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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | N-terminal pro-brain natriuretic pep- tide predicts outcome after hospital discharge in heart failure patients 显示文摘 | Paulo B Ana A Joana P | 2004 | Circulation2004，10，110： | 1 |
| 3 | Study of solid - liquid extraction kinetics of total polyphenols from grape seeds显示文摘 | Ana B K Mirela P Srec'ko T | 2007 | Journal of Food Engineering2007，，81： | 1 |
| 4 | Protoplast production from napier grass and pearl millet triploid hybrids 显示文摘 | Ana L O T Lisete C D Jos6 E B P P | 2010 | Scientific Electronic Library Online2010，34，5： | 1 |
| 5 | Three-year investigation of the natural airbome bacterial flora at four localities in Sweden显示文摘 | Bovallius A B B R Roffey P Anas | | 0，，： | 1 |
| 6 | Removal of pollutants from indoor air using zeolite membranes显示文摘 | Sonia A Ana C P Marya P B | 2004 | Journal of Membrane Science2004，240，： | 1 |
| 7 | Structural and optical properties of polypropylene-montmorillonite nanocomposites显示文摘 | Lucilene B P Ana T M Thiago R G | 2007 | Materials Science and Engineering A2007，447，12： | 1 |
| 8 | Identification of immunodominant antigens of Mycobacterium boris by expression library immunization显示文摘 | Paulina K B Abel G O Ana M P | 2011 | The Veterinary Jour- nal2011，190，： | 1 |
| 9 | A spare parts model with cold-standby redundancy on system level 显示文摘 | Karin S S D Nicole P E Ana I B | 2011 | Computers : Operations Research2011，38，7： | 1 |
| 10 | Highly conductive ambient-temperature melten salts显示文摘 | Pierre B T Ana P D Nicho L P R | 1996 | Inorg Chem1996，35，10： | 1 |
| 11 | Polymorphisms in exons 6 and 7 of the ABO locus and their association with venous thrombosis in young Brazilian patients显示文摘 | Sabrina G Paiva Adriano P Sabino Maria G Carvalho Daniel D Ribeiro Karina B Gomes Mariana S Santos Marina S Oliveira Geralda G Lages Luci MS Dusse Ana Paula Fernandes | 2009 | Blood Coagulation & Fibrinolysis2009，，2： | 1 |
| 12 | Arabidopsis and tobacco plants ectopically expressing the soybean antiquitin-like ALDH7 gene display enhanced tolerance to drought,salinity,and oxidative stress显示文摘 | Simone M R Maxuel O A Ana P S G Fabio M D Maria C B P Elizabeth P B F | | 0，，： | 1 |
| 13 | Localized precipitation forecasts from a numerical weather prediction model using artificial neural net: works显示文摘 | Robert J K Ana P B | 1998 | Weather and Forecasting1998，13，4： | 1 |
| 14 | The effect of thermal treatment on the properties of sol-gel copper-silica eatalysts显示文摘 | Edesia M B D S Ana P G Nelcy D S | 2001 | Appl Surf Sci2001，183，34： | 1 |
| 15 | Effects of soybean Kunitz trypsin inhibitor on the cotton boll weevil (Anthonomus grandis)显示文摘 | FRANCOA O L DIASB S C MAGALHA_ESD C P MONTEIROA ANA C S JR C B MELOE F R OLIVEIRA-NETOA O B MONNERATA R G GROSSI-DE-SA M F | 2004 | Phytochernistry2004，65，1： | 1 |
| 16 | Eu3 + and Tm3 + doped yttrium oxide thin films for optical applications 显示文摘 | Moll Y O P Huignard A Autic-Fidancev E Aschehoug P Vi- ana B Millon E | 2000 | Journal of Luminescence2000，8789，： | 1 |
| 17 | The effect of thermal treatment on the properties of sol-gel copper-silica catalysts 显示文摘 | EDESIA M B D S ANA P G NELCY D S | 2001 | Appl Surf Sci2001，183，： | 1 |
| 18 | Last trends in pesticide residue determination by liquid chromatography-mass spectrometry显示文摘 | Ana M Cristina B Yolanda P | 2014 | Trends in Environmental Analytical Chemistry2014，2，： | 1 |
| 19 | Organoclays:Properties,preparation and applications显示文摘 | Lucilene B P Ana R M Francisco R | 2008 | Applied Clay Science2008，42，12： | 1 |
| 20 | Influence of insoluble dietary cellulose on digestive enzyme activity, feed digestibility and survival in the red claw crayfish, Cherax quadricarinatus (von Martens)显示文摘 | Ana P Neil A R Peter B M | 2006 | Aquac Res2006，37，： | 1 |
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