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115篇 您的检索式:作者名="ASHCROFT A"
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1BMC Medicine论文摘要汇编——风险预测模型评估的不确定性对治疗决策影响的队列研究:以英国基层医疗机构心血管病患者为例显示文摘背景风险预测模型通常在临床中用于辅助决策。但是,目前很少有研究对于风险预测模型评估超出可信区间(CI)的风险评分的不确定性进行探讨。本文旨在对采用基于QRISK预测工具建立的不同风险预测模型评估的患者发病风险的不确定性进行分析。方法从英国临床研究数据库选取3 792 474例具有住院治疗数据及死亡记录、符合研究要求并可以进行心血管病(CVD)风险评估的患者。采用建立QRISK 2和QRISK 3模型的方法建立风险预测模型(模型A^F),然后校正可能导致各模型预测能力差异的因素以及填补缺失数据后再进行预测。比较各模型的十年风险评分以及一般性能。结果不同模型评估患者CVD风险结果有显著差异。模型A评估男性CVD风险95%CI为(4.4%,16.3%)、女性为(4.6%,15.8%),模型F评估患者CVD风险95%CI为(9%,10%)。一般性能指标评价各模型预测能力相似(Harrell’s C=0.86~0.87)。造成各模型风险预测能力差异最大的因素为CVD发病长期趋势,校正此因素后,女性发病风险预测HR差异可降低0.96(0.95,0.96),男性可降低0.96(0.96,0.96)。当使用模型对英国人群进行风险评估时,有380万人可能被重新归类到符合使用他汀类药物的患者人群。本研究的一个重要局限性是没有纳入CPRD数据库中缺失的可能因素,如饮食或体育活动等。结论基于日常资料对患者CVD发病风险的预测结果因模型而异。尽管各模型预测结果可存在很大的差异,但普通性能指标评价各模型的预测能力相似。在做临床决策时,还应考虑临床评估结果和其他风险因素。对CVD发病长期趋势因素,应做进一步研究。本刊编辑部(整理) PATE A EMSLEY R ASHCROFT D M 2019中国全科医学2019,22,29:2
2Clinical measures of disease severity and outcome in psoriasis:a critical appraisal of their quality显示文摘ASHCROFT D M WAN PO A L WILLIAMS H C 1999Br J Dermatol1999,141,2:1
3Weighted-density-functional theory of inhomogeneous liquids and the freezing transition显示文摘 Ashcroft N W 1985Phys Rev1985,32,:1
4The relation between re- fitted radiation and yield on the broad balk winter wheat experi- ment显示文摘Ashcroft P M Catt J A Curran P J 1990Int J Remote Sensing1990,11,10:1
5The detection and identification of metal and organic pollutants in potable water using enzyme assays suitable for senor development显示文摘Cowell D C Dowman A A Ashcroft T 1995Biosenors and Bioelectronics1995,10,67:1
6Targeting the hypoxia - inducible factor (HIF) pathway in cancer显示文摘POON E HARRIS A L ASHCROFT M 2009Expert Rev Mol Med2009,11,:1
7Structural development and crustal stretching in the Muglad Basin,southern Sudan显示文摘Mohamed A Y Ashcroft W A Whiteman A J 2001Journal of African Earth Sciences2001,32,2:1
8Defective collagen metabolism in Saudi patients with hernia 显示文摘ASHCROFT G S HORAN M A RAFEE A A 1992Ann Clin Bioehem1992,29,3:1
9Partial oxidation of methane to synthesis gas using carbon dioxide显示文摘Ashcroft A Cheetham A Green M 1991Nature1991,352,:1
10Partial oxidation ofmethanetosynthesisgas-usingcarbon-dioxide显示文摘Ashcroft A T Cheetham A K Green M L H 1991Nature1991,352,6332:1
11Fracture mechanics and damage mechanics based fatigue lifetime prediction of adhesively bonded joints subjected to variable amplitude fatigue显示文摘Shenoy V Ashcroft I A Critchlow G W 2010Engineering Fracture Mechanics2010,77,7:1
12Partial oxidation of methane to synthesis gas-using carbon-dioxide显示文摘ASHCROFT A T CHEETHAM A K GREEN M L H VERNON P D F 1991Nature1991,352,6332:1
13Electronic propertiesof the Si/SiO2 interface from first principles显示文摘NEATON J B MULLER D A ASHCROFT N W 2000Phys Rev Lett2000,85,6:1
14Identification of nonsteroidal anti-inflammatory drugs and their metabolites in solid phase extracts of human urine using capillary eleetrophoresis-mass speetrometry显示文摘ASHCROFT A E MAJOR H J 1995Analytical Proeeedings1995,32,11:1
15Characterization of Glass-ceramic to Metal Bonds显示文摘Ashcroft I A Derby B 1994Journal of Material Science1994,29,17:1
16Partial oxidation of methane to synthesis gas using carbon dioxide显示文摘ASHCROFT A T CHEETHAM A K GREEN M L H VERNON P D F 1991Nature1991,352,6332:1
17Selective oxidation of methane to synthesis gas using transition metal catalysts显示文摘Ashcroft A T Cheetham A K Foord J S 1990Nature(London)1990,344,6264:1
18Partial oxidation of methane to synthesis gas using carbon dioxide 显示文摘Ashcroft A T Cheetham A K Green M L H 1991Nature1991,52,:1
19Related Articles, Links Development of a urinary biomarker of human exposure to deoxynivalenol显示文摘Meky F A Turner P C Ashcroft A E 2003Food Chem Toxicol2003,41,26:1
20Modeling petroleum generation in the Southern Muglad rift basin,Sudan显示文摘Mohamed A Y Pearson M J Ashcroft W A 1999AAPG Bulletin1999,83,12:1
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