|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Crop photosynthetic response to light quality and light intensity显示文摘Under natural conditions, plants constantly encounter various biotic and abiotic factors, which can potentially restrict plant growth and development and even limit crop productivity. Among various abiotic factors affecting plant photosynthesis, light serves as an important factor that drives carbon metabolism in plants and supports life on earth. The two components of light(light quality and light intensity) greatly affect plant photosynthesis and other plant's morphological, physiological and biochemical parameters. The response of plants to different spectral radiations and intensities differs in various species and also depends on growing conditions. To date, much research has been conducted regarding how different spectral radiations of varying intensity can affect plant growth and development. This review is an effort to briefly summarize the available information on the effects of light components on various plant parameters such as stem and leaf morphology and anatomy, stomatal development, photosynthetic apparatus, pigment composition, reactive oxygen species(ROS) production, antioxidants, and hormone production. | Iram SHAFIQ Sajad HUSSAIN Muhammad Ali RAZA Nasir IQBAL Muhammad Ahsan ASGHAR Ali RAZA FAN Yuan-fang Maryam MUMTAZ Muhammad SHOAIB Muhammad ANSAR Abdul MANAF YANG Wen-yu YANG Feng | 2021 | Journal of Integrative Agriculture2021，20，1： | 16 |
| 2 | Negative reflection and negative surface wave conversion from obliquely incident electromagnetic waves显示文摘Complete control of spatially propagating waves(PWs)and surface waves(SWs)is an ultimate goal that scientists and engineers seek for,in which negative reflection of PW and negative surface wave are two exotic phenomena.Here,we experimentally demonstrate an anisotropic digital coding metasurface capable of controlling both PWs and SWs with a single coding pattern.On the basis of the digital description of coding metasurfaces,a simple coding method is proposed to allow dual functionalities(either PW or SW manipulations)under two orthogonal polarizations at arbitrarily oblique incidences,thus improving the adaptability of digital coding metasurfaces in more practical circumstances.With elaborately designed ellipse-shaped coding particles,we experimentally demonstrate various functions under oblique incidences,including the negative reflection of PW,negative SW,anomalous reflection and their arbitrary combinations,all having good agreements with theoretical and numerical predictions.We believe that the proposed method may enable the digital coding metasurfaces to have broad applications in radar detections,wireless communications and imaging. | Shuo Liu Tie Jun Cui Ahsan Noor Zui Tao Hao Chi Zhang Guo Dong Bai Yan Yang Xiao Yang Zhou | 2018 | Light(Science & Applications)2018，7，1： | 10 |
| 3 | Airship aerodynamic model estimation using unscented Kalman filter显示文摘An airship model is made-up of aerostatic,aerodynamic,dynamic,and propulsive forces and torques.Besides others,the computation of aerodynamic forces and torques is difficult.Usually,wind tunnel experimentation and potential flow theory are used for their calculations.However,the limitations of these methods pose difficulties in their accurate calculation.In this work,an online estimation scheme based on unscented Kalman filter(UKF)is proposed for their calculation.The proposed method introduces six auxiliary states for the complete aerodynamic model.UKF uses an extended model and provides an estimate of a complete state vector along with auxiliary states.The proposed method uses the minimum auxiliary state variables for the approximation of the complete aerodynamic model that makes it computationally less intensive.UKF