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| 1 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 2 | Determining Lyapunov Exponents from a Time Series显示文摘 | Alan W Jack B S Harry L S | 1985 | Physica D1985，16，： | 1 |
| 3 | Determining Lyapunov exponents from a time series显示文摘 | Wolf Alan Swift Jack B Swinney Harry L | 1985 | Physica D1985，16，： | 1 |
| 4 | Total phenol, flavonoid, proanthocyanidin and vitamin C levels and antioxidant activities of Mauritian vegetables显示文摘 | Theeshan B Amitabye L R Alan C | 2004 | Journal of the Science of Food and Agriculture2004，84，9： | 1 |
| 5 | Weakly hard real-time systems 显示文摘 | Guillem B Alan B Albert L | 2001 | IEEE Transactions on Computers2001，50，4： | 1 |
| 6 | Influence of prohexadione calcium on pod yield and pod loss of peanut显示文摘 | Joshua B B David L J Alan C Y | 2002 | Agronomy Journal2002，94，2： | 1 |
| 7 | Creep and microstructure of magnesium-aluminum-calcium based alloys 显示文摘 | Alan A L Michael P B Bob R P | 2002 | Metallurgical and Materials Transactions2002，33，： | 1 |
| 8 | Mercury(11) immobilized on car-bon nanotubes: synthesis, characterization and redox properties 显示文摘 | ALAN M B MIAO W COLIN L R | 2000 | Langmuir2000，16，14： | 1 |
| 9 | Just i- magine: new paradigms for medical education显示文摘 | Neil B Mehta Alan L Hull James B Young | 2013 | Academic Medicine2013，，10： | 1 |
| 10 | Characterization of thematioxidant functions of flavonoids and proan- thocyanidins in Mauritianblack teas显示文摘 | AMITABYE L R THEESHAN B ALAN C | 2005 | Food Research International2005，38，： | 1 |
| 11 | Fault-tolerant homopolar magnetic beatings显示文摘 | MING H L ALAN B P | 2004 | IEEE Transactions on Magnetics2004，40，5： | 1 |
| 12 | Central bank credibility:why do we care?How do we build it?显示文摘 | Alan B L | 2000 | The American Economic Review2000，90，5： | 1 |
| 13 | Cold storage for plug production 显示文摘 | Karen L B Gast Alan B Stevens | 1994 | Horticulture1994，20，3： | 1 |
| 14 | Determining Lyapunov Exponents from a Time Series 显示文摘 | ALAN W SWIFT J B SWINNEY H L | 1985 | Physica1985，16，： | 1 |
| 15 | Electric-Field Carbon Nanotubes in Different Dielectric Solvents显示文摘 | Liu Xianming Spencer John L Kaiser Alan B Arnold W Mike | 2004 | Current Applied Physics2004，4，： | 1 |
| 16 | Systematic Review of the Symptom Burden,Quality of Life Impairment and Costs Associated with Peptic Ulcer Disease显示文摘 | Alan B Grigorios L | 2010 | The American Journal of Medicine2010，123，4： | 1 |
| 17 | Estimation and mapping of forest stand density, volume, and cover type using the k-nearest neighbors method 显示文摘 | HECTOR F L ALAN R E MARVIN E B | 2001 | Remote Sensing of Environment2001，77，3： | 1 |
| 18 | Creep and microstructure of magnesium aluminum-calcium based alloys 显示文摘 | ALAN A L MICHAEL P B BOB R | 2002 | Metallurgical and Materials Transaetions2002，33，： | 1 |
| 19 | Maximizing the benefits of project work in foreign language classrooms 显示文摘 | Alan B & Stoller F L | 2005 | English Teaching Forum2005，43，4： | 1 |
| 20 | Determining lyapunov exponents from a time series 显示文摘 | Alan Wolf Jack B Swift Harry L Swinney | 1985 | Physica D1985，16，： | 1 |
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