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| 1 | Veno occlusive disease: Update on clinical management显示文摘Hepatic veno-occlusive disease is a clinical syndrome characterized by hepatomegaly, ascites, weight gain and jaundice, due to sinusoidal congestion which can be caused by alkaloid ingestion, but the most frequent cause is haematopoietic stem cell transplantation (STC) and is also seen after solid organ transplantation. The incidence of veno occlusive disease (VOD) after STC ranges from 0 to 70%, but is decreasing. Survival is good when VOD is a mild form, but when it is severe and associated with an increase of hepatic venous pressure gradient > 20 mmHg, and mortality is about 90%. Prevention remains the best therapeutic strategy, by using non-myeloablative conditioning regimens before STC. Prophylactic administration of ursodeoxycholic acid, being an antioxidant and antiapoptotic agent, can have some benefit in reducing overall mortality. Defibrotide, which has pro-fibrinolytic and antithrombotic properties, is the most effective therapy; decompression of the sinusoids by a transjugular intrahepatic portosystemic shunt (TIPS) can be tried, especially to treat VOD after liver transplantation and when multiorgan failure (MOF) is not present. Liver transplantation can be the last option, but can not be considered a standard rescue therapy, because usually the concomitant presence of multiorgan failure contraindicates this procedure. | M Senzolo G Germani E Cholongitas P Burra AK Burroughs | 2007 | World Journal of Gastroenterology2007，13，29： | 19 |
| 2 | New insights into the coagulopathy of liver disease and liver transplantation显示文摘The liver is an essential player in the pathway of coagulation in both primary and secondary haemostasis. Only von Willebrand factor is not synthetised by the liver, thus liver failure is associated with impairment of coagulation. However, recently it has been shown that the delicate balance between pro and antithrombotic factors synthetised by the liver might be reset to a lower level in patients with chronic liver disease. Therefore, these patients might not be really anticoagulated in stable condition and bleeding may be caused only when additional factors, such as infections, supervene. Portal hypertension plays an important role in coagulopathy in liver disease, reducing the number of circulating platelets, but platelet function and secretion of thrombopoietin have been also shown to be impaired in patients with liver disease. Vitamin K deficiency may coexist, so that abnormal clotting factors are produced due to lack of gamma carboxylation. Moreover during liver failure, there is a reduced capacity to clear activated haemostatic proteins and protein inhibitor complexes from the circulation. Usually therapy for coagulation disorders in liver disease is needed only during bleeding or before invasive procedures. When end stage liver disease occurs, liver transplantation is the only treatment available, which can restore normal haemostasis, and correct genetic clotting defects, such as haemophilia or factor V Leiden mutation. During liver transplantation haemorrage may occur due to the pre-existing hypocoagulable state, the collateral circulation caused by portal hypertension and increased fibrinolysis which occurs during this surgery. | M Senzolo P Burra E Cholongitas AK Burroughs | 2006 | World Journal of Gastroenterology2006，12，48： | 12 |
