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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Proteomic anal- ysis of the cambial region in juvenile Eucalyptus grandis at three ages 显示文摘 | Celedon P A F de Andrade A Meireles K G X | 2007 | Proteomics2007，7，13： | 1 |
| 3 | Thermo-rheological behavior of model protein-polysaccharide mixtures 显示文摘 | Andrade R J Azevedo A G Musampa R M | 2010 | Rheologica Acta2010，49，4： | 1 |
| 4 | Comparison of six-minute walk test in children with moderate/ severe asthma with reference values for healthy children显示文摘 | ANDRADE L B SILV A R G SALGADO T L B | 2014 | Jomal de Pediatria2014，90，3： | 1 |
| 5 | Halbach Array Supercon- ducting Magnetic Bearing for a Flywheel Energy Storage System 显示文摘 | Sotelo G G Ferreira A C Andrade R J | 2005 | IEEE Transactions on Applied Superconductivity2005，6，15： | 1 |
| 6 | Activation of the PI3K/Akt pathway early during vaccinia and cowpox virus infections is required for both host survival and viral replication 显示文摘 | SOARES J A LEITE F G ANDRADE L G | 2009 | J Virol2009，83，13： | 1 |
| 7 | Unrepeated WDM transmission systems based on advanced first-order and higher order raman-copumping technology 显示文摘 | FARALLI S BOLOGNINI G ANDRADE M A | 2007 | Journal of Lightwave Technology2007，25，11： | 1 |
| 8 | Halbach array superconducting magnetic bearing for a flywheel energy storage system 显示文摘 | Sotelo G G Ferreira A C de Andrade R | 2005 | IEEE Transactions on Applied Su- perconductivity2005，15，2： | 1 |
| 9 | Synthesis of aNiFe204 catalyst for the preferential oxidation of carbon monoxide (PROX)显示文摘 | SANTOS P T A COSTA A C F M KIMINAMI R H G A ANDRADE H M C LIRA H L GAMA L | 2009 | Journal of Alloy and Compounds2009，483，12： | 1 |
| 10 | Friedel-Crafts acylaiton of anisole with acetic anhydride over silica-supported hetempolyphostungstic acid (HPW/SiO2 )显示文摘 | CARDOSO L A M ALVES W It GONZAGA A R E AGUIAR L M G ANDRADE H M C | 2004 | J Mol Catal A2004，209，12： | 1 |
| 11 | Varietal identification of coffee seeds by RAPD technique显示文摘 | Croehemore M L Nunes L M Andrade G A | 2004 | Brazilian Archives of Biology and Technology2004，47，1： | 1 |
| 12 | Screening for in vivo(anti) estrogenic and ( anti ) androgenic activities of technical and formulated dehamethrin 显示文摘 | ANDRADE A J ARAUJO S SANTANA G M | 2002 | Regul Toxicol Pharmacol2002，35，3： | 1 |
| 13 | Cream cheese as a symbiotic food carrier using B ifidobacterium animalis B b‐12 and L actobacillus acidophilus L a‐5 and inulin显示文摘 | Larissa L Alves Neila S P S Richards Paula Mattanna Diego F Andrade Adriano P S Rezer Liana I G Milani Adriano G Cruz José A F Faria | 2012 | Int J Dairy Technol2012，，1： | 1 |
| 14 | Experimental and mechanical model for predicting the behaviour of minor axis beam-to-column semi-rigid joints 显示文摘 | de Lima L R O de Andrade S A L da S Vellasco P C G | 2002 | International Journal of Mechanical Science2002，44，6： | 1 |
| 15 | Friending the Taxman:On the Use of Social Networking Services for Government eID in Europe显示文摘 | Martin A K Nuno N Andrade G | 2013 | Telecommunications Policy2013，37，： | 1 |
| 16 | Aroma volatile constituents of Brazilian varieties of mango fruit显示文摘 | Andrade E H A Maia J G S Zoghbi M D G B | 2000 | Journal of Food Composition and Analysis2000，13，1： | 1 |
| 17 | Hemorrhagic ascites associated with endometriosis:a case report显示文摘 | Dias C C Andrade J M Ferriani R A Villanova M G Meirelles R S | 2000 | J Reprod Med2000，45，： | 1 |
| 18 | Aroma volatile constituents of Brazilian varieties of mango fruit 显示文摘 | ANDRADE E H A MAIA J G S ZOGHBI M G B | 2000 | Journal of Food Composition and Analysis2000，13，： | 1 |
| 19 | Small-angle X-ray scattering and FTIR characterization of nanostructured poly (vinyl alcohol)/ silicate hybrids for immunoassay applications 显示文摘 | ANDRADE G I STANCIOLI E F B MANSUR A A P VASCONCELOS W L MANSUR H S | 2008 | Journal of Material Science2008，43，： | 1 |
| 20 | 显示文摘 | Andrade A Z Rodrigues J K Dib L A Rom?o G S Ferriani R A Jord?o Junior A A | 2010 | Rev Bras Ginecol Obstet2010，32，： | 1 |
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