estimation performance is evaluated by developing a nonlinear simulation environment for University of Engineering and Technology,Taxila(UETT)airship.Estimator performance is vali��dated by performing the error analysis based on estimation error and 2-σ uncertainty bound.For the same problem,the extended Kalman filter(EKF)is also implemented and its results are compared with UKF.The simulation results show that UKF successfully estimates the forces and torques due to the aerodynamic model with small estimation error and the comparative analysis with EKF shows that UKF improves the estimation re��sults and also it is more suitable for the under-consideration problem. | WASIM Muhammad ALI Ahsan | 2020 | Journal of Systems Engineering and Electronics2020，31，6： | 9 |
| 4 | Plant-derived anticancer agents: A green anticancer approach显示文摘Cancer is a frightful disease and represents one of the biggest health-care issues for the human race and demands a proactive strategy for cure. Plants are reservoirs for novel chemical entities and provide a promising line for research on cancer. Hitherto, being effective, chemotherapy is accompanied by certain unbearable side effects. Nevertheless,plants and plant derived products is a revolutionizing field as these are Simple, safer, ecofriendly, low-cost, fast, and less toxic as compared with conventional treatment methods.Phytochemicals are selective in their functions and acts specifically on tumor cells without affecting normal cells. Carcinogenesis is complex phenomena that involves many signaling cascades. Phytochemicals are considered suitable candidates for anticancer drug development due to their pleiotropic actions on target events with multiple manners. The research is in progress for developing potential candidates(those can block or slow down the growth of cancer cells without any side effects) from these phytochemicals. Many phytochemicals and their derived analogs have been identified as potential candidates for anticancer therapy. Effort has been made through this comprehensive review to highlight the recent developments and milestones achieved in cancer therapies using phytomolecules with their mechanism of action on nuclear and cellular factors. Furthermore, drugs for cancer treatment and their limitations have also been discussed. | Javed Iqbal Banzeer Ahsan Abbasi Tariq Mahmood Sobia Kanwal Barkat Ali Sayed Afzal Shah Ali Talha Khalil | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，12： | 8 |
| 5 | 极端嗜热菌海栖热袍菌木聚糖酶B的克隆和表达显示文摘极端嗜热菌海栖热袍菌MSB8(ThermotogamaritimaMSB8)能够利用木聚糖代谢 ,并具有两个产木聚糖酶的基因 .本研究首次克隆和在大肠杆菌中表达海栖热袍菌MSB8的第 2个木聚糖酶基因即xynB基因 .以基因组DNA为模板 ,根据xynB基因的全序列设计了两对引物 ,在合适的PCR反应条件下有效地扩增出了xynB基因片段 .选用pET2 8a(+)表达载体 ,NcoI-HindⅢ酶切位点并编码了羧基端 6×His标签的阳性克隆表达成可溶且具有生物活性的蛋白质 .xynB结构基因由 10 4 4对碱基组成 ,编码 347个氨基酸 .根据已知木聚糖酶蛋白质氨基酸的同源性分析 ,XynB与T .sp.strainFjSS3-B .1的XynA的同源性最大 ,为 85 % ,与T .neapolitana的XynB同源性次之 ,为 82 % ,与其它木聚糖酶的同源性小于 4 3% .另外 ,XynB属于F/ 10族木聚糖酶 ,且含有单一功能区 .表 3图 3参 | 江正强 李里特 林清 MOHAMMAD Mainul Ahsan | 2002 | 应用与环境生物学报2002，8，3： | 8 |
| 6 | 海栖热袍菌极端耐热木聚糖酶B的提纯显示文摘克隆并在大肠杆菌中表达的海栖热袍菌的 xyn B基因 ,其表达产物木聚糖酶 B的 C 末端带有 6×His标签 ,研究了这种基因重组酶的提纯方法。通过对粗酶提取液的热变性处理 ,Ni NTA亲和柱层析和离子柱层析 ,最终得到了电泳纯的木聚糖酶 B,提纯倍数 4 4.4 ,得率 11。SDS PAGE法测定木聚糖酶 B的相对分子质量为 4 2 ku,与理论推算值 4 2 | 江正强 李里特 林清 Mohammad Mainul Ahsan | 2001 | 中国农业大学学报2001，6，6： | 8 |
