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| 1 | 世界各地动脉粥样硬化血栓形成门诊患者心血管危险因素的流行及诊治情况显示文摘背景:动脉粥样硬化血栓形成是导致心血管疾病和死亡的主要原因。至今,尚无国际数据库阐述动脉粥样硬化血栓形成患者动脉硬化危险因素的特征和治疗强度。
目的:确定动脉粥样硬化危险因素的发生及治疗在世界许多国家是否具有可比性。设计、地点及参试者:“降低动脉粥样硬化血栓形成保持健康研究”(Reduction of Atherothrombosis for Continued Health,REACH)搜集了动脉粥样硬化危险因素及治疗情况的数据。从2003年到2004年,44个国家、5473位内科从业医师总共发现67888例年龄≥45岁的动脉病患者(冠心病[coronaryartery disease,CAD],n=40258;脑血管病,n=18843;周围动脉病,n=8273)或≥3个动脉粥样硬化血栓形成危险因素(n=12389)。主要观测指标:动脉粥样硬化危险因素的基线发生率、药物应用情况及危险因素控制程度。结果:全世界动脉粥样硬化血栓形成患者具有相似的危险因素,即高血压(81.8%)、高胆固醇血症(72.4%)以及糖尿病(44.3%)的比例高。超重(39.8%)、肥胖(26.6%)以及病态肥胖(3.6%)的发生率在大部分地区相似,但是以北美最高(超重:37.1%,肥胖:36.5%,病态肥胖:5.8%;与其他地区比较P〈0.001)。患者采用他汀(总共69.4%;范围:从脑血管病的56.4%到CAD的76.2%)、抗血小板治疗(总共78.6%;范围:从≥3个危险因素的53.9%到CAD的85.6%)及其他循证(降低危险)普遍不足。确诊有血管病的患者在吸烟者为数可观(14.4%)。高血压病治疗不足(基线50.0%血压升高)、高血糖诊断不足(4.9%)以及空腹血糖受损(其中36.5%不知已有糖尿病)均很常见。在有症状的动脉粥样硬化血栓形成患者中,15.9%是有症状的多血管疾病患者。
结论:这项当代大型国际数据库研究显示,在世界许多地区典型心血管危险因素的发生是一致且常见的,但是大多治疗不足、控制不得力。 | Deepak L. Bhatt, MD P. Gabriel Steg, MD E. Magnus Ohman, MD Alan T. Hirsch, MD Yasuo Ikeda, MD Jean-Louis Mas, MD Shinya Goto, MD Chlau-Suong Liau, MD, PhD Alain J. Richard, MD, PhD Joachim Roether, MD Peter W. F. Wilson, MD 徐成斌(译) | 2007 | 美国医学会杂志(中文版)2007，26，1： | 5 |
| 2 | INTERMETALLIC ALLOYS AND COMPOSITES FOR THE 21ST CENTURY: A BASIC ENERGY SCIENCES PROGRAM OF THE U. S. DEPARTMENT OF ENERGY显示文摘Progress has been made in intermetallic alloys over the past decade and a half, but intermetallics remain a relatively unexplored class of materials for energy applications. Hence, they offer considerable opportunities both for scientific research on fundamental structural property processing relationships and for technological development. The Department of Energy supports a program of scientific research on intermetallic alloys such as the nickel and iron aluminides and is establishing new research efforts in silicides and Laves phases through the program of the Division of Materials Sciences, of the Office of Basic Energy Sciences. Areas of research include theory and materials simulation, microalloying, high resolution sudies of structure and composition, mechanical properties, point defects and dislocation mechanics, phase transformations, and processing. Research is conducted through programs at the Department of Energy National Laboratories and through grants to academic and industrial researchers.Research results from Division of Materials Sciences programs have provided the basis and transportation. In addition, a cooperative effort between research groups has been established as a project on intermetallic materials under the Center of Excellence in Synthesis and Processing of Advanced Materials. | Alan L. Dragoo Division of Materials Sciences, Office of Basic Energy Sciences, U.S.Department of Energy, Germantown, MD 2087-1290, U.S.A. | 1999 | 中国有色金属学会会刊:英文版1999，9，S1： | 3 |
| 3 | Levels of Expression of P-Selectin, E-Selectin, and Intercellular Adhesion Molecule-1 in Coronary Atherectomy Specimens from Patients With Stable and Unstable Angina Pectoris显示文摘 | Alan N Tenaglia MD Andrew J Buda MD Robert G Wilkins MD Michael K Barron MD Paul R Jeffords BS Khoa Vo BS Maureen O Jordan BS Barry A Kusnick MD David J Lefer PhD | 1997 | The American Journal of Cardiology1997，，6： | 1 |
| 4 | Suicide prevention strategies, a systematic review 显示文摘 | John Mann MD Alan Apter MD Jose Bertolote MD | 2005 | JAMA2005，294，26： | 1 |
