|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients显示文摘AIM: To investigate the effect of omega-3 fatty acid parenteral supplementation postoperatively on clinical outcomes and immunomodulation in colorectal cancer patients. METHODS: Forty-two patients undergoing radical colorectal cancer resection with an indication for total parenteral nutrition postoperatively were enrolled in this prospective, double-blind, randomized, controlled study. Patients received total parenteral nutrition supplemented with either soybean oil (LCT; Intralipid, Fresenius-Kabi, SO group, n = 21) or a combination of omega-3 fish oil and soybean oil (LCT:fish oil = 5:1, fish oil; Omegaven, Fresenius-Kabi, FO group, n = 21), up to a total of 1.2 g lipid/kg per day for 7 d postoperatively. A same volume calorie and nitrogen was administrated. Routine blood test, biochemistry, systemic levels of IL-6 and TNF-α, percentage of CD3+, CD4+, and CD8+ lymphocytes were evaluated preoperatively and on postoperative d 1 and 8. Patient outcome was evaluated considering mortality during the hospital stay, length of postoperative hospital stay, and occurrence of infectious complications. RESULTS: Both lipid regimens were well tolerated. No differences between the two groups were noticed in demographics, baseline blood test, biochemistry, serum levels of IL-6 and TNF-α, percentage of CD4+, CD8+ lymphocytes, and ratios of CD4+/CD8+. Compared with those on postoperative d 1, serum IL-6 levels onpostoperative d 8 were significantly depressed in the FO group than in the reference group (-44.43 ± 30.53 vs -8.39 ± 69.08, P = 0.039). Simultaneously, the ratios of CD4+/CD8+ were significantly increased in the FO group (0.92 ± 0.62 vs 0.25 ± 1.22, P = 0.035). In addition, depression of serum TNF-α levels (-0.82 ± 2.71 vs 0.27 ± 1.67, P = 0.125) and elevation of CD3+ and CD4+ lymphocyte percentage (12.85 ± 11.61 vs 3.84 ± 19.62, P = 0.081, 17.80 ± 10.86 vs 9.66 ± 17.55, P = 0.084, respectively) were higher in the FO group than in the reference group. Patients in the FO group trended to need a shorter postoperative hospital stay (17.45 ± 4.80 d vs 19.62 ± 5.59 d, P = 0.19). No statistically significant difference was found when stratified to mortality and occurrence of infectious complications. CONCLUSION: Postoperative supplementation of omega-3 fatty acids may have a favorable effect on the outcomes in colorectal cancer patients undergoing radical resection by lowering the magnitude of inflammatory responses and modulating the immune response. | Bin Liang, Shan Wang, Ying-Jiang Ye, Xiao-Dong Yang, You-Li Wang, Jun Qu, Qi-Wei Xie, Mu-Jun Yin, Division of Surgical Oncology and Division of Gastroenterological Surgery, Peking University People’s Hospital, Beijing 100044, China Author contributions: Liang B and Wang S contributed equally to this work Liang B and Wang S designed the research Liang B, Ye YJ, Yang XD, Wang YL, Qu J, Xie QW, Yin MJ performed the research and collected the data Wang S and Ye YJ supervised the research Liang B and Ye YJ analyzed the data Liang B wrote the paper and revised the manuscript. | 2008 | World Journal of Gastroenterology2008，14，15： | 31 |
| 2 | Structure and function of aggrecan显示文摘Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties. It is also crucial in chondroskeletal morphogenesis during development. Aggrecan is a multimodular molecule expressed by chondrocytes. Its core protein is composed of three globular domains (G1, G2, and G3) and a large extended region (CS) between G2 and G3 for glycosaminoglycan chain attachment. G1 comprises the amino terminus of the core protein. This domain has the same structural motif as link protein. Functionally, the G1 domain interacts with hyaluronan acid and link protein, forming stable ternary complexes in the extracellular matrix. G2 is homologous to the tandem repeats of G1 and of link protein and is involved in product processing. G3 makes up the carboxyl terminus of the core protein. It enhances glycosaminoglycan modification and product secretion. Aggrecan plays an important role in mediating chondrocyte-chondrocyte and chondrocyte-matrix interactions through its ability to bind hyaluronan. | CHRIS KIANI, LIWEN CHEN, YAO JIONG WU, ALBERT J YEE, BURTON B YANG, Sunnybrook and Women’s College Health Sciences Centre and Department of Laboratory Medicine and Patobiology, 2 Department of Surgeny, Faculty of Medicine, University of Toronto, Canada | 2002 | Cell Research2002，12，1： | 27 |