| 7 | Comparative assessment of total polyphenols, antioxidant and antimicrobial activity of different tea varieties of Bangladesh显示文摘Objective: To determine the total polyphenol content, antioxidant activity and antibacterial properties of the extracts of different Bangladeshi tea varieties such as flowery broken orange pekoe, broken orange pekoe, red dust and green tea.Methods: Total phenolic and flavonoid contents were determined by Folin–Ciocalteu and aluminum chloride colorimetric assay, respectively.The antioxidant capacity was determined by ferric ion reducing antioxidant power and phosphomolybdenum method.Antibacterial activity was evaluated by disc diffusion method in agar plate and subsequently, the minimum inhibitory concentration was determined by broth dilution method.Results: Total phenolic and flavonoid contents were significantly higher(P < 0.05) in green tea compared to other three black tea varieties.The green tea also showed a higher free radical scavenging and antioxidant activities than all the other tea varieties tested(P < 0.05).In addition, the extracts of all four tea varieties showed inhibitory activity against several pathogenic bacteria and also the same trend of higher antimicrobial activity of green tea than other tea varieties was observed.Conclusions: Taken together, the results of this study demonstrated that Bangladeshi tea,especially the green tea, may act as a substitute for natural antioxidants and as a promising antibacterial agent for beneficial influence in human health. | Yead Morshed Nibir Ahmed Faisal Sumit Anwarul Azim Akhand Nazmul Ahsan Mohammad Shahnoor Hossain | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，4： | 6 |
| 8 | Big Data Analytics in Telecommunications: Literature Review and Architecture Recommendations显示文摘This paper focuses on facilitating state-of-the-art applications of big data analytics(BDA) architectures and infrastructures to telecommunications(telecom) industrial sector.Telecom companies are dealing with terabytes to petabytes of data on a daily basis. Io T applications in telecom are further contributing to this data deluge. Recent advances in BDA have exposed new opportunities to get actionable insights from telecom big data. These benefits and the fast-changing BDA technology landscape make it important to investigate existing BDA applications to telecom sector. For this, we initially determine published research on BDA applications to telecom through a systematic literature review through which we filter 38 articles and categorize them in frameworks, use cases, literature reviews, white papers and experimental validations. We also discuss the benefits and challenges mentioned in these articles. We find that experiments are all proof of concepts(POC) on a severely limited BDA technology stack(as compared to the available technology stack), i.e.,we did not find any work focusing on full-fledged BDA implementation in an operational telecom environment. To facilitate these applications at research-level, we propose a state-of-the-art lambda architecture for BDA pipeline implementation(called Lambda Tel) based completely on open source BDA technologies and the standard Python language, along with relevant guidelines.We discovered only one research paper which presented a relatively-limited lambda architecture using the proprietary AWS cloud infrastructure. We believe Lambda Tel presents a clear roadmap for telecom industry practitioners to implement and enhance BDA applications in their enterprises. | Hira Zahid Tariq Mahmood Ahsan Morshed Timos Sellis | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，1： | 6 |
| 9 | 基于单摄像机空位检测技术的全天停车需求分析显示文摘为了给交通管理和决策制定提供依据,已有很多针对停车需求的研究,其中对停车场实际数据的统计分析尤为重要.本研究借助单摄像机空位检测系统,获取了位于阿布扎比市区的通用路外停车场全天的停车状况.具体检测方法为,根据停车位的视觉特征并利用图像识别来定义车位的占用或空闲状态.本文的空位检测系统具备两个突出优点:首先,和其他方法相比,它需要的像素点更少,单个摄像机能覆盖超过150个停车位;其次,无论白天还是夜间,系统的工作性能受光照条件的影响很小.实验结果表明,在研究时段内,占用车位的检测精度为99.9%,空闲车位的检测精度为97.9%.此外,当停车场接近饱和时,由于利用率不能包含没有获得停车位的驾驶员的停车需求,本文基于此问题提出了一种更加准确的描述方法. | JERMSURAWONG Jermsak AHSAN Umair HAIDAR Abdulhamid DONG Haiwei MAVRIDIS Nikolaos | 2014 | 交通运输系统工程与信息2014，14，2： | 6 |
