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| 1 | Interplay between nitric oxide and VIP in CCK-8-induced phasic contractile activity in the rabbit sphincter of Oddi显示文摘AIM: The sphincter of Oddi (SO) plays an important role in delivery of bile into the duodenum. To establish whether vasoactive intestinal polypeptide (VIP) and nitric oxide (NO) were involved in phasic contractile activity of the rabbit SO stimulated by cholecystokinin-octapeptide (CCK-8).METHODS: Isolated SO muscle rings were cleaned of fat and mounted horizontally on two small L-shaped hooksone of which was connected to a force transducer for the measurement of isometric tension. The experiments were carried out in a thermostatically controlled (37±0.2℃)organ bath (5 mL) containing Krebs solution. The organ fluid was gassed with 95% O2 and 50 mL/L CO2 to keep the pH at 7.40±0.05. Contractile responses to CCK-8 (1μmol/L) were evaluated in the presence and absence of N^G-nitro-L-arginine (LNNA), an inhibitor of NO synthase (100μmol/L), and (p-chloro-D-Phe^6-Leu^17)-VIP (VIPa,30μmol/L), a VIP receptor antagonist.RESULTS: CCK-8 stimulated the phasic activity of the SO.NO synthase inhibition increased the frequency and amplitude of contractions with a slight increase in developed tension.Pre-incubation with VIPa also attenuated this CCK-8 effect.The combined application of LNNA and VIPa abolished the phasic activity of the muscle rings with a marked increase in tension in response to CCK-8.CONCLUSION: VIP and NO together contribute to an increase in phasic activity of SO. | Attila Pálv(o|¨)lgyi Réka Sári József Németh Annamária Szabolcs István Nagy Péter Hegyi János Lonovics Zoltán Szilvássy | 2005 | World Journal of Gastroenterology2005，11，21： | 11 |
| 2 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 3 | Gustatory perception alterations in obesity: An fMRI study显示文摘 | Csaba Szalay Mihály Aradi Attila Schwarcz Gergely Orsi Gábor Perlaki Lívia Németh Sophia Hanna Gábor Takács István Szabó László Bajnok András Vereczkei Tamás Dóczi József Janszky Sámuel Komoly Péter ?rs Horváth László Lénárd Zoltán Karadi | 2012 | Brain Research2012，，： | 1 |
| 4 | Isolation and characterization of three pairs of verrucosidin epimers from the marine sediment‑derived fungus Penicillium cyclopium and confguration revision of penicyrone A and related analogues显示文摘Verrucosidins,a methylatedα-pyrone class of polyketides rarely reported upon,have been implicated in one or more neurological diseases.Despite the signifcance of verrucosidins as neurotoxins,the absolute confgurations of most of the derivatives have not been accurately characterized yet.In this study,three pairs of C-9 epimeric verrucosidin derivatives,including the known compounds penicyrones A and B(1a/1b)and 9-O-methylpenicyrones A and B(2a/2b),the new compounds 9-O-ethylpenicyrones A and B(3a/3b),together with the related known derivative verrucosidin(4),were isolated and identifed from the culture extract of Penicillium cyclopium SD-413,which was obtained from the marine sediment collected from the East China sea.Their structures were established based on an in-depth analysis of nuclear magnetic resonances(NMR)and mass spectroscopic data.Determination of the absolute confgurations of these compounds was accomplished by Mosher’s method and time-dependent density functional theory(TDDFT)calculations of electronic circular dichroism(ECD)and optical rotation(OR).The confgurational assignment of penicyrone A demonstrated that the previously reported C-6 absolute confguration of verrucosidin derivatives needs to be revised from(6S)to(6R).The 9R/9S epimers of compounds 1–3 were found to exhibit growth inhibition against some pathogenic bacteria,indicating that they have potential as lead compounds for the creation of antimicrobial agents. | Yan-He Li Attila Mándi Hong-Lei Li Xiao-Ming Li Xin Li Ling-Hong Meng Sui-Qun Yang Xiao-Shan Shi Tibor Kurtán Bin-Gui Wang | 2023 | Marine Life Science & Technology2023，5，2： | 1 |
