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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Tumor necrosis factor stimulates amylin secretion but inhibits insulin from islet β-cells by independent pathways显示文摘 | Ding X Z Flatt P R Adrian T E | 1996 | Regulatory Peptides1996，64，3： | 1 |
| 3 | On the relationships between local vortex identification schemes显示文摘 | Chakraborty P Balachandar S Adrian R J | 2005 | Journal of Fluid Mechanics2005，535，1： | 1 |
| 4 | HPLC analysis of grapevine phytoalexins coupling photodiode array detection and fluorometry显示文摘 | JEANDET P BREUIL A C ADRIAN M WESTON L A DEBORD S MEUNIER P MAUME G BESSIS R | 1997 | Analytical Chemistry1997，69，24： | 1 |
| 5 | Dynamic and design criteria of inertia type tree shaker 显示文摘 | Adrian P A Fridley R B | 1965 | Transactions of the ASAE1965，8，1： | 1 |
| 6 | Dynamics and design criteria of inertia type tree shakers显示文摘 | Adrian P A Fridley R B | 1965 | Transactions of the ASAE1965，8，1： | 1 |
| 7 | Comparison of magnetic parameters of urban atmospheric particulate matter with pollution and meteorologicaldata显示文摘 | Adrian R M Jtirgen M Nikolai P | 2001 | Atmospheric Environment2001，35，26： | 1 |
| 8 | Early development and quorum sensing in bacterial biofilms显示文摘 | John P Ward John R King Adrian J Koerber | 2003 | J Math Biology2003，47，1： | 1 |
| 9 | On the relationships between local vortex identification schemes显示文摘 | Chakraborty P Balachandar S Adrian R J | 2005 | J Fluid Mech2005，535，： | 1 |
| 10 | A conceptual evaluation of the multiple dimensions of relationship marketing显示文摘 | ADRIAN P MAYER J R | 1996 | Journal of Strategic Marketing1996，4，4： | 1 |
| 11 | Theory of crass-correlation of PIV images 显示文摘 | KEANE R P ADRIAN R J | 1992 | Applied Sci Res1992，49，： | 1 |
| 12 | On-table reconstruction of comminuted fractures of the radial head 显示文摘 | Adrian B Thomas P R Christoph S | 2010 | Injury2010，41，6： | 1 |
| 13 | Phytoalexins from the Vitaceae:biosynthesis,phytoalexin gene expression in transgenic plants,antifungal activity and metabolism显示文摘 | JEANDET P DOUILLET-BREUIL A C BESSIS R DEBORD S SBAGHI M ADRIAN M | 2002 | J Agric Food Chem2002，50，： | 1 |
| 14 | A method for spark rejection in ultraviolet flame detectors显示文摘 | Pauchard R P Manic D Adrian F | 2000 | IEEE Transactions on Industrial Electronics2000，47，1： | 1 |
| 15 | Does allowing the sale of winein Quebec grocery stores increase consumption显示文摘 | ADRIAN M JEANDET P BESSIS R | 1996 | Agric Food Chem1996，44，： | 1 |
| 16 | Shivering, muscle tone, and uncoupling proteins in a developing marsupial, the Tasmanian bettong (Bettongia gaimardi) 显示文摘 | Alexander P K Randy W R Adrian K W | 2007 | J Thermal Biol2007，32，： | 1 |
| 17 | Plant regeneration from seedling explants of Eucalyptus grandis of Europhylla 显示文摘 | Luis P B C Adriane C M G Silvia B R C | 1999 | Plant Cell Tissue and Organ Culture1999，56，： | 1 |
| 18 | Fluorous phase chemistry:a new industrial technology显示文摘 | Meriel R K | 2002 | Journal of Fluorine Chemistry2002，118，12： | 1 |
| 19 | Dynamics and design criteria of inertia type tree shakers 显示文摘 | Adrian P A Fridley R B | 1965 | Transactions of the ASAE1965，8，1： | 1 |
| 20 | Flavonoid profiles of New Zealand Libocedrus and related genera 显示文摘 | Kenneth R M Adrian F Brian P J M | 1990 | Phytochemistry1990，29，2： | 1 |
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