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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | Adjuvant chemo- therapy use and adverse events among older patients with stage Ⅲ colon cancer显示文摘 | KAHN K L ADAMS J L WEEKS J C | 2010 | JAMA2010，303，11： | 1 |
| 3 | Evolution of duplicate gene expression in polyploid and hybrid plants 显示文摘 | Adams K L | 2007 | Journal of Heredity2007，98，： | 1 |
| 4 | Polyploidy and genome evolution inplants显示文摘 | Adams K L Wendel J F | 2005 | Curr Opin Plant Biol2005，，8： | 1 |
| 5 | Polyploidy and genome evolution in plants 显示文摘 | ADAMS K L WENDEL J F | 2005 | Curr Opin Plant Biol2005，8，2： | 1 |
| 6 | Polyploidy and genome evolution in plants显示文摘 | ADAMS K L WENDEL J F | 2005 | Current Opinion in Plant Bioloyg2005，8，： | 1 |
| 7 | Orientation imaging: the emergence of a new microscopy 显示文摘 | Adams B L Wright S I Kunze K | 1993 | Metall Trans1993，24，： | 1 |
| 8 | Nonalcoholic fatty liver disease 显示文摘 | ADAMS L A LINDOR K D | 2007 | Ann Epidemiol2007，17，11： | 1 |
| 9 | Professionalism beha- viors of hospital nurse executives and middle managers in 10 western states显示文摘 | Adams D Miller B K Beck L | 1996 | West J Nurs Res1996，18，1： | 1 |
| 10 | Comparative eco- toxicity of nanoscale TiO2, SiO, and ZnO water sus- pensions 显示文摘 | Adams L K Lyon D Y Alvarez P J | 2006 | Water Research2006，40，19： | 1 |
| 11 | Dendritic cell based PSMA immunotherapy for prostate cancer using a CD40-targeted adenovirus vector显示文摘 | Williams B J Bhatia S Adams L K | | 0，，10： | 1 |
| 12 | Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes 显示文摘 | Riechmann J L Heard J Martin G Reuber L Jiang C Keddie J Adam L Pineda O Ratcliffe O J Samaha R R Creelman R Pilgrim M Broun P Zhang J Z Ghandehari D Sherman B K Yu G | 2000 | Science2000，290，： | 1 |
| 13 | Osteoblastic cells regulate the haematopoietic stem cell niche 显示文摘 | CALVI L M ADAMS G B WEIBRECHT K W | 2003 | Nature2003，425，6960： | 1 |
| 14 | Organ-specific si- lencing of duplicated genes in a newly synthesized cotton allotetraploid 显示文摘 | Adams K L Percifield R Wendel J F | 2004 | Genetics2004，168，： | 1 |
| 15 | A simple sulfuric acid pretreatment method to improve the adsorption of Cr(Ⅵ)by chitosan显示文摘 | Lasko C L Adams K H Debenedet E M | | 0，，： | 1 |
| 16 | Estimating suspen-ded sediment concentration in surface waters of the Amazon Riv-er wetlands from Landsat images 显示文摘 | MERTRS L A K SMITH M 0 ADAMS J B | 1993 | Remote Sen Environ-ment1993，43，： | 1 |
| 17 | Osteoblastic cells regulate the haematopoietic stem cell niche显示文摘 | Calvi L M Adams G B Weibrecht K W | 2003 | Nature2003，425，6960： | 1 |
| 18 | Surface-generated mesoscale eddies transport deep-sea products from hydrothermal vents显示文摘 | Adams D K Mcgillicuddy D J Zamudio L | 2011 | Science2011，332，6029： | 1 |
| 19 | Physiological and psychological differences betweeen good and poor sleepers显示文摘 | Adam K Tomeny M Oswald L | 1986 | J Psychiatr Res1986，20，3： | 1 |
| 20 | Comparative eco- toxicity of nanoscale TiO2, SiO2 and ZnO water suspensions 显示文摘 | Adams L K Lyon D Y Alvarez P J J | 2006 | Water Research2006，40，19： | 1 |
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