| 5 | CONSTITUTIVELY PHOTOMORPHOGENIC1 is required for the UV-B response in Arabidopsis显示文摘 | Attila O Alexander B Zoltán M Agnieszka B Jean M Edward J O (E)va (A) Eberhard S Ferenc N Roman U | | 0，，08： | 1 |
| 6 | Calpain-1-sensitive myofibrillar proteins of the human myocardium显示文摘 | Judit Barta Attila Tóth István édes Miklós Vaszily Julius Gy. Papp András Varró Zoltán Papp | 2005 | Molecular and Cellular Biochemistry (-)2005，，1： | 1 |
| 7 | Calpain-1-dependent degradation of troponin I mutants found in familial hypertrophic cardiomyopathy显示文摘 | Judit Barta Attila Tóth Kornelia Jaquet Alexander Redlich István édes Zoltán Papp | 2003 | Molecular and Cellular Biochemistry (-)2003，，1： | 1 |
| 8 | Anterior cham- ber depth measurements in phakic and pseudophakic eyes:Pen- tacam versus ultrasound device 显示文摘 | Gabor N Attila V Bence K Berta A Modis L Jr | 2006 | J Cataract Refract Surg2006，32，8： | 1 |
| 9 | Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrome P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients显示文摘 | Myriam Orellana Ramón Rodrigo Nelson Varela Julia Araya Jaime Poniachik Attila Csendes Gladys Smok Luis A. Videla | 2005 | Hepatology Research2005，，1： | 1 |
| 10 | Contribution of Distinct Structural Elements to Activation of Calpain by Ca2+Ions显示文摘 | Anita Alexa Zoltán Bozóky Attila Farkas | 2004 | J Biol Chem2004，279，20： | 1 |
| 11 | The influence of iron substitution to manganese on the physical properties of YMnO3 显示文摘 | Attila V Jacques N G Stephan F | 2006 | Solid State Sci2006，8，： | 1 |
| 12 | High Expression of Claudin-1 Protein in Papillary Thyroid Tumor and its Regional Lymph Node Metastasis显示文摘 | Júlia Németh Zsuzsanna Németh Péter Tátrai Ilona Péter áron Somorácz Attila Marcell Szász András Kiss Zsuzsa Schaff | 2010 | Pathology & Oncology Research2010，，1： | 1 |
| 13 | Anterior chamber depth measurements in phakic and pseddophakic eyes:Pentacam versus ultrasound device显示文摘 | Gabor N Attila V Bence K | 2006 | J Cataraci Refract Surg2006，32，13： | 1 |
| 14 | Anterior chamber depth measurements in phakic and pseudophakic eyes:Pentacam versus ultrasound device显示文摘 | Gabor N Attila V Bence K | 2006 | J Cataract Refract Surg2006，32，： | 1 |
| 15 | Opposite effects of lithium and valproic acid on trophic factor deprivation-induced glycogen synthase kinase-3 activation,c-Jun expression and neuronal cell death显示文摘 | Jin N Attila D Kovacs A D | 2005 | Neuropharmacology2005，48，4： | 1 |
| 16 | Voiding symptoms and Urodynamic findings in patients with modified ileal Neobladder 显示文摘 | ATTILA K ATTILA M PETER N | 2009 | Oncol Res2009，15，： | 1 |
| 17 | Yttrium Normalisation: a New Tool for Detection of Chromium Contamination in Soil Samples显示文摘 | József Prokisch Béla Kovács Attila J. Palencsár Ildikó Szegvári Zoltán Gy?ri | 2000 | Environmental Geochemistry and Health2000，，4： | 1 |
| 18 | Elevated levels of asymmetric dimethylarginine(ADMA) in the pericardial fluid of cardiac patientscorrelate with cardiac hypertrophy显示文摘 | ZOLTAN N ATTILA C SANDOR S | 2015 | Plos One2015，10，8： | 1 |
| 19 | Synthesis of Hy-perbranched Poly (ethyleneimine) Based Macromolecular Antioxidants and Investigation of Their Efficiency in Sta- bilization of Polyolefins显示文摘 | Kasza G Katarina M Attila N | 2015 | European Polymer Journal2015，68，： | 1 |
| 20 | Stimulation of endothelial nitric oxide production by homocyst(e)ine显示文摘 | Gilbert R Upchurch George N Welch Attila J Fabian Alessio Pigazzi John F Keaney Joseph Loscalzo | 1997 | Atherosclerosis1997，，2： | 1 |
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