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| 1 | Atorvastatin and rosuvastatin do not prevent thioacetamide induced liver cirrhosis in rats显示文摘AIM:To examine whether the administration of atorvastatin and rosuvastatin would prevent experimentallyinduced hepatic cirrhosis in rats.METHODS:Liver cirrhosis was induced by injections of thioacetamide(TAA).Rats were treated concurrently with TAA alone or TAA and either atorvastatin(1,10 and 20 mg/kg) or rosuvastatin(1,2.5,5,10 and 20 mg/kg) given daily by nasogastric gavage.RESULTS:Liver fibrosis and hepatic hydroxyproline content,in the TAA-treated group was significantly higher than those of the controls [11.5 ± 3.2 vs 2.6 ± 0.6 mg/g protein(P = 0.02)].There were no differences in serum aminotransferase levels in the TAA controls compared to all the groups treated concomitantly by statins.Both statins used in our study did not prevent liver fibrosis or reduce portal hypertension,and had no effect on hepatic oxidative stress.Accordingly,the hepatic level of malondialdehyde was not lower in those groups treated by TAA + statins compared to TAA only.In vitro studies,using the BrdU method have shown that atorvastatin had no effect of hepatic stellate cells proliferation.Nevertheless,statin treatment was not associated with worsening of liver damage,portal hypertension or survival rate.CONCLUSION:Atorvastatin or rosuvastatin did not inhibit TAA-induced liver cirrhosis or oxidative stress in rats.Whether statins may have therapeutic applications in hepatic fibrosis due to other etiologies deserve further investigation. | Haim Shirin Efrat Sharvit Hussein Aeed Dov Gavish Rafael Bruck | 2013 | World Journal of Gastroenterology2013，19，2： | 2 |
| 2 | Pyrrolidine dithiocarbamate protects against thioacetamide - induced fulminant hepatic failure in rats 显示文摘 | Bruck R Aeed H Schey R | 2002 | J Hepatol2002，36，3： | 1 |
| 3 | Inhibition of immune-mediated concanavalin a-induced liver damage by free-radical scavengers显示文摘 | Shirin H Aeed H Alin A | 2010 | Dig Dis Sci2010，55，2： | 1 |
| 4 | Melatonin inhibits nuclear factor kappa B activation and oxidative stress and protects against thioacetamide induced liver damage in rats显示文摘 | BRUCK R AEED H AVNI Y | 2004 | J Hepatol2004，40，1： | 1 |
| 5 | Glycosylation of recombinant protein in insect cells:the insect cell line Sf9 does not express the mannose 6-phosphate recognition signal显示文摘 | Elhammer A P | 1994 | Biochemistry1994，33，： | 1 |
| 6 | A protective effect of pyrrolidine dithiocarbamate in a rat model of liver cirrhosis显示文摘 | Bruck R Schey R Aeed H | 2004 | Liver Int2004，24，2： | 1 |
| 7 | Aprotective effect of pyrrolidine diduocar bamate in a fat model of Liver cirrhosis显示文摘 | Bruck R Schey R Aeed H | 2004 | Liver Int2004，24，2： | 1 |
| 8 | 显示文摘 | Bruck R Genina O Aeed H | 2001 | Hepatology2001，33，2： | 1 |
| 9 | Apmteetiv eeffeet of pyrmlidine dithioear bamate in a fat model of liver eirrhosis 显示文摘 | Bruek R Sehey R Aeed H | 2004 | Liver Int2004，24，2： | 1 |
| 10 | The use of synthetic analogues of Arg - Gly - Asp (RGD) and soluble receptor of tumor necrosis factor to prevent acute and chronic experimental liver injury显示文摘 | Bruck R Hershkoviz R Lider O Shirin H Aeed H Halpern Z | 1997 | Yale J Biol Med1997，70，4： | 1 |
| 11 | Prevention of hepatic cirrhosis in rats by hydroxyl radical scavengers显示文摘 | Bruck R Shirin H Aeed H | 2001 | J Hepatol2001，35，4： | 1 |
| 12 | Treatment of thioacetamide-indueed liver cirrhosis by the Ras antagonist, farnesylthiosalicylic acid显示文摘 | REIF S AEED H SHILO Y | 2004 | J Hepatol2004，41，2： | 1 |
| 13 | Treatment of coneanavalin A-induced hepatitis in mice with low molecular weight heparin显示文摘 | Hershkoviz R Bruck R Aeed H | 1999 | J Hepatology1999，31，5： | 1 |
| 14 | Thioacetamide-induced hepatic damage in a rat nutritional model of steatohepatitis显示文摘 | Avni Y Shirin H Aeed H | 2004 | Hepatai Res2004，30，3： | 1 |
| 15 | Influence of different B-complex recombinants on the outcome of Rous sarcomas in chickens显示文摘 | Aeed P A Briles W E Zsigray R M | 1993 | Animal Genetics1993，24，： | 1 |
| 16 | Aprotective effct of pyrrolidine dithiocar bamate in a fat model of Liver cirrhosis 显示文摘 | Bruck R Aeed H | 2004 | Liver hat2004，24，2： | 1 |
| 17 | Prevention of hepatic cirrhosis in rats by hydroxyl radical scavengers显示文摘 | Bruck R Shirin H Aeed H | 2001 | J Hepatology2001，，5： | 1 |
| 18 | Prevention of hepatic cirrhosis in rats by by hydroxyl radical scavengers显示文摘 | Brock R Shirin H Aeed H | 2001 | J Hepatology2001，35，5： | 1 |
| 19 | Treatment of concanavalin A -induced hepatitis in mice with low molecular weight heparin显示文摘 | Hershkoviz R Bruck R Aeed H | 1999 | J Hepatol1999，31，5： | 1 |
| 20 | Prevention of hepatic cirrhosis in rats by hydroxyl radical scavengers显示文摘 | Bruck R Shirin H Aeed H | 2001 | J Hepatol2001，35，4： | 1 |
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