| 3 | HIGH-ENERGY IONS PRODUCED IN EXPLOSIONS OF SUPERHEATED ATOMIC CLUSTERS显示文摘 | T Ditmire J W G Tisch E Springate M B Mason N Hay R A Smith J Marangos and M H R Hutchinson | | 0，，： | 4 |
| 4 | Risk Assessment in Construction Schedules显示文摘 | Mulholland B and Christian J | 1999 | Journal of Construction Engineering and Management1999，125，1： | 2 |
| 5 | Safety analysis, synthesis using fuzzy sets and evidential reasoning显示文摘 | WANG J YANG J B and SEN P | 1995 | Reliability engineering and system safety1995，47，： | 2 |
| 6 | Genetic influences on beef longissimus palatability in Charolais-and Limousin-sired steers and heifers显示文摘 | Wulf D M Tatum J D Green R D Morgan J B Golden B L and Smith G C | 1996 | J Anim Sci1996，74，： | 2 |
| 7 | Additional conjugation methods and immunogenicity of Bacillus anthracis poly-gamma-D-glutamic acid-protein conjugates 显示文摘 | Kubler-Kielb J Liu T Y Mocca C Majadly F Robbins J B and Schneerson R | 2006 | Infection and Immunity2006，74，8： | 1 |
| 8 | A global geometric framework for nonlinear dimensionality reduction显示文摘 | Tenenbanm J B De Silva V and Langford J C | 2000 | Science2000，290，5500： | 1 |
| 9 | Indirect enzyme-linked immunosorbent assay for the mycotoxin zearalenone显示文摘 | Liu M T Ram B P Hart L P and Pestka J J | 1985 | Appl Environ Microbiol1985，50，2： | 1 |
| 10 | Purification early pregnancy factor expressed in Sf9 insect cells and in Escherichia coli 显示文摘 | Somodevilla-Torres M J Morton H and characterisation of functional Zhang B | 2003 | Protein Expr Purif2003，32，2： | 1 |
| 11 | Leadership development in UK companies at the beginning of the twenty-first century: Lessons for the NHS? 显示文摘 | Alimo-Metcalfe B and Lawler J | 2001 | Journal of Management in Medicine2001，15，5： | 1 |
| 12 | Pore water pressure changes during soils liquefaction显示文摘 | Seed H B Martin P P and Lysmer J | 1976 | Journal of Geotechnical Engineering Division ASCE1976，102，4： | 1 |
| 13 | Chem显示文摘 | Yu M F Yakobson B I and Ruoff R S Phys J | 2000 | B2000，104，： | 1 |
| 14 | Physical pictures of transport in heterogeneous media:Advection-dispersion,random-walk and fractional derivative formulations显示文摘 | Berkowitz B Klafter J and Metzler R | 2002 | Water Resources Research2002，38，10： | 1 |
| 15 | Exploring the phenomenon of customers, desired value change in a business-to-business context显示文摘 | Flint D J Woodruff R B and Gardial S F | 2002 | Journal of Marketing2002，66，10： | 1 |
| 16 | Modified Hodge and EDTA-disk synergy tests to screen metallo-beta-lactamase-producing strains of Pseudomonas and Acinetobacter species显示文摘 | Lee K Y·Chong H·B·Shin Y·A·Kim D·Yong and J·H·Yum | 2001 | Clin Microbiol Infect2001，7，： | 1 |
| 17 | Theoretical stress-strain model for confined concrete 显示文摘 | Mander J B Pfiestley M J N and Park R | 1988 | Journal of Structural Engineering ASCE1988，114，8： | 1 |
| 18 | Determination of tectonic setting of sandstone-mudstone suites using SiO2 content and K2O/Na2O ratio显示文摘 | ROSER B P and KORSCH R J | 1986 | Journal of Geology1986，94，： | 1 |
| 19 | Tumor necrosis factor α-induced interleukin-32 is positively regulated via the Syk/protein kinase Cδ/JNK pathway in rheumatoid synovial fibroblasts显示文摘 | Mun S H Kim J W Nah S S Ko N Y Lee J H Kim J D Kim do K Kim H S Choi J D Kim S H Lee C K Park S H Kim B K Kim H S Kim Y M and Choi W S | | 0，，03： | 1 |
| 20 | Affect and creativity at work显示文摘 | Amabile T M Barsade S G Mueller J S and Staw B M | 2005 | Administrative Science Quarter- ly2005，50，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员