| 3 | 中心和外周动脉脉搏波传导速度测量的重复性:社区动脉粥样硬化风险研究显示文摘通过脉搏波传导速度(pulsewavevelocity,PwV)检测动脉硬化程度是当前对高血压和心血管病风险评估和分层所日渐常用的方式。颈股动脉脉搏波传导速度(catroidfemoralarteryPWV,cfPWV)是一项公认的测定中心动脉硬化程度的方式。 | Meyer ML Tanaka H Palta P Patel MD Camplain R Couper D Cheng S Al Qunaibet A Poon AK Heiss G 陈云 叶鹏 | 2016 | 中华高血压杂志2016，24，5： | 6 |
| 4 | 正常高值血压者心脏迷走神经调节、氧化应激和心血管疾病危险因素的横断面研究显示文摘高血压是心血管疾病的可控危险因素之一,与氧化应激增强和心脏迷走神经调节减弱相关。同样,正常高值血压也与心血管事件的风险增加相关。该研究探索正常高值血压和心脏迷走神经调节、氧化应激及心血管危险因素之间的相关性。 | Thiyagarajan R Pal P Pal GK Subramanian SK Bobby Z Das AK Trakroo M 罗冬梅 叶鹏 | 2013 | 中华高血压杂志2013，21，9： | 5 |
| 5 | Probucol promotes func- tional reendothelialization in balloon-injured rabbit aortas 显示文摘 | Lau AK Leichtweis SB Hume P | 2003 | Cir- culation2003，107，15： | 1 |
| 6 | A bcr-3 isoform of RARalpha-PML potentiates the development of PML-RARalpha-driven acute promyelocytic leukemia显示文摘 | Pollock JL Westervelt P Kurichety AK | 1999 | Proc Natl Acad Sci USA1999，96，15： | 1 |
| 7 | Serum cholesterol and mortality in patients with multiple organ failure显示文摘 | Fraunberger P Nagel D Walli AK | 2000 | Crit Care Med2000，28，： | 1 |
| 8 | Deterioration in quality of life(QoL) in patients with malignant ascites:results from a phase II/III study comparing paracentesis plus catumaxomab with para- centesis alone显示文摘 | Wimberger P Gilet H Gonschior AK | 2012 | Ann Oncol2012，23，8： | 1 |
| 9 | Status of Vi gene, its expression and Salmonella pathogenicity island (SPI-7) in Salmonella typhi in India显示文摘 | Maurya P Gulati AK Nath G | 2010 | Southeast Asian J Trop Med Public Health2010，41，4： | 1 |
| 10 | A causal role for E-cadherin in the transition from adenoma to carcinoma显示文摘 | Perl AK Wilgenbus P Dahl U | 1998 | Nature1998，392，11： | 1 |
| 11 | T cells from human allergen -induced late asthmatic responses express IL - 12 receptor beta 2 subunit mRNA and respond to IL- 12 in vitro显示文摘 | Varga EM Wachholz P Nouri AK | 2000 | J Immunol2000，165，5： | 1 |
| 12 | FIGO Staging system for endometrial cancer: added benefits of MR imaging 显示文摘 | Beddy P O'Neill AC Yamamoto AK | 2012 | Radiograph- ics2012，32，1： | 1 |
| 13 | Choroidal thickness in nonar- teritie anterior ischemic optic neuropathy 显示文摘 | Schuster AK Steinmetz P Forster TM | 2014 | Am J Ophthalmol2014，158，6： | 1 |
| 14 | Genome-wide analysis of thiourea-modulated salinity stress-responsive transcripts in seeds of Brassica juncea:Identification of signaling and effector components of stress tolerance显示文摘 | SRIVASTAVA AK RAMASWAMY NK SUPRASANNA P | 2010 | Annals of Botany2010，106，： | 1 |
| 15 | Microbial Toll-like receptor ligands differentially regulate CXCL10/IP-10 expression in fibroblasts and mononuclvar lvukocytes in synergy with IFN-γ and provide a mechanism for enhanced synovial chemokine levels in septic arthritis显示文摘 | Proost P Vynckier AK Mahieu F | 2003 | Eur J Immunol2003，33，11： | 1 |
| 16 | Increased hMSH2 protein expression in glioblastoma multiforme显示文摘 | Srivastava T Chattopadhyay P Mahapatra AK | 2004 | J Neurooncol2004，66，12： | 1 |
| 17 | Chemotherapy of fungus infections:Part II-Aliphatic& aromatic acid hydra zones and alkyl or aryl thiosemicarbazones of 5-chloro salicylaldehyde显示文摘 | Bhat AK Bhamaria R P Bellare RA | 1967 | Indian J Chem1967，5，： | 1 |
| 18 | Growing skull fractures显示文摘 | Djientcheu Vde P Njamnshi AK Ongolo-Zogo P | 2006 | Childs Nerv Syst2006，22，7： | 1 |
| 19 | Adhesion proteins of Mycoplasma pneumoniae显示文摘 | Chaudhry R Varshney AK Malhotra P | 2007 | Front Biosci2007，12，： | 1 |
| 20 | Sequential versus simuhaneous biventricular resynchronization for severe heart failure: evaluation by tissue Doppler imaging 显示文摘 | Sogaard P Egeblad H Pedersen AK et at | 2002 | Circulation2002，106，： | 1 |
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