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| 1 | Role of polyethylene particles in peri-prosthetic osteolysis:A review显示文摘There is convincing evidence that particles produced by the wear of joint prostheses are causal in the periprosthetic loss of bone,or osteolysis,which,if it progresses,leads to the phenomenon of aseptic loosening.It is important to fully understand the biology of this bone loss because it threatens prosthesis survival,and loosened implants can result in peri-prosthetic fracture,which is disastrous for the patient and presents a difficult surgical scenario.The focus of this review is the bioactivity of polyethylene(PE)particles,since there is evidence that these are major players in the development and progression of osteolysis around prostheses which use PE as the bearing surface.The review describes the biological consequences of interaction of PE particles with macrophages,osteoclasts and cells of the osteoblast lineage,including osteocytes.It explores the possible cellular mechanisms of action of PE and seeks to use the findings to date to propose potential nonsurgical treatments for osteolysis.In particular,a nonsurgical approach is likely to be applicable to implants containing newer,highly cross-linked PEs(HXLPEs),for which osteolysis seems to occur with much reduced PE wear compared with conventional PEs.The caveat here is that we know little as yet about the bioactivity of HXLPE particles and addressing this constitutes our next challenge. | Gerald J Atkins David R Haynes Donald W Howie David M Findlay | 2011 | World Journal of Orthopedics2011，2，10： | 11 |
| 2 | Influence of the carrier on the catalytic performance of impregnated phosphoric acid in the hydration of ethylene显示文摘 | atkins M P Wolderich W F | 1999 | Applied catalysis A:general1999，181，1： | 1 |
| 3 | Protection in animal models of brain and spinal cord injury with mild to moderate hypothermia 显示文摘 | DIETRICH W D ATKINS C M Bramlett H M | 2009 | J Neurotranma2009，26，3： | 1 |
| 4 | Information consensus in mul- tivehicle cooperative control: Collective group behavior through lo- cal interaction 显示文摘 | WRen R W Beard E M Atkins | 2007 | IEEE Control Systems Magazine2007，27，2： | 1 |
| 5 | Information consensus in multivehicle cooperative control 显示文摘 | REN W BEARD R W ATKINS E M | 2007 | IEEE Control Systems Maga- zine2007，27，2： | 1 |
| 6 | Distributed multi-vehicle coordinated con- trol via local information exchange显示文摘 | REN W ATKINS E M | 2007 | International Journal of Ro- bust and Nonlinear Control2007，17，1011： | 1 |
| 7 | The impact of a shock wave on porous compressible foams 显示文摘 | Skews B W Atkins M D Seitz M W | 1993 | Journal of Fluid Mechanics1993，253，1： | 1 |
| 8 | A PPAR-FGF1 axis is re- quired for adaptive adipose remodelling and metabolic homeostasis 显示文摘 | Jonker J W Suh J M Atkins A R | 2012 | Nature2012，485，7398： | 1 |
| 9 | The proliferation and phenotypic expression of human osteoblasts on tantalum metal显示文摘 | David M Findlay Katie Welldon Gerald J Atkins Donald W Howie Andrew C.W Zannettino Dennis Bobyn | 2003 | Biomaterials2003，，12： | 1 |
| 10 | Randomized Phase Ⅱ study of multiple does levels of CCI -779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinomas显示文摘 | ATKINS M B HIDALGO M STADLER W M | 2004 | J Clin Oncol2004，22，： | 1 |
| 11 | Randomized phase Ⅱ study of multiple dose levels of CCI - 779, a novel mammalian target of rapamycin kinase inhibitor, in patients with ad- vanced refractory renal cell carcinoma显示文摘 | ATKINS M B HIDALGO M STADLER W M | 2004 | J Clin Oncol2004，22，5： | 1 |
| 12 | Characteristics and outcomes of patients who self- extubate from ventilatory support显示文摘 | Atkins P M Mion L C Mendelson W | 1997 | Chest1997，112，： | 1 |
| 13 | Information consensus in mul-tivehicle cooperative control 显示文摘 | Ren W Beard R W Atkins E M | 2007 | IEEE Control Systems Maga-zine2007，27，2： | 1 |
| 14 | Information consensus in multivehicle cooperative control显示文摘 | Ren W Beard R W Atkins E M | 2007 | IEEE Control Systems Magazine2007，27，2： | 1 |
| 15 | Information consensus in multivehicle cooperative control显示文摘 | REN W BEARD R W ATKINS E M | 2007 | IEEE Control Systems Magazine2007，27，2： | 1 |
| 16 | Prevention of colorectal cancer by once - only sigmoidoscopy 显示文摘 | ATKIN W S ZICK J NORTHOVER J M | 1993 | Lancet1993，341，8847： | 1 |
| 17 | Information consensus in multivehicle cooperative control显示文摘 | Wei Ren Randal W Beard Ella M Atkins | 2007 | IEEE Control Systems Magazine2007，27，2： | 1 |
| 18 | Information consensus in multi vehicle cooperative control显示文摘 | Ren W Beard R W Atkins E M | | 0，，02： | 1 |
| 19 | M otivational interviewing eady after acute stroke: a ran domized , controlled trial 显示文摘 | W atkins CL Auton M F D eans CF | 2007 | Stroke2007，38，3： | 1 |
| 20 | Information consensus in multivehicle cooperative control显示文摘 | REN W BEARD R W ATKINS E M | 2007 | IEEE Control Systems Magazine2007，27，2： | 1 |
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