three-dimensional groundwater flow problem in randomly heterogeneous porous media显示文摘 | Meyer P D Valocchi A J Ashby S F | 1989 | Water Resources Research1989，25，6： | 1 |
| 11 | The role of the GluR2 sub- unit in AMPA receptor function and synaptic plasticity 显示文摘 | ISAAC J T ASHBY M C MCBAIN C J | 2007 | Neuron2007，54，6： | 1 |
| 12 | Evaluation of the potential carcinogenicity and genetic toxicity to hu mans of the herbicide acetochlor显示文摘 | Ashby J Kier L Wilson A G E | 1996 | Human&experimental toxicology1996，15，9： | 1 |
| 13 | Failure surfaces for cellular materials under multi-axial loads-(I) modeling 显示文摘 | Gibson L J Ashby M F Zhang J Triantafiliou T C | 1989 | International Journal of Mechanical Sciences1989，31，9： | 1 |
| 14 | Studies of the Genetoxicity of Beryllium Sulfate In Vitro and Vivo显示文摘 | Ashby J | 1990 | Mutation Research1990，240，3： | 1 |
| 15 | Effectiveness of ECT combined with risperidone against aggression in schizo- phrenia 显示文摘 | Shigehiro Hirose Charles R Ashby Ma-rko J | 2008 | The Journal of ECT2008，17，1： | 1 |
| 16 | Biogeochemistry of microbial coal-bed methane 显示文摘 | Str?po? D Mastalerz M Dawson K Macalady J Callaghan AV Wawrik B Turich C Ashby M | 2011 | Annu Rev Earth Planet Sci2011，39，： | 1 |
| 17 | Exposure to peroxisome proliferactors: reassessment of the potential carcinogenic hazard显示文摘 | Roberts R Moffat G Ashby J | 2001 | Environmental Health Perspectives2001，109，10： | 1 |
| 18 | Contribution of the P2Y12receptor-mediated pathway to platelet hyperreactivity in hypercholesterolemia显示文摘 | Nagy B Jr Jin J Ashby B | 2011 | J Thromb Haemost2011，9，4： | 1 |
| 19 | Heat Transfer in Open- Cell Metal Foams 显示文摘 | Lu T J Stone H A Ashby M F | 1998 | Acta Materialia1998，46，： | 1 |
| 20 | Genetic toxicity and potential carcinogenicity of paclitaxel 显示文摘 | Tinwell H Ashby J | 1994 | Carcinogenesis1994，15，8： | 1 |
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