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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 3 | Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development显示文摘 | Hansen L A Alexander N Hogan M E Sundberg J P Dlugosz A Threadgill D W Magnuson T Yuspa S H | | 0，，06： | 1 |
| 4 | Global observed changes in daily climate extremes of temperature and precipitation显示文摘 | Alexander L Zhang X Peterson T | 2005 | Journal of Geophysical Research2005，111，05： | 1 |
| 5 | Formation of eutectic inter- metallic rosettes by entrapment of liquid droplets during cel- lular columnar growth显示文摘 | Alexander D T L Greer A L | 2004 | Acta Mater2004，52，： | 1 |
| 6 | Global observed changes in daily climate extremes of temperature and precipitation显示文摘 | ALEXANDER L V ZHANG X PETERSON T C | 2006 | J Geophys Res2006，111，3： | 1 |
| 7 | Global Observed Changes in Daily Climate Exiremes of Temperature and Precipitation显示文摘 | Alexander L V Zhang X Peterson T C | 2006 | Journal of Geo- physical Research Atmospheres2006，111，5： | 1 |
| 8 | A comprehensive map of the porcine genome 显示文摘 | Rohrer G A Alexander L J Hu Z Smith T P L Keele JW Beattie C W | 1996 | Genome Res1996，6，： | 1 |
| 9 | Roads and Their MajorEcological Effects显示文摘 | FORMAN R T T ALEXANDER L E | 1998 | Annual review of ecology and systematics1998，29，： | 1 |
| 10 | The elec- tro-deoxidation of dense titanium dioxide precursors in molten calcium chloride giving a new reaction pathway 显示文摘 | Alexander D T L Schwandt C Fray D J | 2011 | Electrochimica Acta2011，56，9： | 1 |
| 11 | Global observed changes in daily climate extremes of temperature and precipitation显示文摘 | Alexander L V Zhang X Peterson T C | | 0，，03： | 1 |
| 12 | Hepatitis C virus treatment in the real world: optimising treatment and access to therapies显示文摘 | Zoulim Fabien Liang T Jake Gerbes Alexander L Aghemo Alessio Deuffic-Burban Sylvie Dusheiko Geoffrey Fried Michael W Pol Stanislas Rockstroh Ju?rgen Kurt Terrault Norah A Wiktor Stefan | 2015 | Gut2015，，11： | 1 |
| 13 | Microstructural kinetics of phase transformations during electrochemical reduction of titanium dioxide in molten calcium chloride显示文摘 | ALEXANDER D T L SCHWANDT C FRAY D J | 2006 | Acta Materialia2006，54，11： | 1 |
| 14 | A disease of nursing pigs previously unreported in Ontario显示文摘 | ROE C K ALEXANDER T J L | 1958 | Can J Comp Med Vet Sci1958，22，9： | 1 |
| 15 | Solid-state intermetalle phase transformation in 3XXX aluminium alloys显示文摘 | ALEXANDER D T L GREER A L | 2002 | Acta Mate- rialia2002，50，10： | 1 |
| 16 | Immunization of pigs with live culture of Streptococcus suis type 2显示文摘 | HOLT M E ENRIGHT M R ALEXANDER T J L | 1988 | Res Vet Sci1988，45，3： | 1 |
| 17 | Arginine-supplemented diets improve survival in gut-derived sepsis and peritonitis by modulating bacterial clearance显示文摘 | Gianotti L Alexander JW Pyles T | 1993 | Ann Surg1993，217，6： | 1 |
| 18 | ,Meningitis in pigs caused by Streptococcus suis - a speculative review 显示文摘 | Chanter N Jones P W Alexander T J L | 1993 | Vet Microbiol1993，36，： | 1 |
| 19 | Utilizing the paracellular pathway: a novel approach for the delivery of oral insulin in diabetic rhesus macaques 显示文摘 | Watts T L Alexander T Hansen B | 2000 | J Invest Med2000，48，： | 1 |
| 20 | Leadership instability in hospitals:The influence of board-CEO relations and organizational growth and decline显示文摘 | Alexander J A Fennell M L Halpern M T | | 0，，01： | 1 |
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