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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 3 | Spectral calibration of the EO-1 advanced land imager显示文摘 | Jeffrey G A Alexander P C | 1999 | SPIE1999，3750，： | 1 |
| 4 | Effect of stream channel size on the delivery of nitrogen to the Gulf of Mexico 显示文摘 | Alexander R B Smith R A Schwarz G E | 2000 | Nature2000，403，6771： | 1 |
| 5 | Isocyanoacetate derivatives: Synthesis, reactivity, and application 显示文摘 | Anton V G Alexander G Z Romano V A O | 2010 | Chem Rev2010，110，： | 1 |
| 6 | Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association 显示文摘 | Pearson T A Mensah G A Alexander R W | 2003 | Circulation2003，107，3： | 1 |
| 7 | MMCTP: a radiotherapy research environment for Monte Carlo and patientspecific treatment planning显示文摘 | Alexander A Deblois F Stroian G | 2007 | Phys Med Biol2007，52，13： | 1 |
| 8 | Estimation of nutrient sources and transport for New Zealand using the hybrid model SPARROW 显示文摘 | Elliott A Alexander R B Schwarz G E | 2005 | Journal of Hydrology (New Zealand)2005，44，1： | 1 |
| 9 | Mean-variance portfolio selection with ' at-risk 'constraints and discrete distributions 显示文摘 | Alexander G J Baptista A M Yan S | 2007 | Journal of Banking Finance2007，31，12： | 1 |
| 10 | A geochemical reconstruction of oil generation in the Barrow Sub-basin of Western Australia显示文摘 | Volkman J K Alexander R Kagi R I Noble R A Woodhouse G W | 1983 | Geochim Cosmochim Acta1983，47，12： | 1 |
| 11 | A comprehensive map of the porcine genome 显示文摘 | Rohrer G A Alexander L J Hu Z Smith T P L Keele JW Beattie C W | 1996 | Genome Res1996，6，： | 1 |
| 12 | Mutagenesis analysis of the nsp4 main proteinase reveals determinants of arterivirus replicase polyprotein autopro- cessing 显示文摘 | DANNY V A ERIC J S ALEXANDER E G | 2006 | J Virol2006，80，7： | 1 |
| 13 | Leveraging Knowledge, Learning, and Innovation in Forming Strategic Government-University-Industry(GUI) R&D Partnerships in the US, Germany, and France显示文摘 | Carayannis E G Alexander J Ioannidis A | 2000 | Technovation2000，20，： | 1 |
| 14 | A geometric analysis of diffusion tensor measurements of the human brain显示文摘 | Alexander A L Hasan K Kindlmann G | 2000 | Magn Reson Med2000，44，： | 1 |
| 15 | Nitrogen management in bioreactor landfills显示文摘 | Price Alexander G Barlaz Morton A Hater Gary R | 2003 | Waste Manag2003，23，： | 1 |
| 16 | Rapid indexing of the sunblotch disease of avocados using a complementary DNA probe to avocado sunblotch viroid显示文摘 | Palukaitis P A G Rakowski D Alexander | 1981 | Ann Appl Biol1981，98，： | 1 |
| 17 | Single-walled carbon nanotube-polymer composites: electrical, optical and structural investigation显示文摘 | Kymakis E Alexandou I Amaratunga G A J | 2002 | Synthetic Metals2002，127，1： | 1 |
| 18 | A site study of durability indexes for concrete in marine conditions显示文摘 | DU PREEZ A A ALEXANDER M G | 2004 | Materials and Structures2004，，37： | 1 |
| 19 | SufU is an essential iron-sulfur cluster scaffold protein in Bacillus subtilis显示文摘 | Alexander G Albrechtl Daili J A Netz Marcus Miethkel | 2010 | J Bacteriol2010，192，6： | 1 |
| 20 | Single walled carbon nanotube-polymer composites : Electrical, optical and structural investigation 显示文摘 | Kymakis E Alexandou I Amaratunga G A J | 2002 | Synth Met2002，127，： | 1 |
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