| 10 | 抗菌剂效果和 Zataria multiflora Boiss 的香精油的物理化学的性质显示文摘 <正>Objective:To evaluate the antibacterial effect and physicochemical properties of essential oil of Zataria multiflora Boiss.Methods:Antibacterial activity of essential oil of Zataria multiflora Boiss was assessed by agar disc diffusion and minimal inhibitory concentration(MIC) was tested by E test.Results:The essential oil of Zataria multiflora Boiss was effective on pathogenic bacteria particularly Staphylococcus aureus(S.aureus).The MIC values of the target cultures ranged from 0.39 mg/mL to 1.56 mg/mL.The physicochemical properties like effects of pH, temperature,detergents,and enzymes on the activity of essential oil from Zataria multiflora Boiss were also determined.The essential oil was quite stable to temperature as tested against 5. aureus and Escherichia coli(E.coli).The essential oil was very stable over a wide range of pH. The antibacterial activity of essential oil was insensitive to various protein-denaturing detergents (Such as Tween 80,Tween 20,Triton 100,etc.) and enzymes(namely proteinase K,trypsin, lipase,and lysosyme).Conclusions:A potential use of the essential oil from Zataria multiflora Boiss is suggested.More studies including further purification,mass spectra,nuclear magnetic resonance(NMR) and evaluation of toxicity are needed for confirmation of this suggestion. | Mansour Amin Enayat Kalantar Neda Mohammad-Saeid Behzad Ahsan | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，6： | 5 |
| 11 | Improved mechanical proprieties of“magnesium based composites”with titaniume-aluminum hybrids显示文摘In this study,the effect of micron-sized titanium and aluminum addition on the microstructural,mechanical and work-hardening behavior of pure Mg is investigated.Pure Mg reinforced with 10%Ti and 10%Ti-1%Al particulates were synthesized through semi-powder metallurgy route followed by hot extrusion.Semi-powder metallurgy appears to be promising approach for the synthesis of Mg based composite,as it is free of ball milling.Tensile results indicate that the direct addition of micron-sized 10wt.%titanium particulates to pure Mg,caused an improvement in elastic modulus,0.2%yield strength,ultimate tensile strength,and failure strain(+72%;+41%;+29%;and+79%respectively).The addition of micron-sized 10wt.%titanium particles along with 1.0wt.%Al particles to pure Mg,resulted in an enhancement in elastic modulus,0.2%yield strength,ultimate tensile strength,and failure strain(+74%;+56%;+45%;and+241%respectively).Besides tensile test,Vickers hardness and work-hardening behavior of prepared composites were also examined.Impressive failure strain of Mg-10Ti-1Al composite can be attributed to the better compatibility of Ti particulates with Mg due to presence of alloying element Al. | Muhammad Rashad Fusheng Pan Muhammad Asif Jia She Ahsan Ullah | 2015 | Journal of Magnesium and Alloys2015，3，1： | 4 |
| 12 | Melatonin receptor agonist ramelteon attenuates mouse acute and chronic ischemic brain injury显示文摘Melatonin receptors(MTs)are potential drug targets for stroke therapy.Ramelteon is a selective melatonin receptor agonist used to treat insomnia.In this study we investigated whether ramelteon could attenuate cerebral ischemia in mice.Acute focal cerebral ischemia was induced in mice via middle cerebral artery occlusion(MCAO).We found oral administration of ramelteon(3.0 mg/kg)significantly attenuated ischemic injury even when it was given 4 h after the onset of ischemia.We showed that administration of ramelteon(3.0 mg/kg)displayed comparable protective efficacy and length of effective time window as administration of edaravone(10 mg/kg,ip.),which was used in dlinic to treat ischemic stroke.Chronic ischemic brain injury was induced in mice using photothrombosis.Oral administration of ramelteon(3.0 mg·kg^-1·d^-1)for 7 days after ischemia significantly attenuated functional deficits for at least 15 days.The neuroprotection of ramelteon was blocked by 4-P-PDOT,a specific MT antagonist.We further