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| 1 | Surgical treatment for liver cancer显示文摘Primary liver cancer is amongst the commonest tumors worldwide,particularly in parts of the developing world,and is increasing in incidence. Over the past three decades,surgical hepatic resection has evolved from a high risk,resource intensive procedure with limited application,to a safe and commonly performed operation with a range of indications. This article reviews the approach to surgical resection for malignancies such as hepatocellular cancer,metastatic liver de-posits and neuroendocrine tumors. Survival data after resection is also reviewed,as well as indications for curative resection. | Nicole C Tsim Adam E Frampton Nagy A Habib Long R Jiao | 2010 | World Journal of Gastroenterology2010，16，8： | 12 |
| 2 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 3 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 4 | 肝细胞肝癌和肝硬化组织中的卵圆细胞:电镜与免疫电镜研究显示文摘目的 从电镜和免疫电镜水平 ,探讨人类肝癌和肝硬化肝组织存在如动物肝癌形成实验中的卵圆细胞的可能性。方法 对 10例人肝细胞肝癌的手术标本及其癌旁肝硬化组织作了电镜超微结构观察 ,并用胆管上皮分化抗体CK7和肝细胞分化抗体白蛋白对以上组织作超薄切片免疫电镜标记。结果 电镜下 ,所有肝癌(10例 )和肝硬化 (10例 )组织均可找到与我们在人肝母细胞瘤、胆道闭锁肝中所见的三型小上皮细胞。这类细胞卵圆形 ,位于肝癌肿瘤边缘和增生的胆小管内 ,在肝硬化组织则位于汇管区及再生的肝结节内。免疫电镜下 ,三型卵圆细胞均表达CK7和白蛋白 ,但Ⅰ型和Ⅱ型表达CK7多些 ,Ⅲ型表达白蛋白多些。结论 人肝细胞肝癌和肝硬化肝组织中存在卵圆细胞 ,其形态和免疫表型特点与动物致癌模型肝中卵圆细胞一致。 | 肖家诚 金晓龙 曾晓颖 Ruck P Adam A Kaiserling E | 2004 | 检验医学2004，19，1： | 3 |
| 5 | Effect of varying computed tomography acquisition and reconstruction parameters on semi-automated clot volume quantification显示文摘AIM To examine effects of computed tomography(CT)image acquisition/reconstruction parameters on clot volume quantification in vitro for research method validation purposes.METHODS This study was performed in conformance with HIPAA and IRB Regulations(March 2015-November 2016).A ten blood clot phantom was designed and scanned on a dual-energy CT scanner(SOMATOM Force,Siemens Healthcare Gm BH,Erlangen,Germany)with varying pitch,iterative reconstruction,energy level and slicethickness.A range of clot and tube sizes were used in an attempt to replicate in vivo emboli found within central and segmental branches of the pulmonary arteries in patients with pulmonary emboli.Clot volume was the measured parameter and was analyzed by a single image analyst using a semi-automated region growing algorithm implemented in the FDA-approved Siemens syngo.via image analysis platform.Mixed model analysis was performed on the data.RESULTS On the acquisition side,the continuous factor of energy showed no statistically significant effect on absolute clot volume quantification(P=0.9898).On the other hand,when considering the fixed factor of pitch,there were statistically significant differences in clot volume quantification(P<0.0001).On the reconstruction side,with the continuous factor of reconstruction slice thickness no statistically significant effect on absolute clot volume quantification was demonstrated(P=0.4500).Also on the reconstruction side,with the fixed factor of using iterative reconstructions there was also no statistically significant effect on absolute clot volume quantification(P=0.3011).In addition,there was excellent R^2 correlation between the scale-measured mass of the clots both with respect to the CT measured volumes and with respect to volumes measure by the water displacement method.CONCLUSION Aside from varying pitch,changing CT acquisition parameters and using iterative reconstructions had no significant impact on clot volume quantification with a semi-automated region growing algorithm. