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| 1 | Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers显示文摘Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ morphogenesis.Its impact on beef cattle muscle growth remains undefined.Method: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of age.At 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells.The resulting steers were harvested at 14 months of age.Results: Vitamin A administration increased cattle growth at 2 months.At 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and MYOG.Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro.More myotubes and a higher degree of myogenesis was observed in vitamin A groups.Consistently,vitamin A increased Latissimus dorsi(LD) muscle fiber size at harvest.In addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers.Furthermore,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal muscle.Conclusion: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers. | Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu Martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 2 | Breaking strength of dry fermented sausages and their correlation with texture profile analysis (TPA) and physico-chemical characteristics显示文摘 | Herrero A M Ord6fiez J A de Avila R | 2007 | Meat Science2007，77，3： | 1 |
| 3 | Variability of the international prostate symptom score in men with lower urinary tract symptoms显示文摘 | Connor R C Bales G T Avila D | 2003 | Scand J Urol Nephrol2003，37，： | 1 |
| 4 | Quantitation of gene expression in neural precursors by reverse-transcription polymerase chain reaction using self-quenched, fluorogenic primers显示文摘 | Lowe B Avila H A Bloom F R | 2003 | Anal Biochem2003，315，： | 1 |
| 5 | Signal peptideregulated toxicity of a plant ribosome-inactivating protein during cell stress显示文摘 | Marshall R S D′Avila F Di Cola A | | 0，，02： | 1 |
| 6 | PDGF-BBProtects Mitochondria from Rotenone in T98G Cells 显示文摘 | CABEZAS R FIDEL AVILA M GONZALEZ J | 2015 | Neurotoxicity Research2015，27，4： | 1 |
| 7 | Intraprocedural volume imaging of the left atrium and pulmonary veins with rotational X- ray angiography : implications for catheter ablation of atrial fibrillation 显示文摘 | Thiagalingam A Manzke R D'Avila A | 2008 | J Cardiovasc Electrophysiol2008，19，3： | 1 |
| 8 | 显示文摘 | V YOUNG R BECKERT W F | 1994 | Anal Chem1994，66，： | 1 |
| 9 | Atlantic tropical systems of 1991显示文摘 | AVILA L PASCH R J | 1992 | Mon Wea Rev1992，120，11： | 1 |
| 10 | Diagnostic and therapeutic urologic procedures显示文摘 | Stine R J Avila J A Lemons M F | | 0，，03： | 1 |
| 11 | Two genes encoding distinct cytosolic glutamine synthetanes are closely linked in the pine genome显示文摘 | Avila C Munoz-Chapuli R Plomion C | 2000 | FEBS Letters2000，477，： | 1 |
| 12 | Correlates of success in family business transitions显示文摘 | Morris M H Williams R O Allen J A and Avila R A | 1997 | Journal of Business Venturing1997，12，5： | 1 |
| 13 | Competitive sorption of cis-DCE and TCE in silica gel as a model porous mineral solid显示文摘 | AVILA M A S BREITER R | 2008 | Chemosphere2008，72，11： | 1 |
| 14 | Ammonium assimilation and amino acid metabolism in conifers显示文摘 | Cánovas F M Avila C Cantón F R Caňas R A Torre F | 2007 | Journal of Experimental Botany2007，58，9： | 1 |
| 15 | Individualism and the modern corporation -- Implications for innovation and entrepreneurship显示文摘 | Morris M H Avila R A and Allen J | 1993 | Journal of Management1993，19，3： | 1 |
| 16 | Maternal and fetal outcome in pregnant women with Eisenmenger's syndrome显示文摘 | Avila WS Grinberg M Snitcowsky R | 1995 | Eur Heart J1995，16，： | 1 |
| 17 | Glycogen synthase kinase 3 : a drug target for CNS therapies显示文摘 | Bhat R V Budd Haeberlein S L Avila J | 2004 | J Neurochem2004，89，6： | 1 |
| 18 | The leader proteinase of foot-and-mouth disease virus inhibits the induction of beta interferon mRNA and blocks the host innate immune response显示文摘 | de Los Santos T de Avila Botton S Weiblen R | 2006 | J Virol2006，80，4： | 1 |
| 19 | Maternal and fetal out-come in preg- nant women with Eisenmenger's syndrome显示文摘 | Avila WS Grinberg M Snitcowsky R | 1995 | Eur Heart J1995，16，4： | 1 |
| 20 | Assessment of cervical involvement in endometrial carcinoma by hysteroscopy and directed biopsy显示文摘 | Avila ML Ruiz R Cortaberria JR | 2008 | Int J Gynecol Cancer2008，18，： | 1 |
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