| 5 | Effect of somatostatin analog octreotide on human sphincter of Oddi显示文摘 | Kenneth F. Binmoeller MD Remy Dumas MD Alan G. Harris MD Prof. J. P. Delmont MD | 1992 | Digestive Diseases and Sciences1992，，5： | 1 |
| 6 | Early Results with Infrainguinal Cutting Balloon Angioplasty Limits Distal Dissection显示文摘 | Jamal F. Rabbi MD Ravi P. Kiran MD Gregory Gersten MD Stanley J. Dudrick MD Alan Dardik MD PhD | 2004 | Annals of Vascular Surgery2004，，6： | 1 |
| 7 | Multiresidue methods for the analysis of pharmaceuticals, personal care products and illicit drugs in surface water and waste water by solid-phase extraction and ultra performance liquid chromatography-electrospray tandem mass spectrometry显示文摘 | Barbara KH Richard MD Alan JG | 2008 | Anal Bioanal Chem2008，391，： | 1 |
| 8 | Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure 显示文摘 | Alan S Malsel MD Padma KY | 2002 | N Engl J Med2002，347，3： | 1 |
| 9 | Prospective external validation of the clinical effectiveness of an emergency department-based early goal directed therapy protocol for severe sepsis and septic shock显示文摘 | Alan E Jones MD | | 0，，02： | 1 |
| 10 | Brain heart intemction显示文摘 | Alan M Davis MD Benjamin H | 1993 | Texas Heart Institute J1993，20，2： | 1 |
| 11 | Suicide prevention strategies, a systematic review 显示文摘 | John Mann MD Alan Apter MD Jose Bertolote MD | 2005 | JAMA2005，294，26： | 1 |
| 12 | Iatrogenic arterioportal fistulae: Diagnosis and management显示文摘 | Ferda F. Isik MD Alan J. Greenfield MD Jon Guben MD Desmond Birkett MD James O. Menzoian MD | 1989 | Annals of Vascular Surgery1989，，1： | 1 |
| 13 | Connective tissue growth factor: A new and important player in the pathogenesis of fibrosis显示文摘 | Andrew Leask PhD MD Alan Holmes BSc David J. Abraham PhD | 2002 | Current Rheumatology Reports2002，，2： | 1 |
| 14 | Accurate Lymph Node Staging is of Greater Prognostic Importance Than Subclassification of the T2 Category for Gastric Adenocarcinoma显示文摘 | Abeezar I. Sarela MD Alan D. Turnbull MD Daniel G. Coit MD David Klimstra MD Murray F. Brennan MD Martin S. Karpeh MD | 2003 | Annals of Surgical Oncology2003，，7： | 1 |
| 15 | Diagnosis and treatment drugs five years later desmopressin 显示文摘 | Richardson MD Alan G | 1985 | Annals of Internal medicine1985，103，： | 1 |
| 16 | Rapid measurement of B type natriuretic peptide in the emergency diagnosis of heart failure显示文摘 | Alan S Malsel MD Padma KY | 2002 | N Engl J Meal2002，347，3： | 1 |
| 17 | Neoadjuvant Chemoradiotherapy for Adenocarcinoma of the Pancreas: Treatment Variables and Survival Duration显示文摘 | Tara M. Breslin MD Kenneth R. Hess PhD Dana B. Harbison MD Marina E. Jean MD Karen R. Cleary MD Alan P. Dackiw MD Robert A. Wolff MD James L. Abbruzzese MD Nora A. Janjan MD Christopher H. Crane MD J. Nicolas Vauthey MD Jeffrey E. Lee MD Peter W. T. Piste | 2001 | Annals of Surgical Oncology2001，，2： | 1 |
| 18 | Brain-heart interaction 显示文摘 | Alan M Davis MD Benjamin H | 1993 | Texas Heart Institute J1993，20，2： | 1 |
| 19 | Brainstem mechanisms of hypertension: Role of the rostral ventrolateral medulla显示文摘 | Alan F. Sved PhD Satoru Ito MD Judith C. Sved PhD | 2003 | Current Hypertension Reports2003，，3： | 1 |
| 20 | Connective tissue growth factor: A new and important player in the pathogenesis of fibrosis显示文摘 | Andrew Leask PhD MD Alan Holmes BSc David J. Abraham PhD | 2002 | Current Rheumatology Reports2002，，2： | 1 |
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