revealed that ramelteon significantly inhibited autophagy in the per-infarct cortex in both the mouse ischemia models via regulating AMPK/mTOR signaling pathway.Intracerebroventricular injection of rapamycin,an autophagy actiator,compromised the neuroprotection of ramelteon,suggesting ramelteon might attenuate ischemic injury by counteracting autophagic cell death.These data demonstrate for the first time the potential benefts of ramelteon in the treatment of both acute and chronic ischemic brain injury and provide the rationale for the application of ramelteon in stroke therapy. | Xiao-li Wu Shou-sheng Lu Meng-ru Liu Wei-dong Tang Jun-zi Chen Yan-rong Zheng Anil Ahsan Ming Cao Lei Jiang Wei-wei Hu Jia-ying Wu Zhong Chen Xiang-nan Zhang | 2020 | Acta Pharmacologica Sinica2020，41，8： | 4 |
| 13 | Analysis of immune responses against H pylori in rabbits显示文摘AIM: To investigate the immunogenicity of H pylori proteins, to evaluate the production rate of anti H pylori IgG antibodies in relation to time and to demonstrate the fidelity of newly optimized in-house enzyme- linked immunosorbent assay (ELISA) technique as an alternative for H pylori infection assay. METHODS: In the present study, 100 μg of formalin- fixed H pylori whole cell antigens was injected into an experimental animal (New Zealand white female rabbit) intramuscularly on d 0, 16, 27 and 36. The first two doses were injected with adjuvants. On d 0, a serum sample was collected from the rabbit before immunization and this pre-immunized serum was used as a negative control for the whole study. To evaluate the immunogenic responses of the injected antigen, serum samples were collected from the rabbit at regular intervals up to d 42. The sera were analyzed using in- house ELISA and Western blot techniques. RESULTS: The production of anti H pylori IgG antibodies in the rabbit in response to the injected antigen increased almost exponentially up to d 14 and after that it was maintained at the same level until the last day (d 42). By analyzing the immune profiles of immunized sera, 11 proteins were identified to be immunogenic, among them 2 (approximately 100 kDa and 85 kDa) were most prominent. CONCLUSION: Analysis of the immune responses against pathogenic microorganisms like H pylori is necessary for the development of various diagnostic and preventive approaches. The results of this experiment reveal that the formalin-fixed H pylori whole cell antigens injected into the rabbit are highly immunogenic. These prominent proteins (approximately 100 kDa and 85 kDa) might have higher immunogenic effects among humansinfected with H pylori and some of these immunogenic proteins can be included in diagnostic approaches based on serology and also for vaccine formulation. The in- house ELISA is a promising alternative compared to invasive techniques. | Khademul Islam Ibrahim Khalil Chowdhury Rafiqul Ahsan Mahmuda Yasmin Jamalun Nessa | 2007 | World Journal of Gastroenterology2007，13，4： | 4 |
| 14 | Acupuncture/Electroacupuncture as an Alternative in Current Opioid Crisis显示文摘Opioid drugs are the first line of defense in severe pain but the adverse effects associated with opioids are considered as a serious issue worldwide.Acupuncture/electroacupuncture is a type of Chinese medicine therapy which is an effective analgesic therapy,well documented in animals and human studies.Electroacupuncture stimulation could release endogenous opioid peptides causing analgesia in a variety of pain models.It can be used as an alternative therapy to control the opioid crisis. | Usman Ali Evhy Apryani Muhammad Zaeem Ahsan Rana Muhammad Shoaib Khalil AN Ahmad WANG Yong-xiang | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 4 |
