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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Endoscopic Retrograde Cholangiopancreatography Gut Perforations: When to Wait! When to Operate!显示文摘 | Morgan Katherine A Fontenot Bennett B Ruddy Jean M Mickey Suzanne Adams David B | 2009 | The American Surgeon2009，，6： | 2 |
| 3 | Intravitreal triamcinolone for refractory diabetic macular edema显示文摘 | Adam Martidis Jay S Duker Paul B Greenberg Adam H Rogers Carmen A Puliafito Elias Reichel Caroline Baumal | 2002 | Ophthalmology2002，，5： | 2 |
| 4 | Performance of an adaptive multichannel combiner for long range underwater communications显示文摘 | Sharif B S Neasham J A Hinton O R Adams A E | 1996 | IEE Electronics letters1996，32，3： | 1 |
| 5 | Transient homodynamic effect of recruitment maneuvers in three experimental models of acute lung injury显示文摘 | Lin S C Adams A B Sinonson D A | 2004 | Crit Care Med2004，32，12： | 1 |
| 6 | A Computationally Efficient Doppler Compensation Sys tern for Under Water Acoustic Communications显示文摘 | Sharif B S Neasham J Hinton O R Adams A E | 2000 | IEEE Journal of Oceanic Engineering2000，25，1： | 1 |
| 7 | Astroglial activation of extracellular-regulated kinase in early stages of Alzheimer disease显示文摘 | Webster B Hansen L Adame A | 2006 | J Neuropathol Exp Neurol2006，65，： | 1 |
| 8 | A novel Pd/MgAlOx catalyst for NOX storage-reduction显示文摘 | SILLETTI B A ADAMS R T SIGMON S M NIKOLOPOULOS A SPIVEY J J LAMB H H | 2006 | Catal Today2006，114，1： | 1 |
| 9 | Effect of a chemical additive on Salmonella in poultry feed and host birds显示文摘 | WESTERFIELD B L ADAMS A W ERVIN L E | 1970 | Poult Sci1970，49，： | 1 |
| 10 | Viewpoint:experimental recovery of geometrically necessary dislocationdensity in polycrystals显示文摘 | EL-DASHER B S ADAMS B L ROLLETT A D | 2003 | Scripta Materialia2003，48，2： | 1 |
| 11 | Modeling the tryptic hydrolysis of pea proteins usingan artificial neural network显示文摘 | ADAM B MAGDALENA K RYSZARD A | | 0，，： | 1 |
| 12 | Diagnosis of perioperative myocardial infarction with measurement of cardiac troponin I显示文摘 | Sicard G A Allen B T | 1994 | N Engl J Med1994，330，： | 1 |
| 13 | Photoprotection and oth- er responses of plants to high light stress显示文摘 | Demmig A D Ams B Adams III w W | 1992 | Annual Review of Plant Physiology and Plant Molecular Biology1992，43，： | 1 |
| 14 | Proteasome inhibitor PS519 reduces infarction and at- tenuates leukocyte infiltration in a rat model of focal cerebral ischemia显示文摘 | PHILLIPS J B WILLIAMS A J ADAMS J | 2000 | Stroke2000，31，： | 1 |
| 15 | Characterisation and expression of a PP1serine/threonine protein phosphatase(PfPP1) from the malaria parasite, Plasmodiumfalciparum:demonstration of its essential role using RNA interference 显示文摘 | Kumar R Adams B Oldenburg A | 2002 | Malar J2002，1，1： | 1 |
| 16 | Differential development of progeni tor activityfor three B-cell lineages显示文摘 | Kantor A B ,Stall A M,Adams S | 1992 | Proc Natl Acad Sci USA,1992，，： | 1 |
| 17 | Hydrogen electrosorption into Pd-Cd nanostruetures显示文摘 | ADAMS B D OSTROM C K CHEN A C | 2010 | Langmuir2010，26，10： | 1 |
| 18 | Rapid changes in xanthophylls cycle-dependent energy dissipation and photosystem II efficiency in two vines, Stephania japonica and smilax austrilis, growing in the understroy of an open Eucalyptus forest显示文摘 | Adams WW III Demming-Adams B logan B A | 1999 | Plant Ceil Environ1999，，22： | 1 |
| 19 | Novel high capacitance materials:BaTiO3:La and CaCu3Ti4O12显示文摘 | West A R Adams T B Morrison F D | 2004 | J Euro Cera Soci2004，24，： | 1 |
| 20 | Odors in water of the Nile River 显示文摘 | Adams B A | 1929 | Water engineering1929，31，： | 1 |
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