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| 1 | Characterization of monocarboxylate transporter activity in hepatocellular carcinoma显示文摘AIM: To assess the immunoexpression of hypoxiarelated markers in samples from cirrhosis and primary and metastatic hepatocellular carcinoma(HCC).METHODS: From a total of 5836 autopsies performed at the Pathology Department- University of Sao Paulo School of Medicine Hospital- from 2003 to 2009, 188 presented primary liver tumors. Immunohistochemical reactivity for monocarboxylate transporters(MCTs)-1, 2 and 4, CD147 and glucose transporter-1(GLUT1)was assessed in necropsies from 80 cases of HCC. Data were stored and analyzed using the IBM SPSS statistical software(version 19, IBM Company, Armonk, NY). All comparisons were examined for statistical significance using Pearson's χ2 test and Fisher's exact test(when n < 5). The threshold for significant P values was established as P < 0.05.RESULTS: Plasma membrane expression of MCT4 and overall expression of GLUT1 showed progressively higher expression from non-neoplastic to primary HCC and to metastases. In contrast, overall expression of MCT2 was progressively decreased from non-neoplastic to primary HCC and to metastases. MCT1(overall and plasma membrane expression), MCT2 and CD147 plasma membrane expression were associated with absence of cirrhosis, while plasma membrane expression of CD147 was also associated with absence of HBV infection. MCT2 overall expression was associated with lower liver weight, absence of metastasis and absence of abdominal dissemination. Additionally, MCT4 plasma membrane positivity was strongly associated with Ki-67 expression. CONCLUSION: MCT4 and GLUT1 appear to play a role in HCC progression, while MCT2 is lost during progression and associated with better prognosis. | Venncio AF Alves Céline Pinheiro Filipa Morais-Santos Aloisio Felipe-Silva Adhemar Longatto-Filho Fátima Baltazar | 2014 | World Journal of Gastroenterology2014，20，33： | 11 |
| 2 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 3 | NEW TOXOPLASMA GONDII GENOTYPES ISOLATED FROM FREE-RANGE CHICKENS FROM THE FERNANDO DE NORONHA, BRAZIL: UNEXPECTED FINDINGS显示文摘 | Dubey J P Rajendran C Costa D G C Ferreira L R Kwok O C H Qu D Su C Marvulo M F V Alves L C Mota R A Silva J C R | 2010 | The Journal of Parasitology2010，，4： | 2 |
| 4 | Positive solu- tions for a quasilinear elliptic equations of Kirchhoff type显示文摘 | Alves C O Correa F J S A Ma T F | 2005 | Comput Math Appl2005，4，： | 1 |
| 5 | RBS lattice site location and damage recovery studies in GaN 显示文摘 | Alves E DaSilva M F Soares J C | 1999 | MRS Internet J Nitride Semiconductor Res1999，4，1： | 1 |
| 6 | Unique (Y; 13 ) translocation in a male with oligozoospermia: eytogenetie and molecular studies显示文摘 | Alves C Carvalho F Cremades N | 2002 | Eur J Hum Genet2002，10，： | 1 |
| 7 | New multi-phase sys- tems based on tin compounds active for vegetable oil transesteri- fication reaction显示文摘 | ABREU F R ALVES M B MACEDO C C | 2005 | Journal of Molecular A Chemical2005，227，： | 1 |
| 8 | Quantitative analyses of kidney injury molecule -1messenger RNA in kidney transplant recipients with graft dysfunc-tion显示文摘 | Nogare A L Joelsons G Pedroso J A Veronese F J Gonalves L F Manfro R C | 2010 | Transplant Proc2010，42，： | 1 |
| 9 | New multi-phase catalytic systems based on tin compounds active for vegetable oil transesterification reaction 显示文摘 | Abreu F R Melquizedeque B Alves Caio C S | 2005 | Journal of Molecular catalysis A : Chenmical2005，227，： | 1 |
| 10 | End-to-end joining of tubes by plastic instability 显示文摘 | Alves L M Silva C M A Martins P A F | 2014 | Journal of Materials Processing Technology2014，214，9： | 1 |
| 11 | Antigenotoxicity and antimutagenicity of lycopene in HepG2 cell line evaluated by the comet assay and mieronueleus test 显示文摘 | Scolastici C Alves de Lima Barbisan F | 2008 | Toxicology in Vitro2008，，22： | 1 |
| 12 | Isolation and initial characterization of a bacterial consortium able to mineralize fluorobenzene显示文摘 | Carvalho M F Alves C C T Ferreira M I M | 2002 | Applied and Environmental Microbiology2002，68，1： | 1 |
| 13 | Positive Solutions for a Quasilinear Elliptic Equation of Kirchhoff Type 显示文摘 | ALVES C O CORREA F J S A MAT F | 2005 | Comput Math Appl2005，49，： | 1 |
| 14 | Degradation profiles of cast films of polyurethane and poly (urethane-urea) aqueous dispersions based on hydroxy-terminated polybutadiene and different diisocyanates 显示文摘 | Coutinho F M W Delpeeh M C Alves T L | 2003 | Polym Degrad Stab2003，81，1： | 1 |
| 15 | Influence of fabrication process on the final properties of natural-rubber latex tubes for vascular prosthesis显示文摘 | NEVES-JUNIOR W F P FERREIRA M ALVES M C O | 2006 | Brazilian Journal of Physics2006，36，2： | 1 |
| 16 | Degradation profiles of east films of polyurethane and poly(urethane-urea) aqueous dispersions based on hydroxyterminated polybutadiene and different diisocyanates显示文摘 | Coutinho F M B Delpech M C Alves T L | 2003 | Polymer Degradation and Stability2003，81，1： | 1 |
| 17 | Influence of weathering and gamma irradiation on the me- chanical and ballistic behavior of UHMWPE composite ar- mor显示文摘 | Dos Santos Alves A L Nascimento L F C Suarez J C M | 2005 | Polym Test2005，24，1： | 1 |
| 18 | The influence of the dispersion technique on the characteristics of the W-Cu powders and on the sintering behavior显示文摘 | da ALVES F C da PEREIRA A G S GOMES U U | 2003 | Powder Technology2003，134，12： | 1 |
| 19 | Forming of thin-walled hollow spheres using sacrificial polymer mandrels显示文摘 | Alves L M Pardal T C D Martins P A F | 2009 | International Journal of Machine Tools and Manufacture2009，49，6： | 1 |
| 20 | Influence of weathering andgamma irradiation on the mechanical and ballistic be-havior of UHMWPE composite armor显示文摘 | DOS SANTOS ALVES A L CASSIANO NASCIMEN-TO L F SUAREZ J C M | 2005 | Polymer Test-ing2005，24，1： | 1 |
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