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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Assessment of interobserver variation in Garden classification and management of fresh intracapsular femoral neck fracture in adults显示文摘ObjectiveTo 在如果侧面的看法的增加改变整形外科的外科医生被要求仅仅在 AP 看法上分类 35 大腿骨的颈破裂并且建议管理的分类和管理 plan.MethodsTen ,骨折和管理计划基于 anteroposterior ( AP )看并且也估计的新鲜的大腿骨的颈的花园分类上估计 interobserver 协议计划。当时,一样的电影是在 10 天以后与他们的侧面的看法一起重新显示出。结果与到在二个组之间的分类和管理计划的尊重相比。Interobserver 同意用 Fleiss’ 被计算kappa.ResultsThere 仅仅仅仅在 AP 看法上的花园分类上是一个公平 interobserver 协议(kappa 价值 0.39 ) 它改善了在增加一个侧面的看法以后节制同意(kappa 价值 0.52 ) 。当仅仅在 AP 上的管理计划上的 interobserver 协议有细微改进时,仅仅看(kappa 价值 0.50 ) 并且 AP 与侧面的看法(kappa 价值 0.52 ) 结合了。侧面的看法的补充在 15.42% 盒子中改变了分类并且在 23.14% cases.ConclusionWe 改变了管理计划断定当它毫无疑问在计划大腿骨的颈骨折的治疗有一个角色,那个侧面的看法应该与怀疑的大腿骨的颈骨折在所有病人上习惯性地被获得。 | Amit Aggarwal Mahipal Singh Aditya N Aggarwal Shuchi Bhatt | 2014 | Chinese Journal of Traumatology2014，17，2： | 13 |
| 3 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 4 | Endoscopic features of sessile serrated adenomas: validation by international experts using high-resolution white-light endoscopy and narrow-band imaging显示文摘 | Yark Hazewinkel Maria López-Cerón James E. East Amit Rastogi Maria Pellisé Takeshi Nakajima Susanne van Eeden Kristien M.A.J. Tytgat Paul Fockens Evelien Dekker | 2013 | Gastrointestinal Endoscopy2013，，6： | 2 |
| 5 | Red meat and poultry intake, polymorphisms in the nueleotide excision repair and mismatch repair pathways and colorectal cancer risk显示文摘 | Amit D Joshi Roma'n Corral | 2009 | Carcinogenesis2009，30，3： | 1 |
| 6 | Bitumen surface energy characterization using a contact angle approach 显示文摘 | HEFER A W AMIT B DALLAS N | 2006 | Journal of Materials in Civil Engineering2006，18，6： | 1 |
| 7 | Mast cell stabilization,lipoxygenase inhibition,hyaluronidase inhibition,antihistaminic and antispasmodic activities of Aller-7,a novel botanical formulation for allergic rhinitis显示文摘 | Amit A Saxena VS Pratibha N | | 0，，： | 1 |
| 8 | Chronic fatigue syndrome: characteristics and possible causes for its pathogenesis显示文摘 | Bassi N Amital D Amital H | 2008 | Isr Med Assoc J2008，10，1： | 1 |
| 9 | Diagnostic value of power Doppler measurements in the endometrium of women with postmenopausal bleeding显示文摘 | Amit A Weiner Z Ganem N | 2000 | Gynecol Oncol2000，77，2： | 1 |
| 10 | Mast cell stabilization,lipoxygenase inhibition,hyaluronidase inhibition,antihistaminic and antispasmodic activities of Aller-7,a novel botanical formulation for allergic rhinitis显示文摘 | AMIT A SAXENA V S PRATIBHA N | 2003 | Drugs Exp Clin Res2003，29，： | 1 |
| 11 | Acute toxicity assessment of choline by inhalation, intraperitoneal and oral routes in Balb/c mice显示文摘 | AMIT K M NAVEEN A SHAILENDRA N G | 2009 | Regulatory Toxicology and Pharmacology2009，54，3： | 1 |
| 12 | Utilization potentials of industrial mining rejects and tailings as building materials 显示文摘 | Rais Amits Raos D B N | 2005 | Manage Environ Qual: Int J2005，16，6： | 1 |
| 13 | Chronic fatigue syndrome: characteristics and possible causes for its pathogenesis显示文摘 | Bassi N Amital D Amital H | 2008 | Isr MedAssoc J2008，10，1： | 1 |
| 14 | Plasmid DNA loaded chitosan nanoparticles for nasal mucosal immunization against hepatitis B显示文摘 | Kapil K Amit K G Prem N G | 2008 | Inter J Pharm2008，354，12： | 1 |
| 15 | The overlapping roles of manganese and Cu/Zn SOD in oxidative stress protection显示文摘 | AMIT R R LARAN T J AMORNRAT N | 2009 | Free Radical Biology &Medicine2009，46，： | 1 |
| 16 | The diaghostic value of power Doppler measurements in the endometrium of women with postmenopausal bleeding显示文摘 | Amit A Weiner Z Ganem N | 2000 | Gynecol Oncol2000，77，： | 1 |
| 17 | Growth hormone-stimulated in- sulin-like growth factor (IGF) 1 and IGF-binding protein-3 in liver cirrhosis显示文摘 | Assy N Hochberg Z Amit T | 1997 | J Hepatol1997，27，5： | 1 |
| 18 | Prediction of the Removal Efficiency of a Novel Two-stage Hybrid Scrubber for Flue Gas Desulfurization显示文摘 | Amite B Manindra N B | 2006 | Chemical Engineering and Technology2006，29，1： | 1 |
| 19 | Snail and slug are major determinants of ovarian cancer invasiveness at the transcription level显示文摘 | KURREY N AMIT K BAPAT S | 2005 | Gynecol Onco2005，97，1： | 1 |
| 20 | Snail and Slug are major determinants of ovarian cancer invasiveness at the tr- ranscription level显示文摘 | Kurrey N K Amit K Bapat S A | 2005 | Gynecologic Oncol2005，97，： | 1 |
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