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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Emulation of neutron irradiation effects with protons: validation of principle显示文摘 | G.S Was J.T Busby T Allen E.A Kenik A Jensson S.M Bruemmer J Gan A.D Edwards P.M Scott P.L Andreson | 2002 | Journal of Nuclear Materials2002，，2： | 2 |
| 3 | Fusion neutron and ion emission from deuterium and deuterated methane cluster plasmas显示文摘 | K W Madison P K Patel D Price A Edens, M Allen, T E Cowan, J Zweiback, T Ditmire | | 0，，： | 2 |
| 4 | The coexistence of multiple distribution systems for financial services: The case of property-liability insurance显示文摘 | Berger Allen N Cummins J David Weiss Mary A | 1997 | Journal of Business1997，10，： | 1 |
| 5 | Asymptotic profile of thesteady states for an SIS epidemic patch model显示文摘 | Allen L J S Bolker B M Lou Y Nevai A L | 2007 | SIAM J Appl Math2007，，67： | 1 |
| 6 | Commitment to Organizations and Occupations:Extension and Test of a Three-Component Conceptualization显示文摘 | Meyer J P Allen N J Smith C A | 1993 | Journal of Applied Psychology1993，78，： | 1 |
| 7 | Nonlinear shear instabilities of alongshore currents over barred beaches 显示文摘 | Slinn D N Allen J S Newberger P A | 1998 | Journal of Geophysical Research1998，103，18： | 1 |
| 8 | Neutron Diffraction Methods for the Study of Residual Stress Fields显示文摘 | ALLEN A J HUTCHINGS M T WINDSOR C G | 1985 | Adv Phys1985，34，4： | 1 |
| 9 | New production and photosynthetic rates within and outside a cyclonic mesoscale eddy in the North Pacific subtropical gyre显示文摘 | Allen C B Kanda J E A | 1996 | Deep Sea Research1996，43，： | 1 |
| 10 | Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C显示文摘 | Allen J D van Loevezijn A Lakhai J M | 2002 | Mol Cancer Ther2002，1，6： | 1 |
| 11 | ,Temporal and Spatial Variability in the Estrogenicity of a Municipal Wastewater Effluent显示文摘 | Hemming J M Allen H J Thuesen K A | 2004 | Ecotoxicology and Environmental Safety2004，57，： | 1 |
| 12 | Measurement of Flour Color in Color Space Parameters显示文摘 | Oliver J R Blakeney A B Allen H | 1992 | Cereal Chemistry1992，69，5： | 1 |
| 13 | Interaction of 14-3-3 with signaling proteins is mediated by the recogni- tion of phosphoserine 显示文摘 | Muslin A J Tanner J W Allen P M | 1996 | Cell1996，84，6： | 1 |
| 14 | Image method for efficiently simu- lating small-room acoustics 显示文摘 | Allen J B Berkley D A | 1979 | Journal of the Acoustical Society of America1979，65，4： | 1 |
| 15 | Measurement of flour color in color space parameters 显示文摘 | Oliver J R Blakeney A B Allen H M | 1992 | Cereal Chemistry1992，69，5： | 1 |
| 16 | The genome sequence of the psychrophilic archaeon, Methanococcoides burtonii: the role of genome evolution in cold adaptation显示文摘 | Allen M A Lauro F M Williams T J | 2009 | ISME J2009，3，9： | 1 |
| 17 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 18 | Venous thrombosis Associated with the placement of peripherally inserted central catheters显示文摘 | Allen A W Megargell J L Brown D B | 2000 | J Vase Interv Radio|2000，11，10： | 1 |
| 19 | Evolution of the void structure in plasma-sprayed YSZ deposits during heating显示文摘 | ILAVSKY J LONG G G ALLEN A J | 1999 | Materials Science and Engineering A1999，272，1： | 1 |
| 20 | Commitment to organizations and occupations:extension and test of a three-component con-ceptualization 显示文摘 | MEYER J P ALLEN N J SMITH C A | 1993 | Journal of applied psychology1993，，78： | 1 |
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