|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation显示文摘Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of autoimmunity.Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)responses.Recently,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose IL-2.Therefore,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)development.Development of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by IL-2.Therefore,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg development.OX40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell subsets.Relative to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature tTregs.In ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR signaling.These novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity. | Prabhakaran Kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein Ajay V Maker Bellur S Prabhakar | 2019 | Cellular & Molecular Immunology2019，16，2： | 4 |
| 2 | 新加坡成人慢性呼吸系统疾病患者6分钟步行距离的最小临床重要差异值研究(英文)显示文摘目的:6 min步行距离(6MWD)是临床上常见的功能性运动能力测试,特别是对于慢性呼吸系统疾病患者。一些文献记载了关于白种人的6MWD的最小临床重要差异(MCID),但对亚洲人群的相关信息未见记载。本研究旨在建立亚洲成人慢性呼吸道疾病患者6MWD的最小临床重要差异。方法:采用'锚定'法和'分布'法对新加坡中央医院肺康复计划登记处的资料进行了分析。'锚定'法收集确诊为慢性呼吸道疾病的患者50例,其中男38例,女12例;平均年龄(64.2±12.3)岁,通过电话采访及使用整体变化评估量表(GROC)评价患者肺康复计划后的自觉改善程度,再将患者在肺康复计划中6MWD的改变数值与相对应的患者自觉改善程度进行比较,这种关系用操作特征曲线(ROC)统计表示。通过'分布'法确定6MWD的MCID,从门诊和住院的肺康复计划(PRP)参与者中检索医疗记录136例,其中男103例,女33例;平均年龄(60.1±14.1)岁。结果 :ROC曲线表明6MWD出现临床显著性变化的最佳临界值为17.4 m,其对应的敏感性为79.4%,特异性为81.3%,阳性似然比为4.23。由'分布'法确定6MWD的最小临床重要差异值为18.6 m。结论:18.6 m为新加坡华人6MWD的最小临床重要差异的估计值。 | Meredith T L YEUNG Alan W P WONG Katherine S L HUANG Alice Y M JONES | 2015 | 康复学报2015，25，1： | 3 |
| 3 | Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study显示文摘 | Mark S Pearce Jane A Salotti Mark P Little Kieran McHugh Choonsik Lee Kwang Pyo Kim Nicola L Howe Cecile M Ronckers Preetha Rajaraman Alan W Craft Louise Parker Amy Berrington de González | 2012 | The Lancet . 2012 (9840)2012，，： | 3 |
| 4 | Determining Lyapunov Exponents from a Time Series显示文摘 | Alan W Jack B S Harry L S | 1985 | Physica D1985，16，： | 1 |
| 5 | The vehicle routing problem with stochastic demand and duration constraints显示文摘 | ALAN L E JUAN C M MARTIN S | | 0，，4： | 1 |
| 6 | Software strategies for portable computer energy management 显示文摘 | Jacob R L Alan J S | 1998 | IEEE Personal Communications1998，5，3： | 1 |
| 7 | Damage control orthopedics:evolving concepts in the treatment of patients who have sustained orthopedics trauma显示文摘 | Craig S Robins Hans-Christopher Alan L Jones | 2005 | Journal of Bone and Joint Surgery2005，87，2： | 1 |
| 8 | 查看详情显示文摘 | Lehotay S J Kate(r)ina M Alan R L | | 0，，02： | 1 |
| 9 | Highly concentrated,intercalated silicate nanocomposites:synthesis and characteri-zation显示文摘 | Adam S Z Terrence C C Alan J L | 2003 | Macromolecules2003，36，5： | 1 |
| 10 | Short bowel syndrome and crohn’s disease显示文摘 | Jon S Thompson Kishore R Iyer John K DiBaise Renee L Young Cindy R Brown Alan N Langnas | 2003 | Journal of Gastrointestinal Surgery2003，，8： | 1 |
| 11 | Subtalar arthroscopie proee-dures for the treatment of subtalar pathologic condi- tions: 115 consecutive case 显示文摘 | ALAN J H LEE S K KIM I L | 2009 | Orthopedics2009，32，12： | 1 |
| 12 | Use and efficacy of low close ketamine in the management or acute postoperative pain: a review of current techniques and outcomes显示文摘 | ROGER L S ALAN N S W S JOEL K | 1999 | Pain1999，82，： | 1 |
| 13 | Dendritic cell expression of the Notch ligand jagged is not essential for Th2response induction in vivo显示文摘 | Alan G Salome L Emma S | 2008 | Eur J Immunol2008，38，： | 1 |
| 14 | NASA's approach to commercial cargo and crew transportation 显示文摘 | DENNIS S ALAN L GEORGE F etal | 2008 | Act Astronautica2008，63，： | 1 |
| 15 | Microwave pyrolysis,a novel process for recycling waste automotive engine oil显示文摘 | SU S L ALAN D R HOWARD A C | | 0，，35： | 1 |
| 16 | A QTL affecting daily feed intake maps to Chromosome2in pigs显示文摘 | Ross D H Chris S H Alan L A | 2005 | Mammalian Genome2005，16，6： | 1 |
| 17 | Changes in growth and photosynthetic capacity of rice with increased UV-B radia-tion显示文摘 | ALAN H TERMURA L H ZISKA E S A | 1991 | Physiol Planta1991，83，： | 1 |
| 18 | Molecular cloning of the cuticular collagen gene Bmcol-2 from Brugia malayi显示文摘 | Alan L Scott Pornwadee Yenbutr S Ward Eisinger Nithyakalyani Raghavan | 1995 | Molecular & Biochemical Parasitology1995，，1： | 1 |
| 19 | Electrical stimulation of repair of bone显示文摘 | Lavine L S Alan J Grodzinsky D | 1987 | J Bone Joint Surg1987，69，4： | 1 |
| 20 | Betalain,acid ascorbic,phenolic contents and antioxidant properties of purple,red,yellow and white cactus pears显示文摘 | SUMAYA M M T CRUZ J S MADRIGAL S E GARCíA P CARIO C J CRUZ C R VALADEZ V MARTINEZ C C L ALANíS G E | 2011 | International Journal of Molecular Sciences2011，12，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员