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，3： | 3 |
| 6 | 肝硬化组织中卵圆细胞的光镜、电镜与免疫电镜观察显示文摘目的 :探讨人肝硬化肝组织是否存在卵圆细胞。方法 :对 30例人肝细胞肝癌手术标本的癌旁肝硬化组织行常规组织学观察 ,并用胆管上皮分化标记CK7和肝细胞分化标记白蛋白对以上组织作免疫组化染色 ,同时对其中 10例作了超微结构观察 ,5例作免疫电镜标记和观察。另外对 5例正常肝脏和 5例肝炎后肝硬化组织同时作了光镜、免疫组化和电镜观察 ,对 2例肝炎后肝硬化作了免疫电镜标记和观察。结果 :癌旁肝硬化组织的 30例光镜和 10例电镜观察以及 5例肝炎肝硬化光、电镜观察 ,均可在再生的肝细胞结节边缘见到散在的小细胞和增生的小胆管样结构。这些小细胞和增生的小胆管内少数小细胞 ,为卵圆形 ,体积较小 ,核大 ,胞质少 ,胞质内含较多的游离核糖体 ,仅含少量粗面内质网和线粒体 ,胞质内可见张力微丝结构 ,这类细胞与邻近细胞间均有细胞间连接。免疫电镜示 ,卵圆细胞均表达CK7和白蛋白 ,但有些细胞内表达CK7多些 ,有些细胞则表达白蛋白多些。在正常肝组织内未见到类似细胞。结论 :与动物实验性肝癌模型肝组织一样 ,人类肝硬化肝组织中也存在同样细胞形态和免疫表型特点的卵圆细胞。 | 肖家诚 王天翔 Ruck P Adam A Kaiserling E | 2002 | 临床与实验病理学杂志2002，18，1： | 3 |
| 7 | The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial显示文摘 | E Feldmann J L. Wilterdink A Kosinski M Lynn M I. Chimowitz J Sarafin H H. Smith F Nichols J Rogg H J. Cloft L Wechsler J Saver S R. Levine C Tegeler R Adams M Sloan | 2007 | Neurology2007，，24： | 2 |
| 8 | Impaired swallowing mechanics of post radiation therapy head and neck cancer patients: A retrospective videofluoroscopic study显示文摘AIM: To determine swallowing outcomes and hyolaryngeal mechanics associated with post radiation therapy head and neck cancer(rt HNC) patients using videofluoroscopic swallow studies. METHODS: In this retrospective cohort study, video-fluoroscopic images of rt HNC patients(n = 21) were compared with age and gender matched controls(n = 21). Penetration-aspiration of the bolus and bolus residue were measured as swallowing outcome variables. Timing and displacement measurements of the anterior and posterior muscular slings elevating the hyolaryngeal complex were acquired. Coordinate data of anatomical landmarks mapping the action of the anterior muscles(suprahyoid muscles) and posterior muscles(long pharyngeal muscles) were used to calculate the distance measurements, and slice numbers were used to calculate time intervals. Canonical variate analysis with post-hoc discriminant function analysis was performed on coordinate data to determine multivariate mechanics of swallowing associated with treatment. Pharyngeal constriction ratio(PCR) was also measured to determine if weak pharyngeal constriction is associated with post radiation therapy.RESULTS: The rt HNC group was characterized by poor swallowing outcomes compared to the control group in regards to: Penetration-aspiration scale(P < 0.0001), normalized residue ratio scale(NRRS) for the valleculae(P = 0.002) and NRRS for the piriform sinuses(P = 0.003). Timing and distance measurements of the anterior muscular sling were not significantly different in the two groups, whereas for the PMS time of