| 15 | 我国跨境电商企业社会责任主动前移战略研究显示文摘我国跨境电商企业仍处于发展初期,由于传统监督体系的不适用,其社会责任行为同其他行业相比更加不规范,呈现明显的被动回应特征,导致跨境走私、商品假冒、偷税漏税、维权困难等责任问题层出不穷,严重制约了我国跨境贸易健康长远发展。因此,亟须探索适用于我国跨境电商企业长远发展的社会责任行为方式,针对不同规模的企业制定不同的社会责任行为战略以及具体的实施方案,以提高我国跨境电商企业的国际竞争力,加快可持续竞争优势的形成,为我国跨境电商企业的新一轮创新与发展奠定基础。 | 朱永明 郭家欣 Ahsan Siraj | 2019 | 中州学刊2019，，5： | 4 |
| 16 | Role of dietary phytochemicals in modulation of miRNA expression:Natural swords combating breast cancer显示文摘The National Cancer Institute had projected breast cancer(BC) as one of the topmost prevalent malignancies around the globe.In many cases,BC becomes resistant to chemotherapy,radiation and hormonal therapies.Traditional BC therapies are associated with adverse side effects,drug resistance and recurrence.Extensive research work has shown that these dietary phytochemicals(DPs) may exert therapeutic effects by regulating the miRNA expression.A large number of DPs have been researched as miRNA regulatory agents against BC and some other DPs have not yet been tested against BC.We have discussed the effects of curcumin,diallyl disulphide,3,3′ diindolylmethane,ellagic acid,genistein,indole-3-carbinol,quercetin,resveratrol,and sulforaphane on regulation of expression of BC miRNAs in a wide range of in vitro and in vivo models.We have also shown some of the possible DPs(Oleanolic acid,capsaicin,benzyl isothiocyanate,epigallocatechin gallate,phenethyl isothiocyanate and ursolic acid) that have shown miRNA regulatory activities and have not yet been tested against BC miRNAs.Finally,current limitations,challenges,future perspectives of DPs and BC research are also critically discussed. | Banzeer Ahsan Abbasi Javed Iqbal Tariq Mahmood Ali Talha Khalil Barkat Ali Sobia Kanwal Sayed Afzal Shah Riaz Ahmad | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，9： | 3 |
| 17 | HMG:心脏病发作的记忆储存在我们的基因中显示文摘遗传因素和环境因素影响我们的心血管疾病风险。如今。在一项新的研究中,来自瑞典乌普萨拉大学的研究人员发现心脏病发作的记忆能够通过表观遗传变化储存在我们的基因中。相关研究结果在线发表在Human Molecular Genetics期刊上。 | Mathias Rask-Andersen David Martinsson Muhammad Ahsan Stefan Enroth Weronica E. Ek Ulf Gyllensten sa Johansson | 2016 | 现代生物医学进展2016，16，31： | 3 |
| 18 | Tall Buildings with Dynamic Facade Under Winds显示文摘Burgeoning growth of tall buildings in urban areas around the world is placing new demands on their performance under winds.This involves selection of the building form that minimizes wind loads and structural topologies that efficiently transfer loads.Current practice is to search for optimal shapes,but this limits buildings with static or fixed form.Aerodynamic shape tailoring that consists of modifying the external form of the building has shown great promise in reducing wind loads and associated structural motions as reflected in the design of Taipei 101 and Burj Khalifa.In these buildings,corner modifications of the cross-section and tapering along the height are introduced.An appealing alternative is to design a building that can adapt its form to the changing complex wind environment in urban areas with clusters of tall buildings,i.e.,by implementing a dynamic facade.To leap beyond the static shape optimization,autonomous dynamic morphing of the building shape is advanced in this study,which is implemented through a cyber–physical system that fuses together sensing,computing,actuating,and engineering informatics.This approach will permit a building to intelligently morph its profile to minimize the source of dynamic wind load excitation,and holds the promise of revolutionizing tall buildings from conventional static to dynamic facades by taking advantage of the burgeoning advances in computational design. | Fei Ding Ahsan Kareem | 2020 | Engineering2020，6，12： | 3 |
