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| 1 | 通过使用转基因小鼠来了解沃尔夫/附睾管发育的正常与异常显示文摘沃尔夫/附睾管的发育对雄性生殖系统的正常功能以及相应的男性生育力至关重要。附睾的发育过程复杂,它起始于一个短暂的胚肾,而后中肾形成,中肾进一步在雄激素与生长激素的影响下经历形态发生最终形成附睾。因此,要了解它完整的发育过程需要一个广泛的、多学科的视角。这篇综述着力探讨表现出沃尔夫管与中肾发育异常的小鼠模型、这些小鼠模型对了解生殖道发育的重要性、以及这些模型如何帮助我们了解诸如先天性肾脏和尿路畸形(CAKUT)这样的人类临床异常表现。 | Aki Murashima Bingfang Xu Barry T Hinton | 2015 | Asian Journal of Andrology2015，17，5： | 4 |
| 2 | 缺血期补充硝酸甘油对离体大鼠心脏心肌缺血再灌注损伤的作用显示文摘目的:观察离体大鼠心脏缺血期补充一氧化氮(NO)供体对缺血再灌注损伤的影响。 方法:将26只离体大鼠心脏缺血30分,再灌注60分。分为两组,用药组(15只)及对照组(11 只)。用药组于缺血期给予4.4×10- 3 mm ol/L硝酸甘油(nitroglycerin,NTG,一种NO供体),碳酸氢盐缓冲液灌注。对照组仅给予碳酸氢盐缓冲液灌注。全部心脏均测定NO释放量、肌酸激酶漏出量及(或)心脏功能。 结果:用药组大鼠心脏,使用NTG表现为两种效应。其中部分大鼠心脏(非心室颤动组,n= 7),NTG增加肌酸激酶漏出量,减弱再灌注期心脏功能的恢复,伴随缺血期NO释放量的增加。对另一部分大鼠心脏(心室颤动组,n= 8),NTG减少肌酸激酶的释放,但心脏于再灌注期持续心室颤动,缺血期NO释放量无明显增加。 结论:缺血期给予同一剂量NTG对心肌缺血再灌注损伤产生双重效应,既可增加心肌损伤,又可减轻心肌损伤。 | 刘海波 Takayuki T su ji Fum io Y am amoto Tosh ia Fujisato Hidekazu H irai Fu jio Miyaw aki | 1999 | 中国循环杂志1999，14，4： | 3 |
| 3 | Hepatitis B-related events in autologous hematopoietic stem cell transplantation recipients显示文摘AIM: To investigate the frequency of occult hepatitis B, the clinical course of hepatitis B virus (HBV) reactivation and reverse seroconversion and associated risk factors in autologous hematopoietic stem cell transplantation (HSCT) recipients. METHODS: This study was conducted in 90 patients undergoing autologous HSCT. Occult HBV infection was investigated by HBV-DNA analysis prior to transplantation, while HBV serology and liver function tests were screened prior to and serially after transplantation. HBV-related events including reverse seroconversion and reactivation were recorded in all patients. RESULTS: None of the patients had occult HBV prior to transplantation. Six (6.7%) patients were positivefor HBV surface antigen (HBsAg) prior to transplantation and received lamivudine prophylaxis; they did not develop HBV reactivation after transplantation. Clinical HBV infection emerged in three patients after transplantation who had negative HBV-DNA prior to HSCT. Two of these three patients had HBV reactivation while one patient developed acute hepatitis B. Three patients had anti-HBc as the sole hepatitis B-related antibody prior to transplantation, two of whom developed hepatitis B reactivation while none of the patients with antibody to HBV surface antigen (anti-HBs) did so. The 14 anti-HBs-and/or anti-HBc-positive patients among the 90 HSCT recipients experienced either persistent (8 patients) or transient (6 patients) disappearance of anti-HBs and/or anti-HBc. HBsAg seroconversion and clinical hepatitis did not develop in these patients. Female gender and multiple myeloma emerged as risk factors for loss of antibody in regression analysis (P < 0.05). CONCLUSION: Anti-HBc as the sole HBV marker seems to be a risk factor for reactivation after autologous HSCT. Lamivudine prophylaxis in HbsAg-positive patients continues to be effective. | zcan eneli Zübeyde Nur zkurt Kadir Acar Seyyal Rota Sahika Zeynep Aki Zeynep Arzu Yegin Münci Yagci Seren zenirler Gülsan Türkz Sucak | 2010 | World Journal of Gastroenterology2010，16，14： | 3 |
