|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | Mature sacrococcygeal teratoma:a case report and literature review显示文摘 | Shonubi AM Musa AA Akiode O | 2004 | West Afr J Med2004，23，： | 1 |
| 3 | A QSAR analysis of toxicity of Aco- nitum alkaloids 显示文摘 | Bello-Ramirez AM Nava-Ocampo AA | 2004 | Fundam Clin Pharmaco12004，18，6： | 1 |
| 4 | The genotoxic and cytotoxic activities of inorganic fluoride in cultured rat bone marrow cells 显示文摘 | Khalil AM Da'dara AA | 1994 | Arch Environ Contam Toxicol1994，26，1： | 1 |
| 5 | In vivo Testing of a biostable Polyurethane显示文摘 | Szycher M Reed AM Siciliano AA | 1991 | J Biomater Appl1991，6，1： | 1 |
| 6 | Harmonic Scalpel compared with bipolar electro-cautery hemorrhoidectomy: a ran- domized controlled trial显示文摘 | Abo-hashem AA Sarhan A Aly AM | 2010 | Int J Surg2010，8，3： | 1 |
| 7 | Harmonic Scalpel compared with bipolar electro-cautery hemorrhoidectomy: a randomized con- trolled trlal显示文摘 | Abo-hashem AA Sarhan A Aly AM | 2010 | Int J Surg2010，8，3： | 1 |
| 8 | Anaesthetic maintenance with laryngeal mask for a laparoscopic surgery in pediatric patients 显示文摘 | Mironov PI Estekhin AM Mirasov AA | 2013 | Anesteziol Reanimatol2013，，1： | 1 |
| 9 | Targeted quantum dot conjugates for siRNA delivery显示文摘 | Derfus AM Chen AA Min DH | 2007 | Bioconjug Chem2007，18，5： | 1 |
| 10 | S-100 protein and neuron-specific enolase as markers of subclinical cerebral damage after cardiac surgery:preliminary observation of a 6-month follow-up study显示文摘 | Basile AM Fusi C Conti AA | 2001 | Eur Neurol2001，45，3： | 1 |
| 11 | Mature sacrococcygeal teratoma:a case report and literature reiew显示文摘 | Shonubi AM Musa AA Akiode O | 2004 | West Afr J Med2004，23，： | 1 |
| 12 | Endothelin-1 and nitric oxide levels in Patients with glaucoma 显示文摘 | Ghanem AA Elewa AM Arafa LF | 2011 | Ophthalmic-Res2011，46，2： | 1 |
| 13 | Colonic perforationduring percutaneous nephrolithotomy: study of risk factors显示文摘 | El-Nahas AR Shokeir AA El-Assmy AM | 2006 | Urology2006，67，5： | 1 |
| 14 | The complement system in systemic lupus erythematosus: an update显示文摘 | kefller J Bengtsson AA Blom AM | 2014 | Ann Rheum Dis2014，73，9： | 1 |
| 15 | Glucocorticoid receptor downregulation in early diagnosed rheumatoid arthritis显示文摘 | Huisman AM Van Everdingen AA Wenting MI | 2002 | Ann N Y Acad Sci2002，966，： | 1 |
| 16 | Use of octreotide for the prevention of pancreatic fistula after elective pancreatic surgery: a systematic review and meta-analysis 显示文摘 | Alghamdi AA Jawas AM Hart RS | 2007 | Can J Surg2007，50，6： | 1 |
| 17 | Risk factors associated with atrial fibrillation after noncardiae thoracic surgery:analysis of 2588 patients 显示文摘 | Vaporciyan AA Correa AM Rice DC | 2004 | J Thorac Cardiovasc Surg2004，127，3： | 1 |
| 18 | A novel nonclassic beta2-microglobulin-restricted mechanism influencing early lymphocyte accumulation and subsequent resistance to tuberculosis in the lung显示文摘 | Cooper AM Frank AA | 2000 | Am J Respir Cell Mol Biol2000，23，2： | 1 |
| 19 | A finite element study of a lumbar motion segment subjected to pure sagittal plane moments 显示文摘 | Shirazi AA Ahmed AM Shrivastava SC | 1986 | J Biomech1986，19，4： | 1 |
| 20 | Crystal structure of an integral membrane light-harvesting complex from photosynthetic bacteria 显示文摘 | McDermott G Prince SM Freer AA Hawthornthwaite-Lawless AM Papiz MZ Cogdell RJ Isaacs NW | 1995 | Articles1995，374，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员