| 19 | Source identification, contamination status and health risk assessment of heavy metals from road dusts in Dhaka, Bangladesh显示文摘In this study, concentrations of Cr, Mn, Ni, Cu, Zn, Cd and Pb were determined in road dusts collected from different locations in Dhaka to assess source, contamination status and health risk. Energy-dispersive X-ray fluorescence spectroscopy and energy-dispersive X-ray spectroscopy were used to determine Cr, Mn, Ni, Cu, Zn, Cd and Pb and their mean concentrations were 162.27 ± 29.46, 721.18 ± 180.14, 35.65 ± 12.55, 104.56 ± 128.33, 515.32 ± 321.90,BDL, and 342.82 ± 591.20 mg/kg, respectively. Among the heavy metals, highest concentrations of Cu, Zn and Pb were found at urban sites-7(municipal waste dumping) and 8(medical waste incineration). Highest concentration of Cr followed by Cu and Zn was found at site-5(Tejgaon, urban). Principal component analysis revealed that anthropogenic activities are the potential sources for Cr, Ni, Cu, Zn and Pb while earth crust for Mn. Pollution index and pollution load index results suggested that all the sites were contaminated and/or degraded by Cr, Cu, Zn and Pb except sites-9(urban), 10(sub-urban), 11(rural) while sites-7 and 8(urban) were extremely degraded. For noncarcinogenic health risk, hazard quotient values for dermal were higher compared to that of inhalation/ingestion. Though hazard index values were less than 1 at all the sites, these were at least one order of magnitude higher for children group than that of adult group, thus the children group may face more noncarcinogenic health risk at sites -7 and 8. Values of incremental lifetime cancer risk were from 10to 10showed no carcinogenic health risk by road dusts contaminated with the heavy metals. | Aklima Nargis Ahsan Habib Md Nazrul Islam Kai Chen Md Shafiqul Islam Sarker A N M Al-Razee Wenbin Liu Guorui Liu Minggang Cai | 2022 | Journal of Environmental Sciences2022，34，11： | 3 |
| 20 | Diagnostic value of serum human epididymis protein 4 in esophageal squamous cell carcinoma显示文摘BACKGROUND Numerous studies have demonstrated that human epididymis protein 4(HE4)is overexpressed in various malignant tissues including ovarian,endometrial,lung,breast,pancreatic,and gastric cancers.However,no study has examined the diagnostic impact of HE4 in patient with esophageal squamous cell carcinoma(ESCC)until now.AIM To analyze the value of four serum tumor markers for the diagnosis of ESCC,and examine the associations of serum levels of HE4 with ESCC patients’clinicopathological characteristics.METHODS The case group consisted of 80 ESCC patients,which were compared to a control group of 56 patients with benign esophageal disease.Serum levels of HE4,carcinoma embryonic antigen(CEA),alpha fetal protein,and carbohydrate antigen 19-9(CA19-9)were detected by ELISA.The associations of serum HE4 levels with ESCC patients’clinicopathological characteristics such as gender,tumor location,and pathological stage were also examined after operation.RESULTS The result of ELISA showed that serum HE4 level was significantly higher in the patients with ESCC than in the controls,and the staining intensity was inversely correlated with the pathological T and N stages.Serum HE4 levels had a sensitivity of 66.2%and specificity of 78.6%when the cutoff value was set at 3.9 ng/mL.Moreover,the combined HE4 and CA19-9 increased the sensitivity to 83.33%,and interestingly,the combination of HE4 with CEA led to the most powerful sensitivity of 87.5%.Furthermore,A positive correlation was observed between HE4 serum levels and pathological T and N stages(P=0.0002 and 0.0017,respectively),but there was no correlation between HE4 serum levels and ESCC patient gender(P=0.4395)or tumor location(P=0.6777).CONCLUSION The results of this study suggest that detection of serum HE4 levels may be useful in auxiliary diagnosis and evaluation of the progression of ESCC. | Shi-Yuan Liu Muhammad Ahsan Bilal Jian-Hong Zhu Shao-Min Li | 2020 | World Journal of Gastrointestinal Oncology2020，12，10： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员