| 4 | Assessment of symphysis morphology as a predictor of the direction of mandibular growth显示文摘 | Aki T Nanda RS Currier GF | | 0，，01： | 1 |
| 5 | Regional change of coda Q in oceanic lithosphere显示文摘 | Jin A Cao T Aki K | 1985 | J Grephys Res1985，90，： | 1 |
| 6 | Production of araehidonic acid by filamentous fungus, Mortierella alliacea strain YN-15显示文摘 | AKI T NAGAGATA Y ISHIHARA K | 2001 | J Am Oil Chem Soc2001，78，： | 1 |
| 7 | Regional change of coda Q in oceanic lithosphere显示文摘 | Jin A Cao T Aki K | 1985 | J Grephys Res1985，，86： | 1 |
| 8 | Polycondensation of dicarboxylic acids and diols in water catalyzed by surfactant-combined catalysts and successive chain extension显示文摘 | Akinori T Aki T Tadamichi H | 2006 | Biomacromolecules2006，7，： | 1 |
| 9 | Assigning probability gain for precursors of four large Chinese earthquakes显示文摘 | Cao T Aki K | 1983 | Journal of Geophysical Research1983，88，3： | 1 |
| 10 | ERK1/2 regulates intracellular ATP levels through a-enolase expression in cardiomyocytes exposed to ischemic hypoxla and reoxygenation 显示文摘 | Mizukami Y Iwamatsu A Aki T | 2004 | J Biol Chem2004，279，50： | 1 |
| 11 | Lecithinized brain-derived neurotrophic factor promotes the differentiation of embryonic stem cells in vitro and in vivo 显示文摘 | Aki K Toshiaki N Mitsuko T | 2005 | Biochem Biophys Res Commun2005，328，4： | 1 |
| 12 | Plane strain analytical solutions for a functionally graded elastic-plastic pressurized tube显示文摘 | ERASLAN A N AKIS T | 2006 | International Journal of Pressure Vessels and Piping2006，83，： | 1 |
| 13 | Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2显示文摘 | Aki T Yamaguchi K Fujimiya T | 2003 | Oncogene2003，22，52： | 1 |
| 14 | Emotional stress activates MAP kinase in the rat heart显示文摘 | Ueyama T Aki T Senba E | 2001 | Life Sci2001，69，16： | 1 |
| 15 | Elastoplastic analysis of functionally graded spherical pressure vessels显示文摘 | AKIS T | 2009 | Computational Materials Science2009，46，： | 1 |
| 16 | Production of arachidonic acid by filamentous fungus, Mortierella alliacea strain YN-15 显示文摘 | Aki T Nagahata Y Ishihara K | 2001 | J Am Oil Chem Soc2001，78，6： | 1 |
| 17 | Metastatic potential of cancer stem cells in head and neck squamous cell carcinoma显示文摘 | Davis S J Divi V Owen J H Bradford C R Carey T E Papager akis S | 2010 | Arch Otolaryngol Head Neck Surg2010，136，： | 1 |
| 18 | Differential response to low temperature of two △^6-fatty acid desaturas- es from Mucor circinelloides显示文摘 | Miehinaka Y Aki T Shimauchi T | 2003 | Applied Microbiology and Biotechnology2003，62，： | 1 |
| 19 | Combined choriocarcinoma and adenocarcinoma of the lung显示文摘 | Aki T Yoshida H | 1989 | Acta Pathol Jpn1989，39，： | 1 |
| 20 | A Probabilistic Approach to WLAN User Location Estimation显示文摘 | Roos T Myllym '' aki P Tirri H | 2002 | International Joumal of Wirelesslnfonnation Networks2002，9，3： | 1 |
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