displacement was abbreviated(P = 0.002) and distance of excursion was reduced(P = 0.02) in the rt HNC group. A canonical variate analysis shows a significant reduction in pharyngeal mechanics in the rt HNC group(P < 0.0001). The PCR was significantly higher in the test group than the control group(P = 0.0001) indicating reduced efficiency in pharyngeal clearance. CONCLUSION: Using videofluoroscopy, this study shows rt HNC patients have worse swallowing outcomes associated with reduced hyolaryngeal mechanics and pharyngeal constriction compared with controls. | William G Pearson Jr Alisa A Davidoff Zachary M Smith Dorothy E Adams Susan E Langmore | 2016 | World Journal of Radiology2016，8，2： | 2 |
| 9 | Blue-on-yellow perimetry can predict the development of glaucomatous visual field loss 显示文摘 | Johnson CA Adams A J Gasson E J | 1993 | ArchOphthalmol1993，111，： | 2 |
| 10 | Five-year survival following hepatic resection after neoadjuvant therapy for nonresectable colorectal显示文摘 | Adam R Avisar E Ariche A | | Annals of Surgical Oncology0，，： | 2 |
| 11 | 非酒精性脂肪性肝病和非酒精性脂肪性肝炎的无创性诊断显示文摘非酒精性脂肪性肝病(NAFLD)在美国和世界上许多其他地区都是最常见的慢性肝病,其患病率持续上升,目前美国约1/4的成人和10%的儿童患NAFLD。NAFLD包括多种疾病状态,从通常呈良性、非进展性临床过程的单纯性脂肪肝直至更为严重的、可进展为肝硬化和终末期肝病的非酒精性脂肪性肝炎(NASH)。目前,NASH的诊断依赖于创伤性肝活检,而肝活检存在取样和读片误差的缺陷。NASH的临床危险因素包括糖尿病和代谢综合征,但这些因素本身不足以预测NASH。常规肝酶水平预测可靠性低,新型血浆肝细胞死亡标记物单独或与临床危险因素联合今后可能成为无创性诊断工具。本文对无创性诊断工具在鉴别单纯性脂肪肝与NASH以及确定肝纤维化的存在及其范围中的作用作一概述。 | Leon A ADAMS Ariel E FELDSTEIN 张海燕 钱本余 马雄 | 2011 | 胃肠病学2011，16，3： | 2 |
| 12 | Performance of an adaptive multichannel combiner for long range underwater communications显示文摘 | Sharif B S Neasham J A Hinton O R Adams A E | 1996 | IEE Electronics letters1996，32，3： | 1 |
| 13 | A Computationally Efficient Doppler Compensation Sys tern for Under Water Acoustic Communications显示文摘 | Sharif B S Neasham J Hinton O R Adams A E | 2000 | IEEE Journal of Oceanic Engineering2000，25，1： | 1 |
| 14 | Diffuse axonal in- jury and traumatic coma in the primate 显示文摘 | Gennarelli T A Thibault L E Adams J H | 1982 | Ann Neurol1982，12，6： | 1 |
| 15 | Large-eddy simulation of starting buoyant jets显示文摘 | Wang R Q Law A W K Adams E E | 2011 | Environmental Fluid Mechanics2011，11，6： | 1 |
| 16 | Model estimates of CO2 emissions from soil in response to global warming显示文摘 | Jenkinson D S Adams D E Wild A | 1991 | Nature1991，351，： | 1 |
| 17 | Diffusion -weignted MR Imaging for differentiation of benign fracture edema and tumor infiltration of the vertebral body显示文摘 | Spuentrup E Buecker A Adam G | 2001 | AJR2001，176，2： | 1 |
| 18 | Effect of a chemical additive on Salmonella in poultry feed and host birds显示文摘 | WESTERFIELD B L ADAMS A W ERVIN L E | 1970 | Poult Sci1970，49，： | 1 |
| 19 | The concordance of tetraploid, ISSR and RAPD markers, and ITS sequence data sets among genotypes: an example from Juniperus显示文摘 | ADAMS R P SCHWARZBACH A E PANDEY R N | 2003 | Biochem Systematics and Ecol2003，31，： | 1 |
| 20 | A social networkcaught in the Web显示文摘 | ADAMIC L A BUYUKKOKTEN O ADAR E | 2003 | First Monday2003，6，8： | 1 |
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